Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system
How intracellular cAMP activate PKA is well-characterized, but PKA inactivation remains poorly understood. Here, Rinaldi et al. show that CHIP/HSP70 ubiquitinates the catalytic subunit of PKA, with implications for the human disease spinocerebellar ataxia 16, as patients often have CHIP mutations.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/365bbfa6102046adbb84b30bd59fe56c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:365bbfa6102046adbb84b30bd59fe56c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:365bbfa6102046adbb84b30bd59fe56c2021-12-02T16:58:02ZFeedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system10.1038/s41467-019-10037-y2041-1723https://doaj.org/article/365bbfa6102046adbb84b30bd59fe56c2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10037-yhttps://doaj.org/toc/2041-1723How intracellular cAMP activate PKA is well-characterized, but PKA inactivation remains poorly understood. Here, Rinaldi et al. show that CHIP/HSP70 ubiquitinates the catalytic subunit of PKA, with implications for the human disease spinocerebellar ataxia 16, as patients often have CHIP mutations.Laura RinaldiRossella Delle DonneBruno CatalanottiOmar Torres-QuesadaFlorian EnzlerFederica MoracaRobert NisticòFrancesco ChiusoSonia PiccininVerena BachmannHerbert H LindnerCorrado GarbiAntonella ScorzielloNicola Antonino RussoMatthis SynofzikUlrich StelzlLucio AnnunziatoEduard StefanAntonio FelicielloNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Laura Rinaldi Rossella Delle Donne Bruno Catalanotti Omar Torres-Quesada Florian Enzler Federica Moraca Robert Nisticò Francesco Chiuso Sonia Piccinin Verena Bachmann Herbert H Lindner Corrado Garbi Antonella Scorziello Nicola Antonino Russo Matthis Synofzik Ulrich Stelzl Lucio Annunziato Eduard Stefan Antonio Feliciello Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system |
| description |
How intracellular cAMP activate PKA is well-characterized, but PKA inactivation remains poorly understood. Here, Rinaldi et al. show that CHIP/HSP70 ubiquitinates the catalytic subunit of PKA, with implications for the human disease spinocerebellar ataxia 16, as patients often have CHIP mutations. |
| format |
article |
| author |
Laura Rinaldi Rossella Delle Donne Bruno Catalanotti Omar Torres-Quesada Florian Enzler Federica Moraca Robert Nisticò Francesco Chiuso Sonia Piccinin Verena Bachmann Herbert H Lindner Corrado Garbi Antonella Scorziello Nicola Antonino Russo Matthis Synofzik Ulrich Stelzl Lucio Annunziato Eduard Stefan Antonio Feliciello |
| author_facet |
Laura Rinaldi Rossella Delle Donne Bruno Catalanotti Omar Torres-Quesada Florian Enzler Federica Moraca Robert Nisticò Francesco Chiuso Sonia Piccinin Verena Bachmann Herbert H Lindner Corrado Garbi Antonella Scorziello Nicola Antonino Russo Matthis Synofzik Ulrich Stelzl Lucio Annunziato Eduard Stefan Antonio Feliciello |
| author_sort |
Laura Rinaldi |
| title |
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system |
| title_short |
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system |
| title_full |
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system |
| title_fullStr |
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system |
| title_full_unstemmed |
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system |
| title_sort |
feedback inhibition of camp effector signaling by a chaperone-assisted ubiquitin system |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/365bbfa6102046adbb84b30bd59fe56c |
| work_keys_str_mv |
AT laurarinaldi feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT rosselladelledonne feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT brunocatalanotti feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT omartorresquesada feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT florianenzler feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT federicamoraca feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT robertnistico feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT francescochiuso feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT soniapiccinin feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT verenabachmann feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT herberthlindner feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT corradogarbi feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT antonellascorziello feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT nicolaantoninorusso feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT matthissynofzik feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT ulrichstelzl feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT lucioannunziato feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT eduardstefan feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem AT antoniofeliciello feedbackinhibitionofcampeffectorsignalingbyachaperoneassistedubiquitinsystem |
| _version_ |
1718382378617929728 |