Platelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: A comparative analytic study.

<h4>Background</h4>Platelet indices (PIs) are platelet parameters that are correlated with platelet activity. Despite being widely available, inexpensive, and feasible; their use in clinical settings is limited. Recently, we developed a new score (EgyDAS), which relies on PIs and assesse...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Safaa A A Khaled, Hamdy F F Mahmoud
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/363c68b98c704e6fa597933829b3b687
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:363c68b98c704e6fa597933829b3b687
record_format	dspace
spelling	oai:doaj.org-article:363c68b98c704e6fa597933829b3b6872021-12-02T20:06:15ZPlatelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: A comparative analytic study.1932-620310.1371/journal.pone.0257200https://doaj.org/article/363c68b98c704e6fa597933829b3b6872021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257200https://doaj.org/toc/1932-6203<h4>Background</h4>Platelet indices (PIs) are platelet parameters that are correlated with platelet activity. Despite being widely available, inexpensive, and feasible; their use in clinical settings is limited. Recently, we developed a new score (EgyDAS), which relies on PIs and assesses disease activity in rheumatoid arthritis (RA).<h4>Objectives</h4>This study explored the practicability and validity of EgyDAS in RA with ankle involvement, considering that ankle is neglected in the commonly used DAS28 score.<h4>Methods</h4>This comparative case-control study included 2-groups of RA patients, group1 (control): without and group 2: with ankle involvement.<h4>Results</h4>Ankle involvement in RA showed no gender or age differences, however, it was associated with higher platelet count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelet distribution width (PDW), visual analogue scale (VAS), tender joint count (TJC), and lower hemoglobin (Hb) and mean platelet volume (MPV). DAS28 categorized a higher proportion of patients to have high disease activity compared with EgyDAS; moreover, it did not detect those in remission in group 2 patients. Highly significant differences in the 2-scores were observed between the two groups. Further analyses revealed superiority of EgyDAS in assessing disease activity in group 2 patients. Finally, both scores were found correlated together in the study groups.<h4>Conclusions</h4>Over or underestimation of RA disease activity could occur when using DAS28. PIs were found correlated with ankle involvement in RA. PIs and EgyDAS are the best tools to assess disease activity in RA patients with ankle involvement. However, the study recommended the use of both scores together.Safaa A A KhaledHamdy F F MahmoudPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257200 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Safaa A A Khaled Hamdy F F Mahmoud Platelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: A comparative analytic study.
description	<h4>Background</h4>Platelet indices (PIs) are platelet parameters that are correlated with platelet activity. Despite being widely available, inexpensive, and feasible; their use in clinical settings is limited. Recently, we developed a new score (EgyDAS), which relies on PIs and assesses disease activity in rheumatoid arthritis (RA).<h4>Objectives</h4>This study explored the practicability and validity of EgyDAS in RA with ankle involvement, considering that ankle is neglected in the commonly used DAS28 score.<h4>Methods</h4>This comparative case-control study included 2-groups of RA patients, group1 (control): without and group 2: with ankle involvement.<h4>Results</h4>Ankle involvement in RA showed no gender or age differences, however, it was associated with higher platelet count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelet distribution width (PDW), visual analogue scale (VAS), tender joint count (TJC), and lower hemoglobin (Hb) and mean platelet volume (MPV). DAS28 categorized a higher proportion of patients to have high disease activity compared with EgyDAS; moreover, it did not detect those in remission in group 2 patients. Highly significant differences in the 2-scores were observed between the two groups. Further analyses revealed superiority of EgyDAS in assessing disease activity in group 2 patients. Finally, both scores were found correlated together in the study groups.<h4>Conclusions</h4>Over or underestimation of RA disease activity could occur when using DAS28. PIs were found correlated with ankle involvement in RA. PIs and EgyDAS are the best tools to assess disease activity in RA patients with ankle involvement. However, the study recommended the use of both scores together.
format	article
author	Safaa A A Khaled Hamdy F F Mahmoud
author_facet	Safaa A A Khaled Hamdy F F Mahmoud
author_sort	Safaa A A Khaled
title	Platelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: A comparative analytic study.
title_short	Platelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: A comparative analytic study.
title_full	Platelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: A comparative analytic study.
title_fullStr	Platelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: A comparative analytic study.
title_full_unstemmed	Platelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: A comparative analytic study.
title_sort	platelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: a comparative analytic study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/363c68b98c704e6fa597933829b3b687
work_keys_str_mv	AT safaaaakhaled plateletindicesparametersinthenewdiseaseactivityscoreofrheumatoidarthritiswithankleinvolvementacomparativeanalyticstudy AT hamdyffmahmoud plateletindicesparametersinthenewdiseaseactivityscoreofrheumatoidarthritiswithankleinvolvementacomparativeanalyticstudy
_version_	1718375416899567616

Platelet indices parameters in the new disease activity score of rheumatoid arthritis with ankle involvement: A comparative analytic study.

Ejemplares similares