Ocular direct current stimulation affects retinal ganglion cells

Abstract Ocular current stimulation (oCS) with weak current intensities (a few mA) has shown positive effects on retinal nerve cells, which indicates that neurodegenerative ocular diseases could be treated with current stimulation of the eye. During oCS, a significant polarity-independent reduction...

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Autores principales:	Maren-Christina Blum, Alexander Hunold, Benjamin Solf, Sascha Klee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3647d99dc0aa41b3bdd1cdcdda0cd3f4
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spelling	oai:doaj.org-article:3647d99dc0aa41b3bdd1cdcdda0cd3f42021-12-02T19:04:36ZOcular direct current stimulation affects retinal ganglion cells10.1038/s41598-021-96401-92045-2322https://doaj.org/article/3647d99dc0aa41b3bdd1cdcdda0cd3f42021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96401-9https://doaj.org/toc/2045-2322Abstract Ocular current stimulation (oCS) with weak current intensities (a few mA) has shown positive effects on retinal nerve cells, which indicates that neurodegenerative ocular diseases could be treated with current stimulation of the eye. During oCS, a significant polarity-independent reduction in the characteristic P50 amplitude of a pattern-reversal electroretinogram was found, while no current stimulation effect was found for a full field electroretinogram (ffERG). The ffERG data indicated a trend for a polarity-dependent influence during oCS on the photopic negative response (PhNR) wave, which represents the sum activity of the retinal ganglion cells. Therefore, an ffERG with adjusted parameters for the standardized measurement of the PhNR wave was combined with simultaneous oCS to study the potential effects of direct oCS on cumulative ganglion cell activity. Compared with that measured before oCS, the PhNR amplitude in the cathodal group increased significantly during current stimulation, while in the anodal and sham groups, no effect was visible (α = 0.05, pcathodal = 0.006). Furthermore, repeated-measures ANOVA revealed a significant difference in PhNR amplitude between the anodal and cathodal groups as well as between the cathodal and sham groups (p ≤ 0.0167, pcathodal − anodal = 0.002, pcathodal − sham = 0.011).Maren-Christina BlumAlexander HunoldBenjamin SolfSascha KleeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maren-Christina Blum Alexander Hunold Benjamin Solf Sascha Klee Ocular direct current stimulation affects retinal ganglion cells
description	Abstract Ocular current stimulation (oCS) with weak current intensities (a few mA) has shown positive effects on retinal nerve cells, which indicates that neurodegenerative ocular diseases could be treated with current stimulation of the eye. During oCS, a significant polarity-independent reduction in the characteristic P50 amplitude of a pattern-reversal electroretinogram was found, while no current stimulation effect was found for a full field electroretinogram (ffERG). The ffERG data indicated a trend for a polarity-dependent influence during oCS on the photopic negative response (PhNR) wave, which represents the sum activity of the retinal ganglion cells. Therefore, an ffERG with adjusted parameters for the standardized measurement of the PhNR wave was combined with simultaneous oCS to study the potential effects of direct oCS on cumulative ganglion cell activity. Compared with that measured before oCS, the PhNR amplitude in the cathodal group increased significantly during current stimulation, while in the anodal and sham groups, no effect was visible (α = 0.05, pcathodal = 0.006). Furthermore, repeated-measures ANOVA revealed a significant difference in PhNR amplitude between the anodal and cathodal groups as well as between the cathodal and sham groups (p ≤ 0.0167, pcathodal − anodal = 0.002, pcathodal − sham = 0.011).
format	article
author	Maren-Christina Blum Alexander Hunold Benjamin Solf Sascha Klee
author_facet	Maren-Christina Blum Alexander Hunold Benjamin Solf Sascha Klee
author_sort	Maren-Christina Blum
title	Ocular direct current stimulation affects retinal ganglion cells
title_short	Ocular direct current stimulation affects retinal ganglion cells
title_full	Ocular direct current stimulation affects retinal ganglion cells
title_fullStr	Ocular direct current stimulation affects retinal ganglion cells
title_full_unstemmed	Ocular direct current stimulation affects retinal ganglion cells
title_sort	ocular direct current stimulation affects retinal ganglion cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3647d99dc0aa41b3bdd1cdcdda0cd3f4
work_keys_str_mv	AT marenchristinablum oculardirectcurrentstimulationaffectsretinalganglioncells AT alexanderhunold oculardirectcurrentstimulationaffectsretinalganglioncells AT benjaminsolf oculardirectcurrentstimulationaffectsretinalganglioncells AT saschaklee oculardirectcurrentstimulationaffectsretinalganglioncells
_version_	1718377202466160640

Ocular direct current stimulation affects retinal ganglion cells

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