The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.

<h4>Background</h4>The relationship of cholesterol homeostasis and carotid intima-media thickness (cIMT) is unknown. To address this, we assessed markers of cholesterol homeostasis (serum plant sterols and cholesterol precursor concentrations as surrogate measures of cholesterol absorpti...

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Autores principales:	Oliver Weingärtner, Tobias Pinsdorf, Kyrill S Rogacev, Lutz Blömer, Yvonne Grenner, Stefan Gräber, Christof Ulrich, Matthias Girndt, Michael Böhm, Danilo Fliser, Ulrich Laufs, Dieter Lütjohann, Gunnar H Heine
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/365a458b1a4e4472834cb2386fc02952
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spelling	oai:doaj.org-article:365a458b1a4e4472834cb2386fc029522021-11-18T07:03:13ZThe relationships of markers of cholesterol homeostasis with carotid intima-media thickness.1932-620310.1371/journal.pone.0013467https://doaj.org/article/365a458b1a4e4472834cb2386fc029522010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20976107/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The relationship of cholesterol homeostasis and carotid intima-media thickness (cIMT) is unknown. To address this, we assessed markers of cholesterol homeostasis (serum plant sterols and cholesterol precursor concentrations as surrogate measures of cholesterol absorption and synthesis, respectively) and cIMT in a middle-aged, statin-naive population.<h4>Methods</h4>In this prospective study of primary prevention cIMT was measured by ultrasound in 583 hospital employees aged 25-60 years without prevalent cardiovascular disease or lipid-modifying medication. The serum concentrations of plant sterols (as markers of cholesterol absorption) were measured by gas-liquid chromatography. Lathosterol serum concentrations were quantitated to assess hepatic cholesterol synthesis.<h4>Results</h4>cIMT correlated positively with serum cholesterol (r = 0.22, P<0.0005) and lathosterol-to-cholesterol (r = 0.18, P<0.001). In contrast, plant sterols, as markers of cholesterol absorption, showed a weak negative correlation to cIMT measurements (r = -0.18; P<0.001 for campesterol-to-cholesterol). Stratifying subjects by serum sterol levels, we found that cIMT increased continuously over quintiles of serum cholesterol (P<0.0005) and was positively associated to serum lathosterol-to-cholesterol levels (P = 0.007), on the other hand, plant sterol levels showed a weak negative association to cIMT (P<0.001 for campesterol-to-cholesterol).<h4>Conclusions</h4>In this population without prevalent cardiovascular diseases or lipid-modifying medication, markers of increased endogenous cholesterol synthesis correlated positively with cIMT, while markers of cholesterol absorption showed a weakly negative correlation. These data suggest that not only total serum cholesterol levels but also differences in cholesterol homeostasis are associated with cIMT.Oliver WeingärtnerTobias PinsdorfKyrill S RogacevLutz BlömerYvonne GrennerStefan GräberChristof UlrichMatthias GirndtMichael BöhmDanilo FliserUlrich LaufsDieter LütjohannGunnar H HeinePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13467 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Oliver Weingärtner Tobias Pinsdorf Kyrill S Rogacev Lutz Blömer Yvonne Grenner Stefan Gräber Christof Ulrich Matthias Girndt Michael Böhm Danilo Fliser Ulrich Laufs Dieter Lütjohann Gunnar H Heine The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.
description	<h4>Background</h4>The relationship of cholesterol homeostasis and carotid intima-media thickness (cIMT) is unknown. To address this, we assessed markers of cholesterol homeostasis (serum plant sterols and cholesterol precursor concentrations as surrogate measures of cholesterol absorption and synthesis, respectively) and cIMT in a middle-aged, statin-naive population.<h4>Methods</h4>In this prospective study of primary prevention cIMT was measured by ultrasound in 583 hospital employees aged 25-60 years without prevalent cardiovascular disease or lipid-modifying medication. The serum concentrations of plant sterols (as markers of cholesterol absorption) were measured by gas-liquid chromatography. Lathosterol serum concentrations were quantitated to assess hepatic cholesterol synthesis.<h4>Results</h4>cIMT correlated positively with serum cholesterol (r = 0.22, P<0.0005) and lathosterol-to-cholesterol (r = 0.18, P<0.001). In contrast, plant sterols, as markers of cholesterol absorption, showed a weak negative correlation to cIMT measurements (r = -0.18; P<0.001 for campesterol-to-cholesterol). Stratifying subjects by serum sterol levels, we found that cIMT increased continuously over quintiles of serum cholesterol (P<0.0005) and was positively associated to serum lathosterol-to-cholesterol levels (P = 0.007), on the other hand, plant sterol levels showed a weak negative association to cIMT (P<0.001 for campesterol-to-cholesterol).<h4>Conclusions</h4>In this population without prevalent cardiovascular diseases or lipid-modifying medication, markers of increased endogenous cholesterol synthesis correlated positively with cIMT, while markers of cholesterol absorption showed a weakly negative correlation. These data suggest that not only total serum cholesterol levels but also differences in cholesterol homeostasis are associated with cIMT.
format	article
author	Oliver Weingärtner Tobias Pinsdorf Kyrill S Rogacev Lutz Blömer Yvonne Grenner Stefan Gräber Christof Ulrich Matthias Girndt Michael Böhm Danilo Fliser Ulrich Laufs Dieter Lütjohann Gunnar H Heine
author_facet	Oliver Weingärtner Tobias Pinsdorf Kyrill S Rogacev Lutz Blömer Yvonne Grenner Stefan Gräber Christof Ulrich Matthias Girndt Michael Böhm Danilo Fliser Ulrich Laufs Dieter Lütjohann Gunnar H Heine
author_sort	Oliver Weingärtner
title	The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.
title_short	The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.
title_full	The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.
title_fullStr	The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.
title_full_unstemmed	The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.
title_sort	relationships of markers of cholesterol homeostasis with carotid intima-media thickness.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/365a458b1a4e4472834cb2386fc02952
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The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.

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