Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill

Doaa Alshora,1 Mohamed Ibrahim,1,2 Ehab Elzayat,1 Osaid T Almeanazel,1 Fars Alanazi11Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutics, College of Pharmacy, Al-Azhar University, Assi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Alshora D, Ibrahim M, Elzayat E, Almeanazel OT, Alanazi F
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://doaj.org/article/3634a8aaf1c44a39a01976863631a1bf
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:3634a8aaf1c44a39a01976863631a1bf
record_format dspace
spelling oai:doaj.org-article:3634a8aaf1c44a39a01976863631a1bf2021-12-02T08:53:09ZDefining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill1178-2013https://doaj.org/article/3634a8aaf1c44a39a01976863631a1bf2019-06-01T00:00:00Zhttps://www.dovepress.com/defining-the-process-parameters-affecting-the-fabrication-of-rosuvasta-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Doaa Alshora,1 Mohamed Ibrahim,1,2 Ehab Elzayat,1 Osaid T Almeanazel,1 Fars Alanazi11Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutics, College of Pharmacy, Al-Azhar University, Assiut, EgyptPurpose: Rosuvastatin calcium (ROSCa) nanoparticles were fabricated by planetary ball mill to enhance ROSCa dissolution rate and bioavailability.Methods: Milling time factors (milling cycle time and number as well as pause time) were explored. The effect of different milling ball size, speed, and solid-to-solvent ratio were also studied using Box–Behnken factorial design. The fabricated nanoparticles were evaluated in term of physicochemical properties and long-term stability.Results: The obtained data revealed that the integrated formulation and process factors should be monitored to obtain desirable nanoparticle attributes in terms of particle size, zeta potential, dissolution rate, and bioavailability. The optimized ROSCa nanoparticles prepared by milling technique showed a significant enhancement in the dissolution rate by 1.3-fold and the plasma concentration increased by 2-fold (P<0.05). Moreover, stability study showed that the optimized formula of ROSCa nanoparticles exhibits higher stability in long-term stability conditions at 30°C with humidity of 60%. Conclusion: Formulation of ROSCa as nanoparticles using milling technique showed a significant enhancement in both dissolution rate and plasma concentration as well as stability compared with untreated drug.Keywords: rosuvastatin calcium, nanoparticles, planetary ball mill, Box–Behnken, in vitro dissolution, stability, pharmacokineticsAlshora DIbrahim MElzayat EAlmeanazel OTAlanazi FDove Medical PressarticleRosuvastatin calciumNanoparticlesPlanetary ball millBox- BehnkenIn-vitro dissolutionStabilityPharmacokinetics.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4625-4636 (2019)
institution DOAJ
collection DOAJ
language EN
topic Rosuvastatin calcium
Nanoparticles
Planetary ball mill
Box- Behnken
In-vitro dissolution
Stability
Pharmacokinetics.
Medicine (General)
R5-920
spellingShingle Rosuvastatin calcium
Nanoparticles
Planetary ball mill
Box- Behnken
In-vitro dissolution
Stability
Pharmacokinetics.
Medicine (General)
R5-920
Alshora D
Ibrahim M
Elzayat E
Almeanazel OT
Alanazi F
Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill
description Doaa Alshora,1 Mohamed Ibrahim,1,2 Ehab Elzayat,1 Osaid T Almeanazel,1 Fars Alanazi11Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutics, College of Pharmacy, Al-Azhar University, Assiut, EgyptPurpose: Rosuvastatin calcium (ROSCa) nanoparticles were fabricated by planetary ball mill to enhance ROSCa dissolution rate and bioavailability.Methods: Milling time factors (milling cycle time and number as well as pause time) were explored. The effect of different milling ball size, speed, and solid-to-solvent ratio were also studied using Box–Behnken factorial design. The fabricated nanoparticles were evaluated in term of physicochemical properties and long-term stability.Results: The obtained data revealed that the integrated formulation and process factors should be monitored to obtain desirable nanoparticle attributes in terms of particle size, zeta potential, dissolution rate, and bioavailability. The optimized ROSCa nanoparticles prepared by milling technique showed a significant enhancement in the dissolution rate by 1.3-fold and the plasma concentration increased by 2-fold (P<0.05). Moreover, stability study showed that the optimized formula of ROSCa nanoparticles exhibits higher stability in long-term stability conditions at 30°C with humidity of 60%. Conclusion: Formulation of ROSCa as nanoparticles using milling technique showed a significant enhancement in both dissolution rate and plasma concentration as well as stability compared with untreated drug.Keywords: rosuvastatin calcium, nanoparticles, planetary ball mill, Box–Behnken, in vitro dissolution, stability, pharmacokinetics
format article
author Alshora D
Ibrahim M
Elzayat E
Almeanazel OT
Alanazi F
author_facet Alshora D
Ibrahim M
Elzayat E
Almeanazel OT
Alanazi F
author_sort Alshora D
title Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill
title_short Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill
title_full Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill
title_fullStr Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill
title_full_unstemmed Defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill
title_sort defining the process parameters affecting the fabrication of rosuvastatin calcium nanoparticles by planetary ball mill
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/3634a8aaf1c44a39a01976863631a1bf
work_keys_str_mv AT alshorad definingtheprocessparametersaffectingthefabricationofrosuvastatincalciumnanoparticlesbyplanetaryballmill
AT ibrahimm definingtheprocessparametersaffectingthefabricationofrosuvastatincalciumnanoparticlesbyplanetaryballmill
AT elzayate definingtheprocessparametersaffectingthefabricationofrosuvastatincalciumnanoparticlesbyplanetaryballmill
AT almeanazelot definingtheprocessparametersaffectingthefabricationofrosuvastatincalciumnanoparticlesbyplanetaryballmill
AT alanazif definingtheprocessparametersaffectingthefabricationofrosuvastatincalciumnanoparticlesbyplanetaryballmill
_version_ 1718398294126755840