Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells and the targeted upstream delivery to different target organs in mice, pigs and ex vivo human lungs.

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Autores principales:	Jacob S. Brenner, Daniel C. Pan, Jacob W. Myerson, Oscar A. Marcos-Contreras, Carlos H. Villa, Priyal Patel, Hugh Hekierski, Shampa Chatterjee, Jian-Qin Tao, Hamideh Parhiz, Kartik Bhamidipati, Thomas G. Uhler, Elizabeth D. Hood, Raisa Yu. Kiseleva, Vladimir S. Shuvaev, Tea Shuvaeva, Makan Khoshnejad, Ian Johnston, Jason V. Gregory, Joerg Lahann, Tao Wang, Edward Cantu, William M. Armstead, Samir Mitragotri, Vladimir Muzykantov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/362e0eed733347a8aa0df110774ccc31
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spelling	oai:doaj.org-article:362e0eed733347a8aa0df110774ccc312021-12-02T16:49:21ZRed blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude10.1038/s41467-018-05079-72041-1723https://doaj.org/article/362e0eed733347a8aa0df110774ccc312018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05079-7https://doaj.org/toc/2041-1723Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells and the targeted upstream delivery to different target organs in mice, pigs and ex vivo human lungs.Jacob S. BrennerDaniel C. PanJacob W. MyersonOscar A. Marcos-ContrerasCarlos H. VillaPriyal PatelHugh HekierskiShampa ChatterjeeJian-Qin TaoHamideh ParhizKartik BhamidipatiThomas G. UhlerElizabeth D. HoodRaisa Yu. KiselevaVladimir S. ShuvaevTea ShuvaevaMakan KhoshnejadIan JohnstonJason V. GregoryJoerg LahannTao WangEdward CantuWilliam M. ArmsteadSamir MitragotriVladimir MuzykantovNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacob S. Brenner Daniel C. Pan Jacob W. Myerson Oscar A. Marcos-Contreras Carlos H. Villa Priyal Patel Hugh Hekierski Shampa Chatterjee Jian-Qin Tao Hamideh Parhiz Kartik Bhamidipati Thomas G. Uhler Elizabeth D. Hood Raisa Yu. Kiseleva Vladimir S. Shuvaev Tea Shuvaeva Makan Khoshnejad Ian Johnston Jason V. Gregory Joerg Lahann Tao Wang Edward Cantu William M. Armstead Samir Mitragotri Vladimir Muzykantov Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
description	Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells and the targeted upstream delivery to different target organs in mice, pigs and ex vivo human lungs.
format	article
author	Jacob S. Brenner Daniel C. Pan Jacob W. Myerson Oscar A. Marcos-Contreras Carlos H. Villa Priyal Patel Hugh Hekierski Shampa Chatterjee Jian-Qin Tao Hamideh Parhiz Kartik Bhamidipati Thomas G. Uhler Elizabeth D. Hood Raisa Yu. Kiseleva Vladimir S. Shuvaev Tea Shuvaeva Makan Khoshnejad Ian Johnston Jason V. Gregory Joerg Lahann Tao Wang Edward Cantu William M. Armstead Samir Mitragotri Vladimir Muzykantov
author_facet	Jacob S. Brenner Daniel C. Pan Jacob W. Myerson Oscar A. Marcos-Contreras Carlos H. Villa Priyal Patel Hugh Hekierski Shampa Chatterjee Jian-Qin Tao Hamideh Parhiz Kartik Bhamidipati Thomas G. Uhler Elizabeth D. Hood Raisa Yu. Kiseleva Vladimir S. Shuvaev Tea Shuvaeva Makan Khoshnejad Ian Johnston Jason V. Gregory Joerg Lahann Tao Wang Edward Cantu William M. Armstead Samir Mitragotri Vladimir Muzykantov
author_sort	Jacob S. Brenner
title	Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
title_short	Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
title_full	Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
title_fullStr	Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
title_full_unstemmed	Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
title_sort	red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/362e0eed733347a8aa0df110774ccc31
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Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

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