Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells

The chromatin remodeler Chd1 mediates hypertranscription in embryonic stem (ES) cells and has been shown to associate with genes transcribed by RNA Polymerase (Pol) I and II. Here the authors provide mechanistic insights into this process and reveal that Chd1 is involved in protecting genome integri...

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Autores principales:	Aydan Bulut-Karslioglu, Hu Jin, Yun-Kyo Kim, Brandon Cho, Marcela Guzman-Ayala, Andrew J. K. Williamson, Miroslav Hejna, Maximilian Stötzel, Anthony D. Whetton, Jun S. Song, Miguel Ramalho-Santos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/362975551fcb4640be6efa18d7a17af1
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spelling	oai:doaj.org-article:362975551fcb4640be6efa18d7a17af12021-12-02T16:28:01ZChd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells10.1038/s41467-021-25088-32041-1723https://doaj.org/article/362975551fcb4640be6efa18d7a17af12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25088-3https://doaj.org/toc/2041-1723The chromatin remodeler Chd1 mediates hypertranscription in embryonic stem (ES) cells and has been shown to associate with genes transcribed by RNA Polymerase (Pol) I and II. Here the authors provide mechanistic insights into this process and reveal that Chd1 is involved in protecting genome integrity at promoter regions by preventing DNA break accumulation.Aydan Bulut-KarsliogluHu JinYun-Kyo KimBrandon ChoMarcela Guzman-AyalaAndrew J. K. WilliamsonMiroslav HejnaMaximilian StötzelAnthony D. WhettonJun S. SongMiguel Ramalho-SantosNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aydan Bulut-Karslioglu Hu Jin Yun-Kyo Kim Brandon Cho Marcela Guzman-Ayala Andrew J. K. Williamson Miroslav Hejna Maximilian Stötzel Anthony D. Whetton Jun S. Song Miguel Ramalho-Santos Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
description	The chromatin remodeler Chd1 mediates hypertranscription in embryonic stem (ES) cells and has been shown to associate with genes transcribed by RNA Polymerase (Pol) I and II. Here the authors provide mechanistic insights into this process and reveal that Chd1 is involved in protecting genome integrity at promoter regions by preventing DNA break accumulation.
format	article
author	Aydan Bulut-Karslioglu Hu Jin Yun-Kyo Kim Brandon Cho Marcela Guzman-Ayala Andrew J. K. Williamson Miroslav Hejna Maximilian Stötzel Anthony D. Whetton Jun S. Song Miguel Ramalho-Santos
author_facet	Aydan Bulut-Karslioglu Hu Jin Yun-Kyo Kim Brandon Cho Marcela Guzman-Ayala Andrew J. K. Williamson Miroslav Hejna Maximilian Stötzel Anthony D. Whetton Jun S. Song Miguel Ramalho-Santos
author_sort	Aydan Bulut-Karslioglu
title	Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
title_short	Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
title_full	Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
title_fullStr	Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
title_full_unstemmed	Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
title_sort	chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/362975551fcb4640be6efa18d7a17af1
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Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells

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