Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib

Richard Quek1, Suzanne George21Visiting Fellow, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; 2Clinical Director, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USAAbstract: In the last decade a tremendous amount has been learne...

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Autores principales:	Richard Quek, Suzanne George
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/36531c7ae35848f485ca0f49aff90e57
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spelling	oai:doaj.org-article:36531c7ae35848f485ca0f49aff90e572021-12-02T05:04:41ZUpdate on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib1177-54751177-5491https://doaj.org/article/36531c7ae35848f485ca0f49aff90e572010-02-01T00:00:00Zhttp://www.dovepress.com/update-on-the-treatment-of-gastrointestinal-stromal-tumors-gists-role--a3939https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Richard Quek1, Suzanne George21Visiting Fellow, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; 2Clinical Director, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USAAbstract: In the last decade a tremendous amount has been learned about the biology and treatment of gastrointestinal stromal tumor (GIST). Imatinib mesylate has revolutionized the treatment of metastatic GIST. In addition, the role of imatinib in localized GIST has gained much interest and may improve patient outcomes. Additionally, research efforts aimed at understanding the biology and the molecular heterogeneity of GIST both at initial presentation and at the time of resistance to imatinib, has helped guide rational approaches to treatment as well as future efforts aimed at treating imatinib-resistant GIST.Keywords: gastrointestinal stromal tumors, GIST, review, imatinib, tyrosine kinase inhibitor, TKI Richard QuekSuzanne GeorgeDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 19-31 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Richard Quek Suzanne George Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib
description	Richard Quek1, Suzanne George21Visiting Fellow, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; 2Clinical Director, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USAAbstract: In the last decade a tremendous amount has been learned about the biology and treatment of gastrointestinal stromal tumor (GIST). Imatinib mesylate has revolutionized the treatment of metastatic GIST. In addition, the role of imatinib in localized GIST has gained much interest and may improve patient outcomes. Additionally, research efforts aimed at understanding the biology and the molecular heterogeneity of GIST both at initial presentation and at the time of resistance to imatinib, has helped guide rational approaches to treatment as well as future efforts aimed at treating imatinib-resistant GIST.Keywords: gastrointestinal stromal tumors, GIST, review, imatinib, tyrosine kinase inhibitor, TKI
format	article
author	Richard Quek Suzanne George
author_facet	Richard Quek Suzanne George
author_sort	Richard Quek
title	Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib
title_short	Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib
title_full	Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib
title_fullStr	Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib
title_full_unstemmed	Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib
title_sort	update on the treatment of gastrointestinal stromal tumors (gists): role of imatinib
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/36531c7ae35848f485ca0f49aff90e57
work_keys_str_mv	AT richardquek updateonthetreatmentofgastrointestinalstromaltumorsgistsroleofimatinib AT suzannegeorge updateonthetreatmentofgastrointestinalstromaltumorsgistsroleofimatinib
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Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib

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