Age-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 2020

The aim of this study was to investigate the serotype-associated fatality rate in cases of invasive pneumococcal disease (IPD) in the Spanish region of Madrid between 2007 and 2020. Serotyping was performed by Pneumotest Latex and the Quellung reaction using commercial antisera. Case-fatality rate w...

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Autores principales:	Sara De Miguel, Pello Latasa, José Yuste, Luis García, María Ordobás, Belén Ramos, Marta Pérez, Maira Alejandra Ortiz, Juan Carlos Sanz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Streptococcus pneumoniae</i> invasive pneumococcal disease serotype vaccine fatality Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3629254e10c443f8ba30ed2868d7ddb0
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id	oai:doaj.org-article:3629254e10c443f8ba30ed2868d7ddb0
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spelling	oai:doaj.org-article:3629254e10c443f8ba30ed2868d7ddb02021-11-25T18:24:52ZAge-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 202010.3390/microorganisms91122862076-2607https://doaj.org/article/3629254e10c443f8ba30ed2868d7ddb02021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2286https://doaj.org/toc/2076-2607The aim of this study was to investigate the serotype-associated fatality rate in cases of invasive pneumococcal disease (IPD) in the Spanish region of Madrid between 2007 and 2020. Serotyping was performed by Pneumotest Latex and the Quellung reaction using commercial antisera. Case-fatality rate was estimated as the ratio between the number of deaths at hospital discharge and the number of cases attributable to each serotype. To evaluate the association measures, the odds ratios with a 95% confidence interval were calculated. Twenty five pneumococcal serotypes were associated to mortality and comprised 87.8% of the total number of isolates characterized. Serotypes 8, 3, 19A, 1, 7F, 22F, 12F, and 11A were the most prevalent (≥3% each). Serotypes 31, 11A, and 19F were significantly associated to high case-fatality rates (>20% each). The lower significantly associated case-fatality rate (<10% each) was found in serotypes 5, 1, 12B, 7F, 12F, 8, 33, and 10A. The serotypes with higher mortality levels (≥0.04 per 100,000 population) were 11A (fatality 24.0%), 3 (fatality 18.7%), 19A (fatality 12.5%), and 8 (fatality 7.2%). Serotype 3 was worrisome because it is associated with important fatality levels combined with very high incidence and mortality rates. Serotype 11A also showed a high fatality with marked incidence and mortality levels. Some few frequent serotypes as 31, 19F, and 15A despite its high fatality had low levels of mortality. By contrast other serotypes as 8 showing low fatality had high mortality ranges because it shows a wide extended distribution. Finally, common serotypes, such as 1 and 5, presented small mortality length, due to their low case-fatality rates.Sara De MiguelPello LatasaJosé YusteLuis GarcíaMaría OrdobásBelén RamosMarta PérezMaira Alejandra OrtizJuan Carlos SanzMDPI AGarticle<i>Streptococcus pneumoniae</i>invasive pneumococcal diseaseserotypevaccinefatalityBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2286, p 2286 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Streptococcus pneumoniae</i> invasive pneumococcal disease serotype vaccine fatality Biology (General) QH301-705.5
spellingShingle	<i>Streptococcus pneumoniae</i> invasive pneumococcal disease serotype vaccine fatality Biology (General) QH301-705.5 Sara De Miguel Pello Latasa José Yuste Luis García María Ordobás Belén Ramos Marta Pérez Maira Alejandra Ortiz Juan Carlos Sanz Age-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 2020
description	The aim of this study was to investigate the serotype-associated fatality rate in cases of invasive pneumococcal disease (IPD) in the Spanish region of Madrid between 2007 and 2020. Serotyping was performed by Pneumotest Latex and the Quellung reaction using commercial antisera. Case-fatality rate was estimated as the ratio between the number of deaths at hospital discharge and the number of cases attributable to each serotype. To evaluate the association measures, the odds ratios with a 95% confidence interval were calculated. Twenty five pneumococcal serotypes were associated to mortality and comprised 87.8% of the total number of isolates characterized. Serotypes 8, 3, 19A, 1, 7F, 22F, 12F, and 11A were the most prevalent (≥3% each). Serotypes 31, 11A, and 19F were significantly associated to high case-fatality rates (>20% each). The lower significantly associated case-fatality rate (<10% each) was found in serotypes 5, 1, 12B, 7F, 12F, 8, 33, and 10A. The serotypes with higher mortality levels (≥0.04 per 100,000 population) were 11A (fatality 24.0%), 3 (fatality 18.7%), 19A (fatality 12.5%), and 8 (fatality 7.2%). Serotype 3 was worrisome because it is associated with important fatality levels combined with very high incidence and mortality rates. Serotype 11A also showed a high fatality with marked incidence and mortality levels. Some few frequent serotypes as 31, 19F, and 15A despite its high fatality had low levels of mortality. By contrast other serotypes as 8 showing low fatality had high mortality ranges because it shows a wide extended distribution. Finally, common serotypes, such as 1 and 5, presented small mortality length, due to their low case-fatality rates.
format	article
author	Sara De Miguel Pello Latasa José Yuste Luis García María Ordobás Belén Ramos Marta Pérez Maira Alejandra Ortiz Juan Carlos Sanz
author_facet	Sara De Miguel Pello Latasa José Yuste Luis García María Ordobás Belén Ramos Marta Pérez Maira Alejandra Ortiz Juan Carlos Sanz
author_sort	Sara De Miguel
title	Age-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 2020
title_short	Age-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 2020
title_full	Age-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 2020
title_fullStr	Age-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 2020
title_full_unstemmed	Age-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 2020
title_sort	age-dependent serotype-associated case-fatality rate in invasive pneumococcal disease in the autonomous community of madrid between 2007 and 2020
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3629254e10c443f8ba30ed2868d7ddb0
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Age-Dependent Serotype-Associated Case-Fatality Rate in Invasive Pneumococcal Disease in the Autonomous Community of Madrid between 2007 and 2020

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