Extracellular Vesicles in Airway Homeostasis and Pathophysiology

The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the inner...

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Autores principales:	Alberto Fucarino, Alessandro Pitruzzella, Stefano Burgio, Maria Concetta Zarcone, Domenico Michele Modica, Francesco Cappello, Fabio Bucchieri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	asthma chronic obstructive pulmonary disease COPD epithelial–mesenchymal trophic unit muco-microbiotic layer nanovesicles Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/36433722b97a40948531390c7bebf182
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spelling	oai:doaj.org-article:36433722b97a40948531390c7bebf1822021-11-11T15:01:50ZExtracellular Vesicles in Airway Homeostasis and Pathophysiology10.3390/app112199332076-3417https://doaj.org/article/36433722b97a40948531390c7bebf1822021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/9933https://doaj.org/toc/2076-3417The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, including inflammatory ones. How nanovesicles produced by EMTU and MML may affect the airway integrity, leading to the onset of asthma and COPD, as well as their putative use in therapy will be discussed here.Alberto FucarinoAlessandro PitruzzellaStefano BurgioMaria Concetta ZarconeDomenico Michele ModicaFrancesco CappelloFabio BucchieriMDPI AGarticleasthmachronic obstructive pulmonary diseaseCOPDepithelial–mesenchymal trophic unitmuco-microbiotic layernanovesiclesTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 9933, p 9933 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	asthma chronic obstructive pulmonary disease COPD epithelial–mesenchymal trophic unit muco-microbiotic layer nanovesicles Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	asthma chronic obstructive pulmonary disease COPD epithelial–mesenchymal trophic unit muco-microbiotic layer nanovesicles Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Alberto Fucarino Alessandro Pitruzzella Stefano Burgio Maria Concetta Zarcone Domenico Michele Modica Francesco Cappello Fabio Bucchieri Extracellular Vesicles in Airway Homeostasis and Pathophysiology
description	The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, including inflammatory ones. How nanovesicles produced by EMTU and MML may affect the airway integrity, leading to the onset of asthma and COPD, as well as their putative use in therapy will be discussed here.
format	article
author	Alberto Fucarino Alessandro Pitruzzella Stefano Burgio Maria Concetta Zarcone Domenico Michele Modica Francesco Cappello Fabio Bucchieri
author_facet	Alberto Fucarino Alessandro Pitruzzella Stefano Burgio Maria Concetta Zarcone Domenico Michele Modica Francesco Cappello Fabio Bucchieri
author_sort	Alberto Fucarino
title	Extracellular Vesicles in Airway Homeostasis and Pathophysiology
title_short	Extracellular Vesicles in Airway Homeostasis and Pathophysiology
title_full	Extracellular Vesicles in Airway Homeostasis and Pathophysiology
title_fullStr	Extracellular Vesicles in Airway Homeostasis and Pathophysiology
title_full_unstemmed	Extracellular Vesicles in Airway Homeostasis and Pathophysiology
title_sort	extracellular vesicles in airway homeostasis and pathophysiology
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/36433722b97a40948531390c7bebf182
work_keys_str_mv	AT albertofucarino extracellularvesiclesinairwayhomeostasisandpathophysiology AT alessandropitruzzella extracellularvesiclesinairwayhomeostasisandpathophysiology AT stefanoburgio extracellularvesiclesinairwayhomeostasisandpathophysiology AT mariaconcettazarcone extracellularvesiclesinairwayhomeostasisandpathophysiology AT domenicomichelemodica extracellularvesiclesinairwayhomeostasisandpathophysiology AT francescocappello extracellularvesiclesinairwayhomeostasisandpathophysiology AT fabiobucchieri extracellularvesiclesinairwayhomeostasisandpathophysiology
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Extracellular Vesicles in Airway Homeostasis and Pathophysiology

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