Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

Self-renewal of cancer stem cells can contribute to glioma progression. Here, the authors show that Notch1 activation in glioma stem cells induces expression of the lncRNATUG1, which promotes self-renewal through the repression of differentiation genes, and that targeting TUG1 represses glioma growt...

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Autores principales:	Keisuke Katsushima, Atsushi Natsume, Fumiharu Ohka, Keiko Shinjo, Akira Hatanaka, Norihisa Ichimura, Shinya Sato, Satoru Takahashi, Hiroshi Kimura, Yasushi Totoki, Tatsuhiro Shibata, Mitsuru Naito, Hyun Jin Kim, Kanjiro Miyata, Kazunori Kataoka, Yutaka Kondo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36464f0713394d1ea6623709d1ee83d9
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spelling	oai:doaj.org-article:36464f0713394d1ea6623709d1ee83d92021-12-02T16:57:28ZTargeting the Notch-regulated non-coding RNA TUG1 for glioma treatment10.1038/ncomms136162041-1723https://doaj.org/article/36464f0713394d1ea6623709d1ee83d92016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13616https://doaj.org/toc/2041-1723Self-renewal of cancer stem cells can contribute to glioma progression. Here, the authors show that Notch1 activation in glioma stem cells induces expression of the lncRNATUG1, which promotes self-renewal through the repression of differentiation genes, and that targeting TUG1 represses glioma growth in vivo.Keisuke KatsushimaAtsushi NatsumeFumiharu OhkaKeiko ShinjoAkira HatanakaNorihisa IchimuraShinya SatoSatoru TakahashiHiroshi KimuraYasushi TotokiTatsuhiro ShibataMitsuru NaitoHyun Jin KimKanjiro MiyataKazunori KataokaYutaka KondoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keisuke Katsushima Atsushi Natsume Fumiharu Ohka Keiko Shinjo Akira Hatanaka Norihisa Ichimura Shinya Sato Satoru Takahashi Hiroshi Kimura Yasushi Totoki Tatsuhiro Shibata Mitsuru Naito Hyun Jin Kim Kanjiro Miyata Kazunori Kataoka Yutaka Kondo Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
description	Self-renewal of cancer stem cells can contribute to glioma progression. Here, the authors show that Notch1 activation in glioma stem cells induces expression of the lncRNATUG1, which promotes self-renewal through the repression of differentiation genes, and that targeting TUG1 represses glioma growth in vivo.
format	article
author	Keisuke Katsushima Atsushi Natsume Fumiharu Ohka Keiko Shinjo Akira Hatanaka Norihisa Ichimura Shinya Sato Satoru Takahashi Hiroshi Kimura Yasushi Totoki Tatsuhiro Shibata Mitsuru Naito Hyun Jin Kim Kanjiro Miyata Kazunori Kataoka Yutaka Kondo
author_facet	Keisuke Katsushima Atsushi Natsume Fumiharu Ohka Keiko Shinjo Akira Hatanaka Norihisa Ichimura Shinya Sato Satoru Takahashi Hiroshi Kimura Yasushi Totoki Tatsuhiro Shibata Mitsuru Naito Hyun Jin Kim Kanjiro Miyata Kazunori Kataoka Yutaka Kondo
author_sort	Keisuke Katsushima
title	Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
title_short	Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
title_full	Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
title_fullStr	Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
title_full_unstemmed	Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
title_sort	targeting the notch-regulated non-coding rna tug1 for glioma treatment
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/36464f0713394d1ea6623709d1ee83d9
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Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

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