Informing Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data—Part II, Application

Using the methodology developed for integrated analysis and reporting of antimicrobial use (AMU) and antimicrobial resistance (AMR) data, farm-level surveillance data were synthesized and integrated to assess trends and explore potential AMU and AMR associations. Data from broiler chicken flocks (n...

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Autores principales:	Agnes Agunos, Sheryl P. Gow, Anne E. Deckert, David F. Léger
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	integration summarized reporting antimicrobial use antimicrobial resistance stewardship metric Medicine R
Acceso en línea:	https://doaj.org/article/3663941a168f47b288593e175ac3bd1c
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spelling	oai:doaj.org-article:3663941a168f47b288593e175ac3bd1c2021-11-25T18:38:40ZInforming Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data—Part II, Application10.3390/pathogens101114912076-0817https://doaj.org/article/3663941a168f47b288593e175ac3bd1c2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1491https://doaj.org/toc/2076-0817Using the methodology developed for integrated analysis and reporting of antimicrobial use (AMU) and antimicrobial resistance (AMR) data, farm-level surveillance data were synthesized and integrated to assess trends and explore potential AMU and AMR associations. Data from broiler chicken flocks (n = 656), grower–finisher pig herds (n = 462) and turkey flocks (n = 339) surveyed by the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) at the farm-level (2015–2019) were used. The analyses showed a reduction in mean flock/herd level number of defined daily doses using Canadian standards (nDDDvetCA) adjusted for kg animal biomass that coincided with the decline in % resistance in the three species. This was noted in most AMU-AMR pairs studied except for ciprofloxacin resistant <i>Campylobacter</i> where resistance continued to be detected (moderate to high levels) despite limited fluoroquinolone use. Noteworthy was the significantly negative association between the nDDDvetCA/kg animal biomass and susceptible <i>Escherichia coli</i> (multispecies data), an early indication that AMU stewardship actions are having an impact. However, an increase in the reporting of diseases in recent years was observed. This study highlighted the value of collecting high-resolution AMU surveillance data with animal health context at the farm-level to understand AMR trends, enable data integration and measure the impact of AMU stewardship actions.Agnes AgunosSheryl P. GowAnne E. DeckertDavid F. LégerMDPI AGarticleintegrationsummarized reportingantimicrobial useantimicrobial resistancestewardshipmetricMedicineRENPathogens, Vol 10, Iss 1491, p 1491 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	integration summarized reporting antimicrobial use antimicrobial resistance stewardship metric Medicine R
spellingShingle	integration summarized reporting antimicrobial use antimicrobial resistance stewardship metric Medicine R Agnes Agunos Sheryl P. Gow Anne E. Deckert David F. Léger Informing Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data—Part II, Application
description	Using the methodology developed for integrated analysis and reporting of antimicrobial use (AMU) and antimicrobial resistance (AMR) data, farm-level surveillance data were synthesized and integrated to assess trends and explore potential AMU and AMR associations. Data from broiler chicken flocks (n = 656), grower–finisher pig herds (n = 462) and turkey flocks (n = 339) surveyed by the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) at the farm-level (2015–2019) were used. The analyses showed a reduction in mean flock/herd level number of defined daily doses using Canadian standards (nDDDvetCA) adjusted for kg animal biomass that coincided with the decline in % resistance in the three species. This was noted in most AMU-AMR pairs studied except for ciprofloxacin resistant <i>Campylobacter</i> where resistance continued to be detected (moderate to high levels) despite limited fluoroquinolone use. Noteworthy was the significantly negative association between the nDDDvetCA/kg animal biomass and susceptible <i>Escherichia coli</i> (multispecies data), an early indication that AMU stewardship actions are having an impact. However, an increase in the reporting of diseases in recent years was observed. This study highlighted the value of collecting high-resolution AMU surveillance data with animal health context at the farm-level to understand AMR trends, enable data integration and measure the impact of AMU stewardship actions.
format	article
author	Agnes Agunos Sheryl P. Gow Anne E. Deckert David F. Léger
author_facet	Agnes Agunos Sheryl P. Gow Anne E. Deckert David F. Léger
author_sort	Agnes Agunos
title	Informing Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data—Part II, Application
title_short	Informing Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data—Part II, Application
title_full	Informing Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data—Part II, Application
title_fullStr	Informing Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data—Part II, Application
title_full_unstemmed	Informing Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data—Part II, Application
title_sort	informing stewardship measures in canadian food animal species through integrated reporting of antimicrobial use and antimicrobial resistance surveillance data—part ii, application
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3663941a168f47b288593e175ac3bd1c
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Informing Stewardship Measures in Canadian Food Animal Species through Integrated Reporting of Antimicrobial Use and Antimicrobial Resistance Surveillance Data—Part II, Application

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