Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman

Abstract Background Multiple sclerosis (MS) is an autoimmune disease that attacks the central nervous system, with optic neuritis (ON) being a common early manifestation. Retinal nerve fiber layer (RNFL) thickness may be a biomarker of neuroaxonal damage in MS patients. We sought to evaluate changes...

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Autores principales:	Abdullah S. Al-Mujaini, Maiysa S. Al-Mujaini, Buthaina I. Sabt
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Optic neuritis Multiple sclerosis Retinal nerve Fiber layer Optical coherence tomography Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/365461352c0c45c48b5370816039b707
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spelling	oai:doaj.org-article:365461352c0c45c48b5370816039b7072021-11-14T12:44:43ZRetinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman10.1186/s12886-021-02158-01471-2415https://doaj.org/article/365461352c0c45c48b5370816039b7072021-11-01T00:00:00Zhttps://doi.org/10.1186/s12886-021-02158-0https://doaj.org/toc/1471-2415Abstract Background Multiple sclerosis (MS) is an autoimmune disease that attacks the central nervous system, with optic neuritis (ON) being a common early manifestation. Retinal nerve fiber layer (RNFL) thickness may be a biomarker of neuroaxonal damage in MS patients. We sought to evaluate changes in RNFL thickness over 4 years in Omani MS patients with or without ON in comparison to a healthy control group. Methods This retrospective case-control study involved 27 MS patients and 25 healthy controls. Optical coherence tomography was performed upon first diagnosis and at a four-year follow-up. Differences in mean RNFL thickness were calculated. Results A total of 51 eyes from the MS group and 50 eyes from the control group were evaluated. There was a significant reduction in mean RNFL thickness among MS patients with ON at follow-up (81.21 versus 72.14 μm; P = .003), whereas no significant RNFL thinning was observed among MS patients without ON. However, there was a significant reduction in RNFL thickness among MS patients compared to healthy controls (76.79 versus 93.72 μm; P = .009), regardless of ON presence/absence. Conclusions Axonal damage was seen in the optic nerves of Omani MS patients. Moreover, there was a significant reduction in RNFL thickness among MS patients with ON as the disease progressed; however, while there was evidence of RNFL thinning in MS patients without ON, this difference lacked statistical significance. Evaluation of RNFL thickness may represent a useful biomarker for monitoring disease progression in MS and its association with ON.Abdullah S. Al-MujainiMaiysa S. Al-MujainiButhaina I. SabtBMCarticleOptic neuritisMultiple sclerosisRetinal nerve Fiber layerOptical coherence tomographyOphthalmologyRE1-994ENBMC Ophthalmology, Vol 21, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Optic neuritis Multiple sclerosis Retinal nerve Fiber layer Optical coherence tomography Ophthalmology RE1-994
spellingShingle	Optic neuritis Multiple sclerosis Retinal nerve Fiber layer Optical coherence tomography Ophthalmology RE1-994 Abdullah S. Al-Mujaini Maiysa S. Al-Mujaini Buthaina I. Sabt Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman
description	Abstract Background Multiple sclerosis (MS) is an autoimmune disease that attacks the central nervous system, with optic neuritis (ON) being a common early manifestation. Retinal nerve fiber layer (RNFL) thickness may be a biomarker of neuroaxonal damage in MS patients. We sought to evaluate changes in RNFL thickness over 4 years in Omani MS patients with or without ON in comparison to a healthy control group. Methods This retrospective case-control study involved 27 MS patients and 25 healthy controls. Optical coherence tomography was performed upon first diagnosis and at a four-year follow-up. Differences in mean RNFL thickness were calculated. Results A total of 51 eyes from the MS group and 50 eyes from the control group were evaluated. There was a significant reduction in mean RNFL thickness among MS patients with ON at follow-up (81.21 versus 72.14 μm; P = .003), whereas no significant RNFL thinning was observed among MS patients without ON. However, there was a significant reduction in RNFL thickness among MS patients compared to healthy controls (76.79 versus 93.72 μm; P = .009), regardless of ON presence/absence. Conclusions Axonal damage was seen in the optic nerves of Omani MS patients. Moreover, there was a significant reduction in RNFL thickness among MS patients with ON as the disease progressed; however, while there was evidence of RNFL thinning in MS patients without ON, this difference lacked statistical significance. Evaluation of RNFL thickness may represent a useful biomarker for monitoring disease progression in MS and its association with ON.
format	article
author	Abdullah S. Al-Mujaini Maiysa S. Al-Mujaini Buthaina I. Sabt
author_facet	Abdullah S. Al-Mujaini Maiysa S. Al-Mujaini Buthaina I. Sabt
author_sort	Abdullah S. Al-Mujaini
title	Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman
title_short	Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman
title_full	Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman
title_fullStr	Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman
title_full_unstemmed	Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman
title_sort	retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from oman
publisher	BMC
publishDate	2021
url	https://doaj.org/article/365461352c0c45c48b5370816039b707
work_keys_str_mv	AT abdullahsalmujaini retinalnervefiberlayerthicknessinmultiplesclerosiswithandwithoutopticneuritisafouryearfollowupstudyfromoman AT maiysasalmujaini retinalnervefiberlayerthicknessinmultiplesclerosiswithandwithoutopticneuritisafouryearfollowupstudyfromoman AT buthainaisabt retinalnervefiberlayerthicknessinmultiplesclerosiswithandwithoutopticneuritisafouryearfollowupstudyfromoman
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Retinal nerve fiber layer thickness in multiple sclerosis with and without optic neuritis: a four-year follow-up study from Oman

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