Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation

Pain and cognitive decline increase with age. In particular, there is a troubling relationship between dementia and pain, with some studies showing higher prevalence and inadequate treatment of pain in this population. Alzheimer’s disease (AD) is one of the most common causes of dementia in older ad...

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Autores principales:	Olivia Uddin, Keiko Arakawa, Charles Raver, Brendon Garagusi, Asaf Keller
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Pain Formalin Pain Amyloid 5XFAD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/366c8b5801fb4328959dfc8b56fe737f
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spelling	oai:doaj.org-article:366c8b5801fb4328959dfc8b56fe737f2021-11-14T04:34:45ZPatterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation2452-073X10.1016/j.ynpai.2021.100076https://doaj.org/article/366c8b5801fb4328959dfc8b56fe737f2021-08-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452073X21000179https://doaj.org/toc/2452-073XPain and cognitive decline increase with age. In particular, there is a troubling relationship between dementia and pain, with some studies showing higher prevalence and inadequate treatment of pain in this population. Alzheimer’s disease (AD) is one of the most common causes of dementia in older adults. Amyloid plaques are a hallmark of AD. The downstream processes these plaques promote are believed to affect neuronal and glial health and activity. There is a need to better understand how the neuropathological changes of AD shape neural activity and pain sensitivity. Here, we use the 5XFAD mouse model, in which dense amyloid accumulations occur at early ages, and in which previous studies reported signs of cognitive decline. We hypothesized that 5XFAD mice develop sensory and pain processing dysfunctions. Although amyloid burden was high throughout the brain, including in regions involved with sensory processing, we identified no functionally significant differences in reflexive or spontaneous signs of pain. Furthermore, expected signs of cognitive decline were modest; a finding consistent with variable results in the literature. These data suggest that models recapitulating other pathological features of Alzheimer’s disease might be better suited to studying differences in pain perception in this disease.Olivia UddinKeiko ArakawaCharles RaverBrendon GaragusiAsaf KellerElsevierarticlePainFormalin PainAmyloid5XFADNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeurobiology of Pain, Vol 10, Iss , Pp 100076- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pain Formalin Pain Amyloid 5XFAD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Pain Formalin Pain Amyloid 5XFAD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Olivia Uddin Keiko Arakawa Charles Raver Brendon Garagusi Asaf Keller Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation
description	Pain and cognitive decline increase with age. In particular, there is a troubling relationship between dementia and pain, with some studies showing higher prevalence and inadequate treatment of pain in this population. Alzheimer’s disease (AD) is one of the most common causes of dementia in older adults. Amyloid plaques are a hallmark of AD. The downstream processes these plaques promote are believed to affect neuronal and glial health and activity. There is a need to better understand how the neuropathological changes of AD shape neural activity and pain sensitivity. Here, we use the 5XFAD mouse model, in which dense amyloid accumulations occur at early ages, and in which previous studies reported signs of cognitive decline. We hypothesized that 5XFAD mice develop sensory and pain processing dysfunctions. Although amyloid burden was high throughout the brain, including in regions involved with sensory processing, we identified no functionally significant differences in reflexive or spontaneous signs of pain. Furthermore, expected signs of cognitive decline were modest; a finding consistent with variable results in the literature. These data suggest that models recapitulating other pathological features of Alzheimer’s disease might be better suited to studying differences in pain perception in this disease.
format	article
author	Olivia Uddin Keiko Arakawa Charles Raver Brendon Garagusi Asaf Keller
author_facet	Olivia Uddin Keiko Arakawa Charles Raver Brendon Garagusi Asaf Keller
author_sort	Olivia Uddin
title	Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation
title_short	Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation
title_full	Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation
title_fullStr	Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation
title_full_unstemmed	Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation
title_sort	patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/366c8b5801fb4328959dfc8b56fe737f
work_keys_str_mv	AT oliviauddin patternsofcognitivedeclineandsomatosensoryprocessinginamousemodelofamyloidaccumulation AT keikoarakawa patternsofcognitivedeclineandsomatosensoryprocessinginamousemodelofamyloidaccumulation AT charlesraver patternsofcognitivedeclineandsomatosensoryprocessinginamousemodelofamyloidaccumulation AT brendongaragusi patternsofcognitivedeclineandsomatosensoryprocessinginamousemodelofamyloidaccumulation AT asafkeller patternsofcognitivedeclineandsomatosensoryprocessinginamousemodelofamyloidaccumulation
_version_	1718429889916305408

Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation

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