Modulatory interactions of resting-state brain functional connectivity in major depressive disorder

Zhe Tu,1–4,* Yuan Yuan Jia,2,5,* Tao Wang,2,3,* Hang Qu,2,3 Jun Xi Pan,2,3 Jie Jie,2,3 Xiao Yan Xu,2,3 Hai Yang Wang,2,3 Peng Xie1–3 1Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China; 2Department of Neurology, the First Affiliated Hospi...

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Autores principales:	Tu Z, Jia YY, Wang T, Qu H, Pan JX, Jie J, Xu XY, Wang HY, Xie P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Major depressive disorder physiophysiological modulatory effects resting-state networks Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/365ef751396547438510f5e280713fad
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spelling	oai:doaj.org-article:365ef751396547438510f5e280713fad2021-12-02T05:33:58ZModulatory interactions of resting-state brain functional connectivity in major depressive disorder1178-2021https://doaj.org/article/365ef751396547438510f5e280713fad2018-09-01T00:00:00Zhttps://www.dovepress.com/modulatory-interactions-of-resting-state-brain-functional-connectivity-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Zhe Tu,1–4,* Yuan Yuan Jia,2,5,* Tao Wang,2,3,* Hang Qu,2,3 Jun Xi Pan,2,3 Jie Jie,2,3 Xiao Yan Xu,2,3 Hai Yang Wang,2,3 Peng Xie1–3 1Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China; 2Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, China; 3Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, China; 4Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; 5The College of Medical Informatics, Chongqing Medical University, Chongqing, China *These authors contributed equally to this work Background: Major depressive disorder (MDD) is mediated by chronic dysregulation of complex neural circuits, particularly the specific neurotransmitters or other neural substrates. Recently, both increases and decreases in resting-state functional connectivity have been observed in patients with MDD. However, previous research has only assessed the functional connectivity within a specific network or some regions of interests, without considering the modulatory effects of the entire brain regions. To fill in the research gap, this study employed PPI (physiophysiological interaction) to investigate the functional connectivity in the entire brain regions. Apart from the traditional PPI used for cognitive research, current PPI analysis is more suitable for exploring the neural mechanism in MDD patients. Besides, this PPI method does not require a new cognitive estimation task and can assess the modulatory effects on different part of brain without prior setting of regions of interest. Methods: First, we recruited 76 outpatients with major depressive disorder, and conducted MRI scan to acquire structural and functional images. As referred to the previous study of resting-state networks, we identified eight well-defined intrinsic resting-state networks by using independent component analysis. Subsequently, we explored the regions that exhibited synchronous modulatory interactions within the network by executing PPI analysis. Results: Our findings indicated that the modulatory effects between healthy crowed and patient are different. By using PPI analysis in neuroimaging can help us to understand the mechanisms of neural disruptions in MDD patients. In addition, this study provides new insight into the complicated relationships between three or more regions of brain, as well as different brain networks functions in external and internal. Conclusion: Furthermore, the functional connectivity may deepen our knowledge regarding the complex brain functions in MDD patients and suggest a new multimodality treatment for MDD including targeted therapy and transcranial magnetic stimulation. Keywords: major depressive disorder, physiophysiological, modulatory effects, resting-state networksTu ZJia YYWang TQu HPan JXJie JXu XYWang HYXie PDove Medical PressarticleMajor depressive disorderphysiophysiologicalmodulatory effectsresting-state networksNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2461-2472 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Major depressive disorder physiophysiological modulatory effects resting-state networks Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Major depressive disorder physiophysiological modulatory effects resting-state networks Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tu Z Jia YY Wang T Qu H Pan JX Jie J Xu XY Wang HY Xie P Modulatory interactions of resting-state brain functional connectivity in major depressive disorder
description	Zhe Tu,1–4,* Yuan Yuan Jia,2,5,* Tao Wang,2,3,* Hang Qu,2,3 Jun Xi Pan,2,3 Jie Jie,2,3 Xiao Yan Xu,2,3 Hai Yang Wang,2,3 Peng Xie1–3 1Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China; 2Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, China; 3Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, China; 4Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; 5The College of Medical Informatics, Chongqing Medical University, Chongqing, China *These authors contributed equally to this work Background: Major depressive disorder (MDD) is mediated by chronic dysregulation of complex neural circuits, particularly the specific neurotransmitters or other neural substrates. Recently, both increases and decreases in resting-state functional connectivity have been observed in patients with MDD. However, previous research has only assessed the functional connectivity within a specific network or some regions of interests, without considering the modulatory effects of the entire brain regions. To fill in the research gap, this study employed PPI (physiophysiological interaction) to investigate the functional connectivity in the entire brain regions. Apart from the traditional PPI used for cognitive research, current PPI analysis is more suitable for exploring the neural mechanism in MDD patients. Besides, this PPI method does not require a new cognitive estimation task and can assess the modulatory effects on different part of brain without prior setting of regions of interest. Methods: First, we recruited 76 outpatients with major depressive disorder, and conducted MRI scan to acquire structural and functional images. As referred to the previous study of resting-state networks, we identified eight well-defined intrinsic resting-state networks by using independent component analysis. Subsequently, we explored the regions that exhibited synchronous modulatory interactions within the network by executing PPI analysis. Results: Our findings indicated that the modulatory effects between healthy crowed and patient are different. By using PPI analysis in neuroimaging can help us to understand the mechanisms of neural disruptions in MDD patients. In addition, this study provides new insight into the complicated relationships between three or more regions of brain, as well as different brain networks functions in external and internal. Conclusion: Furthermore, the functional connectivity may deepen our knowledge regarding the complex brain functions in MDD patients and suggest a new multimodality treatment for MDD including targeted therapy and transcranial magnetic stimulation. Keywords: major depressive disorder, physiophysiological, modulatory effects, resting-state networks
format	article
author	Tu Z Jia YY Wang T Qu H Pan JX Jie J Xu XY Wang HY Xie P
author_facet	Tu Z Jia YY Wang T Qu H Pan JX Jie J Xu XY Wang HY Xie P
author_sort	Tu Z
title	Modulatory interactions of resting-state brain functional connectivity in major depressive disorder
title_short	Modulatory interactions of resting-state brain functional connectivity in major depressive disorder
title_full	Modulatory interactions of resting-state brain functional connectivity in major depressive disorder
title_fullStr	Modulatory interactions of resting-state brain functional connectivity in major depressive disorder
title_full_unstemmed	Modulatory interactions of resting-state brain functional connectivity in major depressive disorder
title_sort	modulatory interactions of resting-state brain functional connectivity in major depressive disorder
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/365ef751396547438510f5e280713fad
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Modulatory interactions of resting-state brain functional connectivity in major depressive disorder

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