DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes

BRG1 and BRM are central components of the BAF (mSWI/SNF) chromatin remodelling complex, which is critical for regulation of chromatin structure. Here, the authors provide evidence that both the BRG1 and hBRM bromodomains have DNA-binding activity and bind to both DNA and H3K14ac simultaneously.

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Autores principales:	Emma A. Morrison, Julio C. Sanchez, Jehnna L. Ronan, Daniel P. Farrell, Katayoun Varzavand, Jenna K. Johnson, Brian X. Gu, Gerald R. Crabtree, Catherine A. Musselman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3649bcbbddde4952a8a4555506942341
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spelling	oai:doaj.org-article:3649bcbbddde4952a8a45555069423412021-12-02T14:42:09ZDNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes10.1038/ncomms160802041-1723https://doaj.org/article/3649bcbbddde4952a8a45555069423412017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16080https://doaj.org/toc/2041-1723BRG1 and BRM are central components of the BAF (mSWI/SNF) chromatin remodelling complex, which is critical for regulation of chromatin structure. Here, the authors provide evidence that both the BRG1 and hBRM bromodomains have DNA-binding activity and bind to both DNA and H3K14ac simultaneously.Emma A. MorrisonJulio C. SanchezJehnna L. RonanDaniel P. FarrellKatayoun VarzavandJenna K. JohnsonBrian X. GuGerald R. CrabtreeCatherine A. MusselmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emma A. Morrison Julio C. Sanchez Jehnna L. Ronan Daniel P. Farrell Katayoun Varzavand Jenna K. Johnson Brian X. Gu Gerald R. Crabtree Catherine A. Musselman DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes
description	BRG1 and BRM are central components of the BAF (mSWI/SNF) chromatin remodelling complex, which is critical for regulation of chromatin structure. Here, the authors provide evidence that both the BRG1 and hBRM bromodomains have DNA-binding activity and bind to both DNA and H3K14ac simultaneously.
format	article
author	Emma A. Morrison Julio C. Sanchez Jehnna L. Ronan Daniel P. Farrell Katayoun Varzavand Jenna K. Johnson Brian X. Gu Gerald R. Crabtree Catherine A. Musselman
author_facet	Emma A. Morrison Julio C. Sanchez Jehnna L. Ronan Daniel P. Farrell Katayoun Varzavand Jenna K. Johnson Brian X. Gu Gerald R. Crabtree Catherine A. Musselman
author_sort	Emma A. Morrison
title	DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes
title_short	DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes
title_full	DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes
title_fullStr	DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes
title_full_unstemmed	DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes
title_sort	dna binding drives the association of brg1/hbrm bromodomains with nucleosomes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3649bcbbddde4952a8a4555506942341
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DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes

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