Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.

<h4>Background</h4>Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated wit...

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Autores principales:	Qiuchen Jin, Fangjun Teng, Zhigang Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/366ba717a3254023a3620d6f6474ae75
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spelling	oai:doaj.org-article:366ba717a3254023a3620d6f6474ae752021-12-02T20:17:21ZAssociation between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.1932-620310.1371/journal.pone.0258138https://doaj.org/article/366ba717a3254023a3620d6f6474ae752021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258138https://doaj.org/toc/1932-6203<h4>Background</h4>Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose.<h4>Methods</h4>Eligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers.<h4>Results</h4>Twenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17-2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19-2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15-2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72-10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35-2.80, p<0.001) risk of peri-implant disease and 1.76-fold (95%CI 1.05-2.95, p = 0.032) risk of IF/IL than non-carriers.<h4>Conclusion</h4>Functional polymorphisms of IL-1α (C-889T), IL-1β (C+3954T, C-511T) and composite genotype of IL-1 can be used as predictive markers for peri-implant disease, whereas TNFα G-308A polymorphism was not associated with peri-implant disease.Qiuchen JinFangjun TengZhigang ChengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258138 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiuchen Jin Fangjun Teng Zhigang Cheng Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.
description	<h4>Background</h4>Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose.<h4>Methods</h4>Eligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers.<h4>Results</h4>Twenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17-2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19-2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15-2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72-10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35-2.80, p<0.001) risk of peri-implant disease and 1.76-fold (95%CI 1.05-2.95, p = 0.032) risk of IF/IL than non-carriers.<h4>Conclusion</h4>Functional polymorphisms of IL-1α (C-889T), IL-1β (C+3954T, C-511T) and composite genotype of IL-1 can be used as predictive markers for peri-implant disease, whereas TNFα G-308A polymorphism was not associated with peri-implant disease.
format	article
author	Qiuchen Jin Fangjun Teng Zhigang Cheng
author_facet	Qiuchen Jin Fangjun Teng Zhigang Cheng
author_sort	Qiuchen Jin
title	Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.
title_short	Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.
title_full	Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.
title_fullStr	Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.
title_full_unstemmed	Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.
title_sort	association between common polymorphisms in il-1 and tnfα and risk of peri-implant disease: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/366ba717a3254023a3620d6f6474ae75
work_keys_str_mv	AT qiuchenjin associationbetweencommonpolymorphismsinil1andtnfaandriskofperiimplantdiseaseametaanalysis AT fangjunteng associationbetweencommonpolymorphismsinil1andtnfaandriskofperiimplantdiseaseametaanalysis AT zhigangcheng associationbetweencommonpolymorphismsinil1andtnfaandriskofperiimplantdiseaseametaanalysis
_version_	1718374397942693888

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.

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