Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers

Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers

BRCA-deficient breast cancer is characterised by homologous recombination deficiency. Here, the authors show that hypermethylated BRCA1 phenotypically copies mutated BRCA1 in triple negative breast cancers.

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Autores principales: Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/364ce59486504bf6a831a413fa23b595
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spelling oai:doaj.org-article:364ce59486504bf6a831a413fa23b5952021-12-02T16:14:05ZComprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers10.1038/s41467-020-17537-22041-1723https://doaj.org/article/364ce59486504bf6a831a413fa23b5952020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17537-2https://doaj.org/toc/2041-1723BRCA-deficient breast cancer is characterised by homologous recombination deficiency. Here, the authors show that hypermethylated BRCA1 phenotypically copies mutated BRCA1 in triple negative breast cancers.Dominik GlodzikAna BoschJohan HartmanMattias AineJohan Vallon-ChristerssonChristel ReuterswärdAnna KarlssonShamik MitraEmma NiméusKarolina HolmJari HäkkinenCecilia HegardtLao H. SaalChrister LarssonMartin MalmbergLisa RydénAnna EhingerNiklas LomanAnders KvistHans EhrencronaSerena Nik-ZainalÅke BorgJohan StaafNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dominik Glodzik
Ana Bosch
Johan Hartman
Mattias Aine
Johan Vallon-Christersson
Christel Reuterswärd
Anna Karlsson
Shamik Mitra
Emma Niméus
Karolina Holm
Jari Häkkinen
Cecilia Hegardt
Lao H. Saal
Christer Larsson
Martin Malmberg
Lisa Rydén
Anna Ehinger
Niklas Loman
Anders Kvist
Hans Ehrencrona
Serena Nik-Zainal
Åke Borg
Johan Staaf
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
description BRCA-deficient breast cancer is characterised by homologous recombination deficiency. Here, the authors show that hypermethylated BRCA1 phenotypically copies mutated BRCA1 in triple negative breast cancers.
format article
author Dominik Glodzik
Ana Bosch
Johan Hartman
Mattias Aine
Johan Vallon-Christersson
Christel Reuterswärd
Anna Karlsson
Shamik Mitra
Emma Niméus
Karolina Holm
Jari Häkkinen
Cecilia Hegardt
Lao H. Saal
Christer Larsson
Martin Malmberg
Lisa Rydén
Anna Ehinger
Niklas Loman
Anders Kvist
Hans Ehrencrona
Serena Nik-Zainal
Åke Borg
Johan Staaf
author_facet Dominik Glodzik
Ana Bosch
Johan Hartman
Mattias Aine
Johan Vallon-Christersson
Christel Reuterswärd
Anna Karlsson
Shamik Mitra
Emma Niméus
Karolina Holm
Jari Häkkinen
Cecilia Hegardt
Lao H. Saal
Christer Larsson
Martin Malmberg
Lisa Rydén
Anna Ehinger
Niklas Loman
Anders Kvist
Hans Ehrencrona
Serena Nik-Zainal
Åke Borg
Johan Staaf
author_sort Dominik Glodzik
title Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
title_short Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
title_full Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
title_fullStr Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
title_full_unstemmed Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
title_sort comprehensive molecular comparison of brca1 hypermethylated and brca1 mutated triple negative breast cancers
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/364ce59486504bf6a831a413fa23b595
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