Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation

Yu-Cheng Cheng,1 Yu-Hsuan Li,1,2 Chiann-Yi Hsu,3 I-Te Lee1,4– 6 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 2Graduate Institute of Data Science, Taipei Medical University, Taipei, Taiwan; 3Biostatistics T...

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Autores principales:	Cheng YC, Li YH, Hsu CY, Lee IT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	ca19-9 cea diabetes prediabetes tumor marker Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3654ce724c834c0fb8db9a2d67a05709
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spelling	oai:doaj.org-article:3654ce724c834c0fb8db9a2d67a057092021-12-02T09:33:43ZSynergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation1178-7007https://doaj.org/article/3654ce724c834c0fb8db9a2d67a057092020-06-01T00:00:00Zhttps://www.dovepress.com/synergistic-association-of-carcinoembryonic-antigen-and-carbohydrate-a-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yu-Cheng Cheng,1 Yu-Hsuan Li,1,2 Chiann-Yi Hsu,3 I-Te Lee1,4– 6 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 2Graduate Institute of Data Science, Taipei Medical University, Taipei, Taiwan; 3Biostatistics Task Force of Taichung Veterans General Hospital, Taichung, Taiwan; 4School of Medicine, National Yang-Ming University, Taipei, Taiwan; 5School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 6College of Science, Tunghai University, Taichung, TaiwanCorrespondence: I-Te Lee Email itlee@vghtc.gov.twPurpose: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are tumor-associated antigens. An increased serum level of CEA and CA19-9 separately has been reported in diabetes. In this study, we examined the composite effect of elevated serum levels of both CEA and CA19-9 on subjects with type 2 diabetes and prediabetes.Patients and Methods: A total of 3568 adults who attended a health examination were enrolled into this cross-sectional study. Subjects were grouped into four groups according to the median serum CEA and CA19-9 levels.Results: Subjects with high CEA and high CA19-9 levels had the highest proportions of diabetes (43.9%) and prediabetes (33.04%). There was a statistically significant trend in the proportion of diabetes across the four groups (P < 0.001). Multivariable logistic regression analysis revealed higher risks of type 2 diabetes in subjects with high CEA and low CA19-9 levels (odds ratio [OR] = 2.10, 95% confidence interval [CI]: 1.39– 3.18, P < 0.001) and in those with high CA19-9 and low CEA levels (OR = 2.18, 95% CI: 1.42– 3.34, P < 0.001) than in those with low CEA and low CA19-9 levels; among these four groups, the highest risk of type 2 diabetes was observed in subjects with high CEA and high CA19-9 levels (OR = 2.65, 95% CI: 1.81– 3.88, P < 0.001). The risk of prediabetes was significantly higher only in subjects with high CEA and high CA19-9 levels compared to those with low CEA and low CA19-9 levels (OR = 1.32, 95% CI: 1.08– 1.61, P = 0.006).Conclusion: CEA and CA19-9 had a synergistic ability to increase the risk of type 2 diabetes and prediabetes.Keywords: CA19-9, CEA, diabetes, prediabetes, tumor markerCheng YCLi YHHsu CYLee ITDove Medical Pressarticleca19-9ceadiabetesprediabetestumor markerSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1933-1942 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ca19-9 cea diabetes prediabetes tumor marker Specialties of internal medicine RC581-951
spellingShingle	ca19-9 cea diabetes prediabetes tumor marker Specialties of internal medicine RC581-951 Cheng YC Li YH Hsu CY Lee IT Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation
description	Yu-Cheng Cheng,1 Yu-Hsuan Li,1,2 Chiann-Yi Hsu,3 I-Te Lee1,4– 6 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 2Graduate Institute of Data Science, Taipei Medical University, Taipei, Taiwan; 3Biostatistics Task Force of Taichung Veterans General Hospital, Taichung, Taiwan; 4School of Medicine, National Yang-Ming University, Taipei, Taiwan; 5School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 6College of Science, Tunghai University, Taichung, TaiwanCorrespondence: I-Te Lee Email itlee@vghtc.gov.twPurpose: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are tumor-associated antigens. An increased serum level of CEA and CA19-9 separately has been reported in diabetes. In this study, we examined the composite effect of elevated serum levels of both CEA and CA19-9 on subjects with type 2 diabetes and prediabetes.Patients and Methods: A total of 3568 adults who attended a health examination were enrolled into this cross-sectional study. Subjects were grouped into four groups according to the median serum CEA and CA19-9 levels.Results: Subjects with high CEA and high CA19-9 levels had the highest proportions of diabetes (43.9%) and prediabetes (33.04%). There was a statistically significant trend in the proportion of diabetes across the four groups (P < 0.001). Multivariable logistic regression analysis revealed higher risks of type 2 diabetes in subjects with high CEA and low CA19-9 levels (odds ratio [OR] = 2.10, 95% confidence interval [CI]: 1.39– 3.18, P < 0.001) and in those with high CA19-9 and low CEA levels (OR = 2.18, 95% CI: 1.42– 3.34, P < 0.001) than in those with low CEA and low CA19-9 levels; among these four groups, the highest risk of type 2 diabetes was observed in subjects with high CEA and high CA19-9 levels (OR = 2.65, 95% CI: 1.81– 3.88, P < 0.001). The risk of prediabetes was significantly higher only in subjects with high CEA and high CA19-9 levels compared to those with low CEA and low CA19-9 levels (OR = 1.32, 95% CI: 1.08– 1.61, P = 0.006).Conclusion: CEA and CA19-9 had a synergistic ability to increase the risk of type 2 diabetes and prediabetes.Keywords: CA19-9, CEA, diabetes, prediabetes, tumor marker
format	article
author	Cheng YC Li YH Hsu CY Lee IT
author_facet	Cheng YC Li YH Hsu CY Lee IT
author_sort	Cheng YC
title	Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation
title_short	Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation
title_full	Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation
title_fullStr	Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation
title_full_unstemmed	Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation
title_sort	synergistic association of carcinoembryonic antigen and carbohydrate antigen 19-9 on the risk of abnormal glucose regulation
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/3654ce724c834c0fb8db9a2d67a05709
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Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation

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