Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors

Targeted therapies for solid tumors in children, adolescents, and young adults (C-AYA) lag behind that of adult carcinomas. Here, the authors study the germline genomic signatures of 1,507 C-AYA patients with solid tumors and find pathogenic/likely pathogenic germline variants in diverse genes of wh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sara Akhavanfard, Roshan Padmanabhan, Lamis Yehia, Feixiong Cheng, Charis Eng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36633244b1ef47a0af16dac7729a6ae5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:36633244b1ef47a0af16dac7729a6ae5
record_format	dspace
spelling	oai:doaj.org-article:36633244b1ef47a0af16dac7729a6ae52021-12-02T17:32:43ZComprehensive germline genomic profiles of children, adolescents and young adults with solid tumors10.1038/s41467-020-16067-12041-1723https://doaj.org/article/36633244b1ef47a0af16dac7729a6ae52020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16067-1https://doaj.org/toc/2041-1723Targeted therapies for solid tumors in children, adolescents, and young adults (C-AYA) lag behind that of adult carcinomas. Here, the authors study the germline genomic signatures of 1,507 C-AYA patients with solid tumors and find pathogenic/likely pathogenic germline variants in diverse genes of which 1/3 of these alterations are druggable.Sara AkhavanfardRoshan PadmanabhanLamis YehiaFeixiong ChengCharis EngNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara Akhavanfard Roshan Padmanabhan Lamis Yehia Feixiong Cheng Charis Eng Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
description	Targeted therapies for solid tumors in children, adolescents, and young adults (C-AYA) lag behind that of adult carcinomas. Here, the authors study the germline genomic signatures of 1,507 C-AYA patients with solid tumors and find pathogenic/likely pathogenic germline variants in diverse genes of which 1/3 of these alterations are druggable.
format	article
author	Sara Akhavanfard Roshan Padmanabhan Lamis Yehia Feixiong Cheng Charis Eng
author_facet	Sara Akhavanfard Roshan Padmanabhan Lamis Yehia Feixiong Cheng Charis Eng
author_sort	Sara Akhavanfard
title	Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_short	Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_full	Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_fullStr	Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_full_unstemmed	Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
title_sort	comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/36633244b1ef47a0af16dac7729a6ae5
work_keys_str_mv	AT saraakhavanfard comprehensivegermlinegenomicprofilesofchildrenadolescentsandyoungadultswithsolidtumors AT roshanpadmanabhan comprehensivegermlinegenomicprofilesofchildrenadolescentsandyoungadultswithsolidtumors AT lamisyehia comprehensivegermlinegenomicprofilesofchildrenadolescentsandyoungadultswithsolidtumors AT feixiongcheng comprehensivegermlinegenomicprofilesofchildrenadolescentsandyoungadultswithsolidtumors AT chariseng comprehensivegermlinegenomicprofilesofchildrenadolescentsandyoungadultswithsolidtumors
_version_	1718380176777150464

Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors

Ejemplares similares