Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats

Abstract Background Pleurotus tuber-regium (P.T) is an edible mushroom with abundant polysaccharides that has been used in traditional medicine to treat diabetes mellitus. This study investigated the hypoglycaemic potential and ameliorative activity of Pleurotus tuber-regium incorporated diet on dia...

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Autores principales:	Akindele Oluwatosin Adeyi, Folasade Ajoke Adams, Clementina Oyinkansola Adenipekun
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Pleurotus tuber-regium Type 2 diabetes mellitus Dyslipidaemia Diet Obesity Streptozotocin Medicine R Homeopathy RX1-681
Acceso en línea:	https://doaj.org/article/36443d3c559143759d1d2fbb8df170dd
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spelling	oai:doaj.org-article:36443d3c559143759d1d2fbb8df170dd2021-11-14T12:27:25ZPleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats10.1186/s40816-021-00321-02199-1197https://doaj.org/article/36443d3c559143759d1d2fbb8df170dd2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40816-021-00321-0https://doaj.org/toc/2199-1197Abstract Background Pleurotus tuber-regium (P.T) is an edible mushroom with abundant polysaccharides that has been used in traditional medicine to treat diabetes mellitus. This study investigated the hypoglycaemic potential and ameliorative activity of Pleurotus tuber-regium incorporated diet on diabetes induced dyslipidaemia. Materials and methods Thirty five (35) adult male wistar rats were randomly assigned to seven groups; Normal control, diabetic control, obese control, obese diabetic control, 10% PT, 20% PT, and Drug control. Type II DM was induced by placing the animals on high fat diet for a period of 10 weeks and a single intraperitoneal injection of streptozotocin (50 mg/kg/BW). P. T was incorporated into the feed and given to the animals for two weeks daily after the confirmation of diabetes. Results Treatment of the obese diabetic rats with P. T supplemented diet caused a decrease in the blood glucose level compared to the control groups. Increased organo-somatic ratio of the kidney and heart were markedly (p < 0.05) reduced following treatment (20% P.T). Furthermore, cholesterol, triglycerides, LDL-C and VLDL-C levels were reduced due to treatment accompanied by increased HDL-C in the liver. Histological evaluation of the liver, kidney, heart, and pancreas of the P. T treated groups were comparable to normal. Conclusion Incorporation of P. tuber-regium in diets could be effective in reversing dyslipidaemia in obese diabetic patients.Akindele Oluwatosin AdeyiFolasade Ajoke AdamsClementina Oyinkansola AdenipekunSpringerOpenarticlePleurotus tuber-regiumType 2 diabetes mellitusDyslipidaemiaDietObesityStreptozotocinMedicineRHomeopathyRX1-681ENClinical Phytoscience, Vol 7, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pleurotus tuber-regium Type 2 diabetes mellitus Dyslipidaemia Diet Obesity Streptozotocin Medicine R Homeopathy RX1-681
spellingShingle	Pleurotus tuber-regium Type 2 diabetes mellitus Dyslipidaemia Diet Obesity Streptozotocin Medicine R Homeopathy RX1-681 Akindele Oluwatosin Adeyi Folasade Ajoke Adams Clementina Oyinkansola Adenipekun Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats
description	Abstract Background Pleurotus tuber-regium (P.T) is an edible mushroom with abundant polysaccharides that has been used in traditional medicine to treat diabetes mellitus. This study investigated the hypoglycaemic potential and ameliorative activity of Pleurotus tuber-regium incorporated diet on diabetes induced dyslipidaemia. Materials and methods Thirty five (35) adult male wistar rats were randomly assigned to seven groups; Normal control, diabetic control, obese control, obese diabetic control, 10% PT, 20% PT, and Drug control. Type II DM was induced by placing the animals on high fat diet for a period of 10 weeks and a single intraperitoneal injection of streptozotocin (50 mg/kg/BW). P. T was incorporated into the feed and given to the animals for two weeks daily after the confirmation of diabetes. Results Treatment of the obese diabetic rats with P. T supplemented diet caused a decrease in the blood glucose level compared to the control groups. Increased organo-somatic ratio of the kidney and heart were markedly (p < 0.05) reduced following treatment (20% P.T). Furthermore, cholesterol, triglycerides, LDL-C and VLDL-C levels were reduced due to treatment accompanied by increased HDL-C in the liver. Histological evaluation of the liver, kidney, heart, and pancreas of the P. T treated groups were comparable to normal. Conclusion Incorporation of P. tuber-regium in diets could be effective in reversing dyslipidaemia in obese diabetic patients.
format	article
author	Akindele Oluwatosin Adeyi Folasade Ajoke Adams Clementina Oyinkansola Adenipekun
author_facet	Akindele Oluwatosin Adeyi Folasade Ajoke Adams Clementina Oyinkansola Adenipekun
author_sort	Akindele Oluwatosin Adeyi
title	Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats
title_short	Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats
title_full	Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats
title_fullStr	Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats
title_full_unstemmed	Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats
title_sort	pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/36443d3c559143759d1d2fbb8df170dd
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Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats

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