Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.

Schizophrenia is a debilitating disorder affecting just under 1% of the population. While the symptoms of this disorder do not appear until late adolescence, pathological alterations likely occur earlier, during development in utero. While there is an increasing literature examining transcriptome al...

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Autores principales:	Jennifer J Donegan, Angela M Boley, Jeremy P Glenn, Melanie A Carless, Daniel J Lodge
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/366b584898644c75b6a035c42249e47f
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spelling	oai:doaj.org-article:366b584898644c75b6a035c42249e47f2021-12-02T20:11:29ZDevelopmental alterations in the transcriptome of three distinct rodent models of schizophrenia.1932-620310.1371/journal.pone.0232200https://doaj.org/article/366b584898644c75b6a035c42249e47f2020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0232200https://doaj.org/toc/1932-6203Schizophrenia is a debilitating disorder affecting just under 1% of the population. While the symptoms of this disorder do not appear until late adolescence, pathological alterations likely occur earlier, during development in utero. While there is an increasing literature examining transcriptome alterations in patients, it is not possible to examine the changes in gene expression that occur during development in humans that will develop schizophrenia. Here we utilize three distinct rodent developmental disruption models of schizophrenia to examine potential overlapping alterations in the transcriptome, with a specific focus on markers of interneuron development. Specifically, we administered either methylazoxymethanol acetate (MAM), Polyinosinic:polycytidylic acid (Poly I:C), or chronic protein malnutrition, on GD 17 and examined mRNA expression in the developing hippocampus of the offspring 18 hours later. Here, we report alterations in gene expression that may contribute to the pathophysiology of schizophrenia, including significant alterations in interneuron development and ribosome function.Jennifer J DoneganAngela M BoleyJeremy P GlennMelanie A CarlessDaniel J LodgePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 6, p e0232200 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer J Donegan Angela M Boley Jeremy P Glenn Melanie A Carless Daniel J Lodge Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.
description	Schizophrenia is a debilitating disorder affecting just under 1% of the population. While the symptoms of this disorder do not appear until late adolescence, pathological alterations likely occur earlier, during development in utero. While there is an increasing literature examining transcriptome alterations in patients, it is not possible to examine the changes in gene expression that occur during development in humans that will develop schizophrenia. Here we utilize three distinct rodent developmental disruption models of schizophrenia to examine potential overlapping alterations in the transcriptome, with a specific focus on markers of interneuron development. Specifically, we administered either methylazoxymethanol acetate (MAM), Polyinosinic:polycytidylic acid (Poly I:C), or chronic protein malnutrition, on GD 17 and examined mRNA expression in the developing hippocampus of the offspring 18 hours later. Here, we report alterations in gene expression that may contribute to the pathophysiology of schizophrenia, including significant alterations in interneuron development and ribosome function.
format	article
author	Jennifer J Donegan Angela M Boley Jeremy P Glenn Melanie A Carless Daniel J Lodge
author_facet	Jennifer J Donegan Angela M Boley Jeremy P Glenn Melanie A Carless Daniel J Lodge
author_sort	Jennifer J Donegan
title	Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.
title_short	Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.
title_full	Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.
title_fullStr	Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.
title_full_unstemmed	Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.
title_sort	developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/366b584898644c75b6a035c42249e47f
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Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.

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