Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction

Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart in...

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Autores principales: Shuting Zhao, Zhaobin Xu, Hai Wang, Benjamin E. Reese, Liubov V. Gushchina, Meng Jiang, Pranay Agarwal, Jiangsheng Xu, Mingjun Zhang, Rulong Shen, Zhenguo Liu, Noah Weisleder, Xiaoming He
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/366e57a1bda54b80a00b5fe9ce11e6aa
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spelling oai:doaj.org-article:366e57a1bda54b80a00b5fe9ce11e6aa2021-12-02T16:49:41ZBioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction10.1038/ncomms133062041-1723https://doaj.org/article/366e57a1bda54b80a00b5fe9ce11e6aa2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13306https://doaj.org/toc/2041-1723Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart infarction mouse model.Shuting ZhaoZhaobin XuHai WangBenjamin E. ReeseLiubov V. GushchinaMeng JiangPranay AgarwalJiangsheng XuMingjun ZhangRulong ShenZhenguo LiuNoah WeislederXiaoming HeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shuting Zhao
Zhaobin Xu
Hai Wang
Benjamin E. Reese
Liubov V. Gushchina
Meng Jiang
Pranay Agarwal
Jiangsheng Xu
Mingjun Zhang
Rulong Shen
Zhenguo Liu
Noah Weisleder
Xiaoming He
Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
description Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart infarction mouse model.
format article
author Shuting Zhao
Zhaobin Xu
Hai Wang
Benjamin E. Reese
Liubov V. Gushchina
Meng Jiang
Pranay Agarwal
Jiangsheng Xu
Mingjun Zhang
Rulong Shen
Zhenguo Liu
Noah Weisleder
Xiaoming He
author_facet Shuting Zhao
Zhaobin Xu
Hai Wang
Benjamin E. Reese
Liubov V. Gushchina
Meng Jiang
Pranay Agarwal
Jiangsheng Xu
Mingjun Zhang
Rulong Shen
Zhenguo Liu
Noah Weisleder
Xiaoming He
author_sort Shuting Zhao
title Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_short Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_full Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_fullStr Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_full_unstemmed Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_sort bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/366e57a1bda54b80a00b5fe9ce11e6aa
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