Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity

Ahmed A Elzatahry1,4, Abdullah M Al-Enizi1, Elsayed Ahmed Elsayed2,5, Rachel R Butorac3, Salem S Al-Deyab1, Mohammad AM Wadaan2, Alan H Cowley31Petrochemical Research Chair, Department of Chemistry, 2Chair of Advanced Proteomics &amp; Cytomics Research, Faculty of Science, King Saud Universi...

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Autores principales:	Elzatahry AA, Al-Enizi AM, Elsayed EA, Butorac RR, Al-Deyab SS, Wadaan MAM, Cowley AH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/36269095eccf42eabebb4c95b77e1a80
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spelling	oai:doaj.org-article:36269095eccf42eabebb4c95b77e1a802021-12-02T05:09:41ZNanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity1176-91141178-2013https://doaj.org/article/36269095eccf42eabebb4c95b77e1a802012-06-01T00:00:00Zhttp://www.dovepress.com/nanofiber-composites-containing-n-heterocyclic-carbene-complexes-with--a10059https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ahmed A Elzatahry1,4, Abdullah M Al-Enizi1, Elsayed Ahmed Elsayed2,5, Rachel R Butorac3, Salem S Al-Deyab1, Mohammad AM Wadaan2, Alan H Cowley31Petrochemical Research Chair, Department of Chemistry, 2Chair of Advanced Proteomics &amp; Cytomics Research, Faculty of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX, USA; 4Institute of Advanced Technology and New Materials, City for Scientific Research and Technology Applications, New Borg Alrab, Alexandria, Egypt; 5Natural &amp; Microbial Products Department, National Research Centre, Dokki, Cairo, EgyptAbstract: This report concerns nanofiber composites that incorporate N-heterocyclic carbenes and the use of such composites for testing antimicrobial and antifungal activities. The nanofiber composites were produced by electrospinning mixtures of the gold chloride or gold acetate complexes of a bis(imino)acenaphthene (BIAN)-supported NHC with aqueous solutions of polyvinyl alcohol (PVA). The products were characterized by scanning-electron microscopy, which revealed that nanofibers in the range of 250&ndash;300 nm had been produced. The biological activities of the nanofiber composites were tested against two Gram-positive bacteria, six Gram-negative bacteria, and two fungal strains. No activity was evident against the fungal strains. However, the gold chloride complex was found to be active against all the Gram-positive pathogens and one of the Gram-negative pathogens. It was also found that the activity of the produced nanofibers was localized and that no release of the bioactive compound from the nanofibers was evident. The demonstrated antimicrobial activities of these novel nanofiber composites render them potentially useful as wound dressings.Keywords: nanofiber, electrospinning, N-Heterocyclic carbene, biopolymer, antimicrobialElzatahry AAAl-Enizi AMElsayed EAButorac RRAl-Deyab SSWadaan MAMCowley AHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2829-2832 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Elzatahry AA Al-Enizi AM Elsayed EA Butorac RR Al-Deyab SS Wadaan MAM Cowley AH Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity
description	Ahmed A Elzatahry1,4, Abdullah M Al-Enizi1, Elsayed Ahmed Elsayed2,5, Rachel R Butorac3, Salem S Al-Deyab1, Mohammad AM Wadaan2, Alan H Cowley31Petrochemical Research Chair, Department of Chemistry, 2Chair of Advanced Proteomics &amp; Cytomics Research, Faculty of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX, USA; 4Institute of Advanced Technology and New Materials, City for Scientific Research and Technology Applications, New Borg Alrab, Alexandria, Egypt; 5Natural &amp; Microbial Products Department, National Research Centre, Dokki, Cairo, EgyptAbstract: This report concerns nanofiber composites that incorporate N-heterocyclic carbenes and the use of such composites for testing antimicrobial and antifungal activities. The nanofiber composites were produced by electrospinning mixtures of the gold chloride or gold acetate complexes of a bis(imino)acenaphthene (BIAN)-supported NHC with aqueous solutions of polyvinyl alcohol (PVA). The products were characterized by scanning-electron microscopy, which revealed that nanofibers in the range of 250&ndash;300 nm had been produced. The biological activities of the nanofiber composites were tested against two Gram-positive bacteria, six Gram-negative bacteria, and two fungal strains. No activity was evident against the fungal strains. However, the gold chloride complex was found to be active against all the Gram-positive pathogens and one of the Gram-negative pathogens. It was also found that the activity of the produced nanofibers was localized and that no release of the bioactive compound from the nanofibers was evident. The demonstrated antimicrobial activities of these novel nanofiber composites render them potentially useful as wound dressings.Keywords: nanofiber, electrospinning, N-Heterocyclic carbene, biopolymer, antimicrobial
format	article
author	Elzatahry AA Al-Enizi AM Elsayed EA Butorac RR Al-Deyab SS Wadaan MAM Cowley AH
author_facet	Elzatahry AA Al-Enizi AM Elsayed EA Butorac RR Al-Deyab SS Wadaan MAM Cowley AH
author_sort	Elzatahry AA
title	Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity
title_short	Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity
title_full	Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity
title_fullStr	Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity
title_full_unstemmed	Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity
title_sort	nanofiber composites containing n-heterocyclic carbene complexes with antimicrobial activity
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/36269095eccf42eabebb4c95b77e1a80
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Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity

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