Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men

Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men

Abstract Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential mechanism linking mLOY to disease risk in 206,353 UK males. Associations between mLOY, detected by genotypin...

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Autores principales: Shu-Hong Lin, Erikka Loftfield, Josh N. Sampson, Weiyin Zhou, Meredith Yeager, Neal D. Freedman, Stephen J. Chanock, Mitchell J. Machiela
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3657fd93f594486e8c3cc7036ed61d27
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