Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus

Adriana Elena Bulboacă,1 Paul Mihai Boarescu,1 Sorana D Bolboacă,2 Mihai Blidaru,1 Dana Feștilă,3 Gabriela Dogaru,4 Cristina Ariadna Nicula5 1Pathophysiology Department, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania; 2Department of Medical Informatics and Bios...

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Autores principales:	Bulboacă AE, Boarescu PM, Bolboacă SD, Blidaru M, Feștilă D, Dogaru G, Nicula CA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	diabetes mellitus inflammation curcumin cytokine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3655b7729793481da03194f047b4c123
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spelling	oai:doaj.org-article:3655b7729793481da03194f047b4c1232021-12-02T10:05:55ZComparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus1178-2013https://doaj.org/article/3655b7729793481da03194f047b4c1232019-11-01T00:00:00Zhttps://www.dovepress.com/comparative-effect-of-curcumin-versus-liposomal-curcumin-on-systemic-p-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Adriana Elena Bulboacă,1 Paul Mihai Boarescu,1 Sorana D Bolboacă,2 Mihai Blidaru,1 Dana Feștilă,3 Gabriela Dogaru,4 Cristina Ariadna Nicula5 1Pathophysiology Department, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania; 2Department of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine And Pharmacy, Cluj-Napoca, Romania; 3Department of Maxillofacial Surgery and Radiology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 4Department of Physical Medicine and Rehabilitation, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 5Department of Ophthalmology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, RomaniaCorrespondence: Sorana D BolboacăDepartment of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy, Louis Pasteur Str., No. 6, 400349, Cluj-Napoca, RomaniaTel +40 374 834 506Email sbolboaca@umfcluj.roPurpose: Anti-inflammatory proprieties of curcumin were proved to be useful in various diseases, including diabetes mellitus. The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-α (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1α, IL-1β, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.Materials and methods: Six groups of 7 rats were investigated regarding the effect of i.p. (intraperitoneal) administration of two concentrations of curcumin solution (CC1 and CC2) and two concentrations of liposomal curcumin (LCC1 and LCC2): group 1 – control group with i.p. administration of 1 mL saline solution, group 2 – i.p. STZ administration (60mg/kg bw, bw=body weight), group 3 – STZ+CC1 administration, group 4 – STZ+CC2 administration, group 5 – STZ+ LCC1 administration and group 6 – STZ+ LCC2 administration. The concentrations of curcumin formulas were 1 mg/0.1 kg bw for CC1 and LCC1 and 2 mg/0.1 kg bw for CC2 and LCC2, respectively. Serum levels of C-peptide (as an indicator of pancreatic function) and TNF-α, IL-6, IL-1α, IL-1β, MCP-1, and RANTES (as biomarkers for systemic inflammation) were assessed for each group.Results: The plasma level of C-peptide showed significant improvements when LCC was administrated, with better results for LCC2 when compared to LCC1 (P<0.003). LCC2 pretreatment proved to be more efficient in reducing the level of TNF-α (P<0.003) and RANTES (P<0.003) than CC2 pretreatment. Upon comparing LCC2 with LCC1 formulas, the differences were significant for TNF-α (P=0.004), IL-1β (P=0.022), and RANTES (P=0.003) levels.Conclusion: Liposomal curcumin in a dose of 2 mg/0.1 kg bw proved to have an optimum therapeutic effect as a pretreatment in DM induced by STZ. This result can constitute a base for clinical studies for curcumin efficiency as adjuvant therapy in type 1 DM.Keywords: diabetes mellitus, inflammation, curcumin, cytokineBulboacă AEBoarescu PMBolboacă SDBlidaru MFeștilă DDogaru GNicula CADove Medical Pressarticlediabetes mellitusinflammationcurcumincytokineMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 8961-8972 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus inflammation curcumin cytokine Medicine (General) R5-920
spellingShingle	diabetes mellitus inflammation curcumin cytokine Medicine (General) R5-920 Bulboacă AE Boarescu PM Bolboacă SD Blidaru M Feștilă D Dogaru G Nicula CA Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus
description	Adriana Elena Bulboacă,1 Paul Mihai Boarescu,1 Sorana D Bolboacă,2 Mihai Blidaru,1 Dana Feștilă,3 Gabriela Dogaru,4 Cristina Ariadna Nicula5 1Pathophysiology Department, Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania; 2Department of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine And Pharmacy, Cluj-Napoca, Romania; 3Department of Maxillofacial Surgery and Radiology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 4Department of Physical Medicine and Rehabilitation, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 5Department of Ophthalmology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, RomaniaCorrespondence: Sorana D BolboacăDepartment of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy, Louis Pasteur Str., No. 6, 400349, Cluj-Napoca, RomaniaTel +40 374 834 506Email sbolboaca@umfcluj.roPurpose: Anti-inflammatory proprieties of curcumin were proved to be useful in various diseases, including diabetes mellitus. The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-α (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1α, IL-1β, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.Materials and methods: Six groups of 7 rats were investigated regarding the effect of i.p. (intraperitoneal) administration of two concentrations of curcumin solution (CC1 and CC2) and two concentrations of liposomal curcumin (LCC1 and LCC2): group 1 – control group with i.p. administration of 1 mL saline solution, group 2 – i.p. STZ administration (60mg/kg bw, bw=body weight), group 3 – STZ+CC1 administration, group 4 – STZ+CC2 administration, group 5 – STZ+ LCC1 administration and group 6 – STZ+ LCC2 administration. The concentrations of curcumin formulas were 1 mg/0.1 kg bw for CC1 and LCC1 and 2 mg/0.1 kg bw for CC2 and LCC2, respectively. Serum levels of C-peptide (as an indicator of pancreatic function) and TNF-α, IL-6, IL-1α, IL-1β, MCP-1, and RANTES (as biomarkers for systemic inflammation) were assessed for each group.Results: The plasma level of C-peptide showed significant improvements when LCC was administrated, with better results for LCC2 when compared to LCC1 (P<0.003). LCC2 pretreatment proved to be more efficient in reducing the level of TNF-α (P<0.003) and RANTES (P<0.003) than CC2 pretreatment. Upon comparing LCC2 with LCC1 formulas, the differences were significant for TNF-α (P=0.004), IL-1β (P=0.022), and RANTES (P=0.003) levels.Conclusion: Liposomal curcumin in a dose of 2 mg/0.1 kg bw proved to have an optimum therapeutic effect as a pretreatment in DM induced by STZ. This result can constitute a base for clinical studies for curcumin efficiency as adjuvant therapy in type 1 DM.Keywords: diabetes mellitus, inflammation, curcumin, cytokine
format	article
author	Bulboacă AE Boarescu PM Bolboacă SD Blidaru M Feștilă D Dogaru G Nicula CA
author_facet	Bulboacă AE Boarescu PM Bolboacă SD Blidaru M Feștilă D Dogaru G Nicula CA
author_sort	Bulboacă AE
title	Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus
title_short	Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus
title_full	Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus
title_fullStr	Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus
title_full_unstemmed	Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus
title_sort	comparative effect of curcumin versus liposomal curcumin on systemic pro-inflammatory cytokines profile, mcp-1 and rantes in experimental diabetes mellitus
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3655b7729793481da03194f047b4c123
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Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus

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