Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart in...
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Nature Portfolio
2016
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oai:doaj.org-article:366e57a1bda54b80a00b5fe9ce11e6aa2021-12-02T16:49:41ZBioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction10.1038/ncomms133062041-1723https://doaj.org/article/366e57a1bda54b80a00b5fe9ce11e6aa2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13306https://doaj.org/toc/2041-1723Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart infarction mouse model.Shuting ZhaoZhaobin XuHai WangBenjamin E. ReeseLiubov V. GushchinaMeng JiangPranay AgarwalJiangsheng XuMingjun ZhangRulong ShenZhenguo LiuNoah WeislederXiaoming HeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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DOAJ |
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EN |
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Science Q |
spellingShingle |
Science Q Shuting Zhao Zhaobin Xu Hai Wang Benjamin E. Reese Liubov V. Gushchina Meng Jiang Pranay Agarwal Jiangsheng Xu Mingjun Zhang Rulong Shen Zhenguo Liu Noah Weisleder Xiaoming He Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction |
description |
Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart infarction mouse model. |
format |
article |
author |
Shuting Zhao Zhaobin Xu Hai Wang Benjamin E. Reese Liubov V. Gushchina Meng Jiang Pranay Agarwal Jiangsheng Xu Mingjun Zhang Rulong Shen Zhenguo Liu Noah Weisleder Xiaoming He |
author_facet |
Shuting Zhao Zhaobin Xu Hai Wang Benjamin E. Reese Liubov V. Gushchina Meng Jiang Pranay Agarwal Jiangsheng Xu Mingjun Zhang Rulong Shen Zhenguo Liu Noah Weisleder Xiaoming He |
author_sort |
Shuting Zhao |
title |
Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction |
title_short |
Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction |
title_full |
Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction |
title_fullStr |
Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction |
title_full_unstemmed |
Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction |
title_sort |
bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/366e57a1bda54b80a00b5fe9ce11e6aa |
work_keys_str_mv |
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