Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women

Abstract Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among predominantly premenopausal women of the Nurses...

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Autores principales:	Oana A. Zeleznik, Raji Balasubramanian, Yibai Zhao, Lisa Frueh, Sarah Jeanfavre, Julian Avila-Pacheco, Clary B. Clish, Shelley S. Tworoger, A. Heather Eliassen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/364911554b85499280a193b48fdf7611
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spelling	oai:doaj.org-article:364911554b85499280a193b48fdf76112021-12-02T15:53:06ZCirculating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women10.1038/s41523-021-00262-42374-4677https://doaj.org/article/364911554b85499280a193b48fdf76112021-05-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00262-4https://doaj.org/toc/2374-4677Abstract Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among predominantly premenopausal women of the Nurses’ Health Study II using conditional logistic regression (1057 cases, 1057 controls) and multivariable analyses evaluating all metabolites jointly. Eleven metabolites were associated with breast cancer risk (q-value < 0.2). Seven metabolites remained associated after adjustment for established risk factors (p-value < 0.05) and were selected by at least one multivariable modeling approach: higher levels of 2-aminohippuric acid, kynurenic acid, piperine (all three with q-value < 0.2), DMGV and phenylacetylglutamine were associated with lower breast cancer risk (e.g., piperine: ORadjusted (95%CI) = 0.84 (0.77–0.92)) while higher levels of creatine and C40:7 phosphatidylethanolamine (PE) plasmalogen were associated with increased breast cancer risk (e.g., C40:7 PE plasmalogen: ORadjusted (95%CI) = 1.11 (1.01–1.22)). Five amino acids and amino acid-related metabolites (2-aminohippuric acid, DMGV, kynurenic acid, phenylacetylglutamine, and piperine) were inversely associated, while one amino acid and a phospholipid (creatine and C40:7 PE plasmalogen) were positively associated with breast cancer risk among predominately premenopausal women, independent of established breast cancer risk factors.Oana A. ZeleznikRaji BalasubramanianYibai ZhaoLisa FruehSarah JeanfavreJulian Avila-PachecoClary B. ClishShelley S. TworogerA. Heather EliassenNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Oana A. Zeleznik Raji Balasubramanian Yibai Zhao Lisa Frueh Sarah Jeanfavre Julian Avila-Pacheco Clary B. Clish Shelley S. Tworoger A. Heather Eliassen Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women
description	Abstract Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among predominantly premenopausal women of the Nurses’ Health Study II using conditional logistic regression (1057 cases, 1057 controls) and multivariable analyses evaluating all metabolites jointly. Eleven metabolites were associated with breast cancer risk (q-value < 0.2). Seven metabolites remained associated after adjustment for established risk factors (p-value < 0.05) and were selected by at least one multivariable modeling approach: higher levels of 2-aminohippuric acid, kynurenic acid, piperine (all three with q-value < 0.2), DMGV and phenylacetylglutamine were associated with lower breast cancer risk (e.g., piperine: ORadjusted (95%CI) = 0.84 (0.77–0.92)) while higher levels of creatine and C40:7 phosphatidylethanolamine (PE) plasmalogen were associated with increased breast cancer risk (e.g., C40:7 PE plasmalogen: ORadjusted (95%CI) = 1.11 (1.01–1.22)). Five amino acids and amino acid-related metabolites (2-aminohippuric acid, DMGV, kynurenic acid, phenylacetylglutamine, and piperine) were inversely associated, while one amino acid and a phospholipid (creatine and C40:7 PE plasmalogen) were positively associated with breast cancer risk among predominately premenopausal women, independent of established breast cancer risk factors.
format	article
author	Oana A. Zeleznik Raji Balasubramanian Yibai Zhao Lisa Frueh Sarah Jeanfavre Julian Avila-Pacheco Clary B. Clish Shelley S. Tworoger A. Heather Eliassen
author_facet	Oana A. Zeleznik Raji Balasubramanian Yibai Zhao Lisa Frueh Sarah Jeanfavre Julian Avila-Pacheco Clary B. Clish Shelley S. Tworoger A. Heather Eliassen
author_sort	Oana A. Zeleznik
title	Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women
title_short	Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women
title_full	Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women
title_fullStr	Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women
title_full_unstemmed	Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women
title_sort	circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/364911554b85499280a193b48fdf7611
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Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women

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