Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort

Alissar El Chediak,1 Raafat S Alameddine,1 Ayman Hakim,1 Lara Hilal,2 Sarah Abdel Massih,1 Lana Hamieh,3 Deborah Mukherji,1 Sally Temraz,1 Maya Charafeddine,1 Ali Shamseddine1 1Division of Hematology/Oncology, Department of Internal Medicine, 2Department of Radiation Oncology, American University of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	El Chediak A, Alameddine RS, Hakim A, Hilal L, Abdel Massih S, Hamieh L, Mukherji D, Temraz S, Charafeddine M, Shamseddine A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Young breast cancer age subtypes disease free survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/36479cf8004b49c7a76b396c59caa292
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:36479cf8004b49c7a76b396c59caa292
record_format	dspace
spelling	oai:doaj.org-article:36479cf8004b49c7a76b396c59caa2922021-12-02T03:10:09ZYounger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort1179-1314https://doaj.org/article/36479cf8004b49c7a76b396c59caa2922017-06-01T00:00:00Zhttps://www.dovepress.com/younger-age-is-an-independent-predictor-of-worse-prognosis-among-leban-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Alissar El Chediak,1 Raafat S Alameddine,1 Ayman Hakim,1 Lara Hilal,2 Sarah Abdel Massih,1 Lana Hamieh,3 Deborah Mukherji,1 Sally Temraz,1 Maya Charafeddine,1 Ali Shamseddine1 1Division of Hematology/Oncology, Department of Internal Medicine, 2Department of Radiation Oncology, American University of Beirut Medical Center, Beirut, Lebanon; 3Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, USA Background: Several retrospective studies have reported that younger age at presentation is associated with a worse prognosis for nonmetastatic breast cancer patients. In this study, we prospectively assessed the association between different baseline characteristics (age, tumor characteristics, mode of treatment, etc) and outcomes among newly diagnosed nonmetastatic Lebanese breast cancer patients.Methods: We recruited a sample of 123 women newly diagnosed with nonmetastatic breast cancer presenting to American University of Beirut Medical Center. Immunohistochemical, molecular (vitamin D receptor, methylene tetrahydrofolate reductase polymorphisms), and genetic assays were performed. Patient characteristics were compared by age group (<40 and ≥40 years). A Cox regression analysis was performed to evaluate the variables affecting the disease-free survival (DFS). Outcome data were obtained, and DFS was estimated.Results: Among the 123 patients, 47 were 40 years of age or younger, and 76 were older than 40 years. Median follow-up duration was 58 months. Nine out of 47 patients <40 years (19.1%) experienced disease relapse in contrast to four out of 76 patients >40 years (5.2%). A wide immunohistochemical panel included Ki-67, cyclin B1, p53, platelet-derived growth factor receptor, and vascular endothelial growth factor receptor, and did not reveal any significant difference in these markers between the two age groups. Older patients had a larger percentage of Luminal A than younger patients. On multivariate analysis including age, stage, grade, and subtype, only age <40 and stage were significantly associated with shorter DFS with hazard ratios of 4 (p=0.03, 95% confidence interval [CI]: 1.1–13.5) and 3 (p=0.03, 95% CI: 0.8–14.9), respectively. The estimated 5-year DFS for patients >40 years was 90%, and for patients <40 years was 37%.Conclusion: Being <40 years old was an independent risk factor for recurrence in this cohort of patients. Keywords: young, subtypes, disease-free survival, worse prognosis, early, risk factorEl Chediak AAlameddine RSHakim AHilal LAbdel Massih SHamieh LMukherji DTemraz SCharafeddine MShamseddine ADove Medical PressarticleYoungbreast canceragesubtypesdisease free survivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 407-414 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Young breast cancer age subtypes disease free survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Young breast cancer age subtypes disease free survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 El Chediak A Alameddine RS Hakim A Hilal L Abdel Massih S Hamieh L Mukherji D Temraz S Charafeddine M Shamseddine A Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort
description	Alissar El Chediak,1 Raafat S Alameddine,1 Ayman Hakim,1 Lara Hilal,2 Sarah Abdel Massih,1 Lana Hamieh,3 Deborah Mukherji,1 Sally Temraz,1 Maya Charafeddine,1 Ali Shamseddine1 1Division of Hematology/Oncology, Department of Internal Medicine, 2Department of Radiation Oncology, American University of Beirut Medical Center, Beirut, Lebanon; 3Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, USA Background: Several retrospective studies have reported that younger age at presentation is associated with a worse prognosis for nonmetastatic breast cancer patients. In this study, we prospectively assessed the association between different baseline characteristics (age, tumor characteristics, mode of treatment, etc) and outcomes among newly diagnosed nonmetastatic Lebanese breast cancer patients.Methods: We recruited a sample of 123 women newly diagnosed with nonmetastatic breast cancer presenting to American University of Beirut Medical Center. Immunohistochemical, molecular (vitamin D receptor, methylene tetrahydrofolate reductase polymorphisms), and genetic assays were performed. Patient characteristics were compared by age group (<40 and ≥40 years). A Cox regression analysis was performed to evaluate the variables affecting the disease-free survival (DFS). Outcome data were obtained, and DFS was estimated.Results: Among the 123 patients, 47 were 40 years of age or younger, and 76 were older than 40 years. Median follow-up duration was 58 months. Nine out of 47 patients <40 years (19.1%) experienced disease relapse in contrast to four out of 76 patients >40 years (5.2%). A wide immunohistochemical panel included Ki-67, cyclin B1, p53, platelet-derived growth factor receptor, and vascular endothelial growth factor receptor, and did not reveal any significant difference in these markers between the two age groups. Older patients had a larger percentage of Luminal A than younger patients. On multivariate analysis including age, stage, grade, and subtype, only age <40 and stage were significantly associated with shorter DFS with hazard ratios of 4 (p=0.03, 95% confidence interval [CI]: 1.1–13.5) and 3 (p=0.03, 95% CI: 0.8–14.9), respectively. The estimated 5-year DFS for patients >40 years was 90%, and for patients <40 years was 37%.Conclusion: Being <40 years old was an independent risk factor for recurrence in this cohort of patients. Keywords: young, subtypes, disease-free survival, worse prognosis, early, risk factor
format	article
author	El Chediak A Alameddine RS Hakim A Hilal L Abdel Massih S Hamieh L Mukherji D Temraz S Charafeddine M Shamseddine A
author_facet	El Chediak A Alameddine RS Hakim A Hilal L Abdel Massih S Hamieh L Mukherji D Temraz S Charafeddine M Shamseddine A
author_sort	El Chediak A
title	Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort
title_short	Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort
title_full	Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort
title_fullStr	Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort
title_full_unstemmed	Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort
title_sort	younger age is an independent predictor of worse prognosis among lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/36479cf8004b49c7a76b396c59caa292
work_keys_str_mv	AT elchediaka youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort AT alameddiners youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort AT hakima youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort AT hilall youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort AT abdelmassihs youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort AT hamiehl youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort AT mukherjid youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort AT temrazs youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort AT charafeddinem youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort AT shamseddinea youngerageisanindependentpredictorofworseprognosisamonglebanesenonmetastaticbreastcancerpatientsanalysisofaprospectivecohort
_version_	1718401910079225856

Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort

Ejemplares similares