Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series

Justyna Klos-Rola, Maria Tulidowicz-Bielak, Tomasz Zarnowski Department of Ophthalmology, Medical University of Lublin, Lublin, Poland Background: The aim of this study was to evaluate the influence of topical bevacizumab on the formation and function of filtering blebs in eyes with early bleb failu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Klos-Rola J, Tulidowicz-Bielak M, Zarnowski T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/3641223bb54e4c73a50e5d624d055c67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3641223bb54e4c73a50e5d624d055c67
record_format	dspace
spelling	oai:doaj.org-article:3641223bb54e4c73a50e5d624d055c672021-12-02T02:22:02ZEffects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series1177-54671177-5483https://doaj.org/article/3641223bb54e4c73a50e5d624d055c672013-09-01T00:00:00Zhttp://www.dovepress.com/effects-of-topical-bevacizumab-application-on-early-bleb-failure-after-a14473https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Justyna Klos-Rola, Maria Tulidowicz-Bielak, Tomasz Zarnowski Department of Ophthalmology, Medical University of Lublin, Lublin, Poland Background: The aim of this study was to evaluate the influence of topical bevacizumab on the formation and function of filtering blebs in eyes with early bleb failure after antiglaucoma surgery. Methods: Of all patients who underwent mitomycin-augmented trabeculectomy for glaucoma in the Department of Ophthalmology at the Medical University in Lublin, Poland, between March 2009 and March 2010, a total of 21 eyes from 20 patients with injected filtration bleb 9.8 ± 4.7 days after surgery were included in this observational case series. All patients were treated with standard steroid therapy and topical bevacizumab 5 mg/mL five times a day for 20.9 ± 9.8 days. Patients were followed up every other day, and a full eye examination was performed 14, 30, 60, and 180 days after initiation of treatment. Blebs were evaluated for vascularity by slit-lamp examination with concomitant photographic documentation and intraocular pressure measurement. Results: Elevated functional bleb with significantly reduced vascularity was present in 16 eyes, and was flat and nonfunctional in five eyes. Intraocular pressure in all eyes decreased from a mean of 26.6 ± 9.6 mmHg before surgery to 14.6 ± 7.7 mmHg and 15.8 ± 8.3 mmHg at 2 and 6 months after surgery, respectively. Filtration bleb leak was noted in three eyes while on treatment with bevacizumab. Conclusion: Topical application of bevacizumab might favor functional bleb formation after trabeculectomy in eyes with a high risk of failure. Keywords: glaucoma, trabeculectomy, bleb failure, bevacizumabKlos-Rola JTulidowicz-Bielak MZarnowski TDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1929-1935 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Klos-Rola J Tulidowicz-Bielak M Zarnowski T Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series
description	Justyna Klos-Rola, Maria Tulidowicz-Bielak, Tomasz Zarnowski Department of Ophthalmology, Medical University of Lublin, Lublin, Poland Background: The aim of this study was to evaluate the influence of topical bevacizumab on the formation and function of filtering blebs in eyes with early bleb failure after antiglaucoma surgery. Methods: Of all patients who underwent mitomycin-augmented trabeculectomy for glaucoma in the Department of Ophthalmology at the Medical University in Lublin, Poland, between March 2009 and March 2010, a total of 21 eyes from 20 patients with injected filtration bleb 9.8 ± 4.7 days after surgery were included in this observational case series. All patients were treated with standard steroid therapy and topical bevacizumab 5 mg/mL five times a day for 20.9 ± 9.8 days. Patients were followed up every other day, and a full eye examination was performed 14, 30, 60, and 180 days after initiation of treatment. Blebs were evaluated for vascularity by slit-lamp examination with concomitant photographic documentation and intraocular pressure measurement. Results: Elevated functional bleb with significantly reduced vascularity was present in 16 eyes, and was flat and nonfunctional in five eyes. Intraocular pressure in all eyes decreased from a mean of 26.6 ± 9.6 mmHg before surgery to 14.6 ± 7.7 mmHg and 15.8 ± 8.3 mmHg at 2 and 6 months after surgery, respectively. Filtration bleb leak was noted in three eyes while on treatment with bevacizumab. Conclusion: Topical application of bevacizumab might favor functional bleb formation after trabeculectomy in eyes with a high risk of failure. Keywords: glaucoma, trabeculectomy, bleb failure, bevacizumab
format	article
author	Klos-Rola J Tulidowicz-Bielak M Zarnowski T
author_facet	Klos-Rola J Tulidowicz-Bielak M Zarnowski T
author_sort	Klos-Rola J
title	Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series
title_short	Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series
title_full	Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series
title_fullStr	Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series
title_full_unstemmed	Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series
title_sort	effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/3641223bb54e4c73a50e5d624d055c67
work_keys_str_mv	AT klosrolaj effectsoftopicalbevacizumabapplicationonearlyblebfailureaftertrabeculectomyobservationalcaseseries AT tulidowiczbielakm effectsoftopicalbevacizumabapplicationonearlyblebfailureaftertrabeculectomyobservationalcaseseries AT zarnowskit effectsoftopicalbevacizumabapplicationonearlyblebfailureaftertrabeculectomyobservationalcaseseries
_version_	1718402519588143104

Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series

Ejemplares similares