Properties of a bovine collagen type I membrane for guided bone regeneration applications

Dental implant treatment requires an available bone volume in the implantation site to ensure the implant’s mechanical stability. When the bone volume is insufficient, one must resort to surgical means such as guided bone regeneration (GBR). In GBR surgery, bone grafts and membranes are used. The ob...

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Autores principales:	Brum Igor S., Elias Carlos N., de Carvalho Jorge J., Pires Jorge L. S., Pereira Mario J. S., de Biasi Ronaldo S.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	membrane collagen bone regeneration biomaterials Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/362d4ddce51149adbf32176c0a71d0dd
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spelling	oai:doaj.org-article:362d4ddce51149adbf32176c0a71d0dd2021-12-05T14:10:47ZProperties of a bovine collagen type I membrane for guided bone regeneration applications1618-722910.1515/epoly-2021-0021https://doaj.org/article/362d4ddce51149adbf32176c0a71d0dd2021-03-01T00:00:00Zhttps://doi.org/10.1515/epoly-2021-0021https://doaj.org/toc/1618-7229Dental implant treatment requires an available bone volume in the implantation site to ensure the implant’s mechanical stability. When the bone volume is insufficient, one must resort to surgical means such as guided bone regeneration (GBR). In GBR surgery, bone grafts and membranes are used. The objective of this work is to manufacture and characterize the in vitro and in vivo properties of resorbable collagen type I membranes (Green Membrane®) for GBR. Membrane surface morphology was characterized by SEM and roughness was measured using an interferometric noncontact 3D system. In vivo skin sensitization and toxicity tests have been performed on Wistar rats. Bone defects were prepared in 24 adult male rats, filled with biomaterials (Blue Bone® and Bio Oss®) and covered with collagen membranes to maintain the mechanical stability of the site for bone regeneration. The incisions were closed with simple stitches; and 60 days after the surgery, the animals were euthanized. Results showed that the analyzed membrane was homogeneous, with collagen fiber webs and open pores. It had no sign of cytotoxicity and the cells at the insertion site showed no bone morphological changes. There was no tissue reaction and no statistical difference between Blue Bone® and Bio Oss® groups. The proposed membrane has no cytotoxicity and displays a biocompatibility profile that makes it suitable for GBR.Brum Igor S.Elias Carlos N.de Carvalho Jorge J.Pires Jorge L. S.Pereira Mario J. S.de Biasi Ronaldo S.De Gruyterarticlemembranecollagenbone regenerationbiomaterialsPolymers and polymer manufactureTP1080-1185ENe-Polymers, Vol 21, Iss 1, Pp 210-221 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	membrane collagen bone regeneration biomaterials Polymers and polymer manufacture TP1080-1185
spellingShingle	membrane collagen bone regeneration biomaterials Polymers and polymer manufacture TP1080-1185 Brum Igor S. Elias Carlos N. de Carvalho Jorge J. Pires Jorge L. S. Pereira Mario J. S. de Biasi Ronaldo S. Properties of a bovine collagen type I membrane for guided bone regeneration applications
description	Dental implant treatment requires an available bone volume in the implantation site to ensure the implant’s mechanical stability. When the bone volume is insufficient, one must resort to surgical means such as guided bone regeneration (GBR). In GBR surgery, bone grafts and membranes are used. The objective of this work is to manufacture and characterize the in vitro and in vivo properties of resorbable collagen type I membranes (Green Membrane®) for GBR. Membrane surface morphology was characterized by SEM and roughness was measured using an interferometric noncontact 3D system. In vivo skin sensitization and toxicity tests have been performed on Wistar rats. Bone defects were prepared in 24 adult male rats, filled with biomaterials (Blue Bone® and Bio Oss®) and covered with collagen membranes to maintain the mechanical stability of the site for bone regeneration. The incisions were closed with simple stitches; and 60 days after the surgery, the animals were euthanized. Results showed that the analyzed membrane was homogeneous, with collagen fiber webs and open pores. It had no sign of cytotoxicity and the cells at the insertion site showed no bone morphological changes. There was no tissue reaction and no statistical difference between Blue Bone® and Bio Oss® groups. The proposed membrane has no cytotoxicity and displays a biocompatibility profile that makes it suitable for GBR.
format	article
author	Brum Igor S. Elias Carlos N. de Carvalho Jorge J. Pires Jorge L. S. Pereira Mario J. S. de Biasi Ronaldo S.
author_facet	Brum Igor S. Elias Carlos N. de Carvalho Jorge J. Pires Jorge L. S. Pereira Mario J. S. de Biasi Ronaldo S.
author_sort	Brum Igor S.
title	Properties of a bovine collagen type I membrane for guided bone regeneration applications
title_short	Properties of a bovine collagen type I membrane for guided bone regeneration applications
title_full	Properties of a bovine collagen type I membrane for guided bone regeneration applications
title_fullStr	Properties of a bovine collagen type I membrane for guided bone regeneration applications
title_full_unstemmed	Properties of a bovine collagen type I membrane for guided bone regeneration applications
title_sort	properties of a bovine collagen type i membrane for guided bone regeneration applications
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/362d4ddce51149adbf32176c0a71d0dd
work_keys_str_mv	AT brumigors propertiesofabovinecollagentypeimembraneforguidedboneregenerationapplications AT eliascarlosn propertiesofabovinecollagentypeimembraneforguidedboneregenerationapplications AT decarvalhojorgej propertiesofabovinecollagentypeimembraneforguidedboneregenerationapplications AT piresjorgels propertiesofabovinecollagentypeimembraneforguidedboneregenerationapplications AT pereiramariojs propertiesofabovinecollagentypeimembraneforguidedboneregenerationapplications AT debiasironaldos propertiesofabovinecollagentypeimembraneforguidedboneregenerationapplications
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Properties of a bovine collagen type I membrane for guided bone regeneration applications

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