Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector.
Direct cellular reprogramming is a powerful new tool for regenerative medicine. In efforts to understand and treat Parkinson's Disease (PD), which is marked by the degeneration of dopaminergic neurons in the midbrain, direct reprogramming provides a valuable new source of these cells. Astrocyte...
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Auteurs principaux: | , , , , , |
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Format: | article |
Langue: | EN |
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Public Library of Science (PLoS)
2011
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Accès en ligne: | https://doaj.org/article/364f29015cae470780f9ac0d200fe2db |
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