Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill
Doaa Alshora,1 Mohamed Ibrahim,1,2 Ehab Elzayat,1 Osaid T Almeanazel,1 Fars Alanazi11Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutics, College of Pharmacy, Al-Azhar University, Assi...
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Dove Medical Press
2019
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oai:doaj.org-article:3634a8aaf1c44a39a01976863631a1bf2021-12-02T08:53:09ZDefining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill1178-2013https://doaj.org/article/3634a8aaf1c44a39a01976863631a1bf2019-06-01T00:00:00Zhttps://www.dovepress.com/defining-the-process-parameters-affecting-the-fabrication-of-rosuvasta-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Doaa Alshora,1 Mohamed Ibrahim,1,2 Ehab Elzayat,1 Osaid T Almeanazel,1 Fars Alanazi11Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutics, College of Pharmacy, Al-Azhar University, Assiut, EgyptPurpose: Rosuvastatin calcium (ROSCa) nanoparticles were fabricated by planetary ball mill to enhance ROSCa dissolution rate and bioavailability.Methods: Milling time factors (milling cycle time and number as well as pause time) were explored. The effect of different milling ball size, speed, and solid-to-solvent ratio were also studied using Box–Behnken factorial design. The fabricated nanoparticles were evaluated in term of physicochemical properties and long-term stability.Results: The obtained data revealed that the integrated formulation and process factors should be monitored to obtain desirable nanoparticle attributes in terms of particle size, zeta potential, dissolution rate, and bioavailability. The optimized ROSCa nanoparticles prepared by milling technique showed a significant enhancement in the dissolution rate by 1.3-fold and the plasma concentration increased by 2-fold (P<0.05). Moreover, stability study showed that the optimized formula of ROSCa nanoparticles exhibits higher stability in long-term stability conditions at 30°C with humidity of 60%. Conclusion: Formulation of ROSCa as nanoparticles using milling technique showed a significant enhancement in both dissolution rate and plasma concentration as well as stability compared with untreated drug.Keywords: rosuvastatin calcium, nanoparticles, planetary ball mill, Box–Behnken, in vitro dissolution, stability, pharmacokineticsAlshora DIbrahim MElzayat EAlmeanazel OTAlanazi FDove Medical PressarticleRosuvastatin calciumNanoparticlesPlanetary ball millBox- BehnkenIn-vitro dissolutionStabilityPharmacokinetics.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4625-4636 (2019) |
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Rosuvastatin calcium Nanoparticles Planetary ball mill Box- Behnken In-vitro dissolution Stability Pharmacokinetics. Medicine (General) R5-920 |
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Rosuvastatin calcium Nanoparticles Planetary ball mill Box- Behnken In-vitro dissolution Stability Pharmacokinetics. Medicine (General) R5-920 Alshora D Ibrahim M Elzayat E Almeanazel OT Alanazi F Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill |
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Doaa Alshora,1 Mohamed Ibrahim,1,2 Ehab Elzayat,1 Osaid T Almeanazel,1 Fars Alanazi11Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutics, College of Pharmacy, Al-Azhar University, Assiut, EgyptPurpose: Rosuvastatin calcium (ROSCa) nanoparticles were fabricated by planetary ball mill to enhance ROSCa dissolution rate and bioavailability.Methods: Milling time factors (milling cycle time and number as well as pause time) were explored. The effect of different milling ball size, speed, and solid-to-solvent ratio were also studied using Box–Behnken factorial design. The fabricated nanoparticles were evaluated in term of physicochemical properties and long-term stability.Results: The obtained data revealed that the integrated formulation and process factors should be monitored to obtain desirable nanoparticle attributes in terms of particle size, zeta potential, dissolution rate, and bioavailability. The optimized ROSCa nanoparticles prepared by milling technique showed a significant enhancement in the dissolution rate by 1.3-fold and the plasma concentration increased by 2-fold (P<0.05). Moreover, stability study showed that the optimized formula of ROSCa nanoparticles exhibits higher stability in long-term stability conditions at 30°C with humidity of 60%. Conclusion: Formulation of ROSCa as nanoparticles using milling technique showed a significant enhancement in both dissolution rate and plasma concentration as well as stability compared with untreated drug.Keywords: rosuvastatin calcium, nanoparticles, planetary ball mill, Box–Behnken, in vitro dissolution, stability, pharmacokinetics |
format |
article |
author |
Alshora D Ibrahim M Elzayat E Almeanazel OT Alanazi F |
author_facet |
Alshora D Ibrahim M Elzayat E Almeanazel OT Alanazi F |
author_sort |
Alshora D |
title |
Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill |
title_short |
Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill |
title_full |
Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill |
title_fullStr |
Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill |
title_full_unstemmed |
Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill |
title_sort |
defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill |
publisher |
Dove Medical Press |
publishDate |
2019 |
url |
https://doaj.org/article/3634a8aaf1c44a39a01976863631a1bf |
work_keys_str_mv |
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