Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.

<h4>Objective</h4>There is no universal consensus on the relationship between body mass index (BMI) and breast cancer. This meta-analysis was conducted to estimate the overall effect of overweight and obesity on breast cancer risk during pre- and post-menopausal period.<h4>Data sou...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zahra Cheraghi, Jalal Poorolajal, Tahereh Hashem, Nader Esmailnasab, Amin Doosti Irani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3632c4b8b9fb4a39b588315bcf3241c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3632c4b8b9fb4a39b588315bcf3241c1
record_format	dspace
spelling	oai:doaj.org-article:3632c4b8b9fb4a39b588315bcf3241c12021-11-18T08:05:54ZEffect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.1932-620310.1371/journal.pone.0051446https://doaj.org/article/3632c4b8b9fb4a39b588315bcf3241c12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23236502/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>There is no universal consensus on the relationship between body mass index (BMI) and breast cancer. This meta-analysis was conducted to estimate the overall effect of overweight and obesity on breast cancer risk during pre- and post-menopausal period.<h4>Data sources</h4>All major electronic databases were searched until April 2012 including Web of Knowledge, Medline, Scopus, and ScienceDirect. Furthermore, the reference lists and related scientific conference databases were searched.<h4>Review methods</h4>All prospective cohort and case-control studies investigating the association between BMI and breast cancer were retrieved irrespective of publication date and language. Women were assessed irrespective of age, race and marital status. The exposure of interest was BMI. The primary outcome of interest was all kinds of breast cancers confirmed pathologically. Study quality was assessed using the checklist of STROBE. Study selection and data extraction were performed by two authors separately. The effect measure of choice was risk ratio (RR(i)) and rate ratio (RR(a)) for cohort studies and odds ratio (OR) in case-control studies.<h4>Results</h4>Of 9163 retrieved studies, 50 studies were included in meta-analysis including 15 cohort studies involving 2,104,203 subjects and 3,414,806 person-years and 35 case-control studies involving 71,216 subjects. There was an inverse but non-significant correlation between BMI and breast cancer risk during premenopausal period: OR = 0.93 (95% CI 0.86, 1.02); RR(i) = 0.97 (95% CI 0.82, 1.16); and RR(a) = 0.99 (95% CI 0.94, 1.05), but a direct and significant correlation during postmenopausal period: OR = 1.15 (95% CI 1.07, 1.24); RR(i) = 1.16 (95% CI 1.08, 1.25); and RR(a) = 0.98 (95% CI 0.88, 1.09).<h4>Conclusion</h4>The results of this meta-analysis showed that body mass index has no significant effect on the incidence of breast cancer during premenopausal period. On the other hand, overweight and obesity may have a minimal effect on breast cancer, although significant, but really small and not clinically so important.Zahra CheraghiZahra CheraghiJalal PoorolajalTahereh HashemNader EsmailnasabAmin Doosti IraniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51446 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zahra Cheraghi Zahra Cheraghi Jalal Poorolajal Tahereh Hashem Nader Esmailnasab Amin Doosti Irani Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.
description	<h4>Objective</h4>There is no universal consensus on the relationship between body mass index (BMI) and breast cancer. This meta-analysis was conducted to estimate the overall effect of overweight and obesity on breast cancer risk during pre- and post-menopausal period.<h4>Data sources</h4>All major electronic databases were searched until April 2012 including Web of Knowledge, Medline, Scopus, and ScienceDirect. Furthermore, the reference lists and related scientific conference databases were searched.<h4>Review methods</h4>All prospective cohort and case-control studies investigating the association between BMI and breast cancer were retrieved irrespective of publication date and language. Women were assessed irrespective of age, race and marital status. The exposure of interest was BMI. The primary outcome of interest was all kinds of breast cancers confirmed pathologically. Study quality was assessed using the checklist of STROBE. Study selection and data extraction were performed by two authors separately. The effect measure of choice was risk ratio (RR(i)) and rate ratio (RR(a)) for cohort studies and odds ratio (OR) in case-control studies.<h4>Results</h4>Of 9163 retrieved studies, 50 studies were included in meta-analysis including 15 cohort studies involving 2,104,203 subjects and 3,414,806 person-years and 35 case-control studies involving 71,216 subjects. There was an inverse but non-significant correlation between BMI and breast cancer risk during premenopausal period: OR = 0.93 (95% CI 0.86, 1.02); RR(i) = 0.97 (95% CI 0.82, 1.16); and RR(a) = 0.99 (95% CI 0.94, 1.05), but a direct and significant correlation during postmenopausal period: OR = 1.15 (95% CI 1.07, 1.24); RR(i) = 1.16 (95% CI 1.08, 1.25); and RR(a) = 0.98 (95% CI 0.88, 1.09).<h4>Conclusion</h4>The results of this meta-analysis showed that body mass index has no significant effect on the incidence of breast cancer during premenopausal period. On the other hand, overweight and obesity may have a minimal effect on breast cancer, although significant, but really small and not clinically so important.
format	article
author	Zahra Cheraghi Zahra Cheraghi Jalal Poorolajal Tahereh Hashem Nader Esmailnasab Amin Doosti Irani
author_facet	Zahra Cheraghi Zahra Cheraghi Jalal Poorolajal Tahereh Hashem Nader Esmailnasab Amin Doosti Irani
author_sort	Zahra Cheraghi
title	Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.
title_short	Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.
title_full	Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.
title_fullStr	Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.
title_full_unstemmed	Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.
title_sort	effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3632c4b8b9fb4a39b588315bcf3241c1
work_keys_str_mv	AT zahracheraghi effectofbodymassindexonbreastcancerduringpremenopausalandpostmenopausalperiodsametaanalysis AT zahracheraghi effectofbodymassindexonbreastcancerduringpremenopausalandpostmenopausalperiodsametaanalysis AT jalalpoorolajal effectofbodymassindexonbreastcancerduringpremenopausalandpostmenopausalperiodsametaanalysis AT taherehhashem effectofbodymassindexonbreastcancerduringpremenopausalandpostmenopausalperiodsametaanalysis AT naderesmailnasab effectofbodymassindexonbreastcancerduringpremenopausalandpostmenopausalperiodsametaanalysis AT amindoostiirani effectofbodymassindexonbreastcancerduringpremenopausalandpostmenopausalperiodsametaanalysis
_version_	1718422221030948864

Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis.

Ejemplares similares