Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of diversification, and guiding the discovery of poly...

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Autores principales:	Eric J. N. Helfrich, Reiko Ueoka, Marc G. Chevrette, Franziska Hemmerling, Xiaowen Lu, Stefan Leopold-Messer, Hannah A. Minas, Adrien Y. Burch, Steven E. Lindow, Jörn Piel, Marnix H. Medema
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/364e7f915c97493a91491df3c9ed6014
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spelling	oai:doaj.org-article:364e7f915c97493a91491df3c9ed60142021-12-02T15:53:25ZEvolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria10.1038/s41467-021-21163-x2041-1723https://doaj.org/article/364e7f915c97493a91491df3c9ed60142021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21163-xhttps://doaj.org/toc/2041-1723Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of diversification, and guiding the discovery of polyketides.Eric J. N. HelfrichReiko UeokaMarc G. ChevretteFranziska HemmerlingXiaowen LuStefan Leopold-MesserHannah A. MinasAdrien Y. BurchSteven E. LindowJörn PielMarnix H. MedemaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eric J. N. Helfrich Reiko Ueoka Marc G. Chevrette Franziska Hemmerling Xiaowen Lu Stefan Leopold-Messer Hannah A. Minas Adrien Y. Burch Steven E. Lindow Jörn Piel Marnix H. Medema Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria
description	Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of diversification, and guiding the discovery of polyketides.
format	article
author	Eric J. N. Helfrich Reiko Ueoka Marc G. Chevrette Franziska Hemmerling Xiaowen Lu Stefan Leopold-Messer Hannah A. Minas Adrien Y. Burch Steven E. Lindow Jörn Piel Marnix H. Medema
author_facet	Eric J. N. Helfrich Reiko Ueoka Marc G. Chevrette Franziska Hemmerling Xiaowen Lu Stefan Leopold-Messer Hannah A. Minas Adrien Y. Burch Steven E. Lindow Jörn Piel Marnix H. Medema
author_sort	Eric J. N. Helfrich
title	Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria
title_short	Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria
title_full	Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria
title_fullStr	Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria
title_full_unstemmed	Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria
title_sort	evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/364e7f915c97493a91491df3c9ed6014
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Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria

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