Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction

Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart in...

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Main Authors:	Shuting Zhao, Zhaobin Xu, Hai Wang, Benjamin E. Reese, Liubov V. Gushchina, Meng Jiang, Pranay Agarwal, Jiangsheng Xu, Mingjun Zhang, Rulong Shen, Zhenguo Liu, Noah Weisleder, Xiaoming He
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/366e57a1bda54b80a00b5fe9ce11e6aa
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spelling	oai:doaj.org-article:366e57a1bda54b80a00b5fe9ce11e6aa2021-12-02T16:49:41ZBioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction10.1038/ncomms133062041-1723https://doaj.org/article/366e57a1bda54b80a00b5fe9ce11e6aa2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13306https://doaj.org/toc/2041-1723Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart infarction mouse model.Shuting ZhaoZhaobin XuHai WangBenjamin E. ReeseLiubov V. GushchinaMeng JiangPranay AgarwalJiangsheng XuMingjun ZhangRulong ShenZhenguo LiuNoah WeislederXiaoming HeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuting Zhao Zhaobin Xu Hai Wang Benjamin E. Reese Liubov V. Gushchina Meng Jiang Pranay Agarwal Jiangsheng Xu Mingjun Zhang Rulong Shen Zhenguo Liu Noah Weisleder Xiaoming He Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
description	Stem cell therapy of myocardial infarction is hampered by poor survival of injected cells. Here the authors develop injectable aggregates of stem cells differentiated to an early cardiac stage and encapsulated in a biodegradable micromatrix, and show their enhanced therapeutic efficacy in a heart infarction mouse model.
format	article
author	Shuting Zhao Zhaobin Xu Hai Wang Benjamin E. Reese Liubov V. Gushchina Meng Jiang Pranay Agarwal Jiangsheng Xu Mingjun Zhang Rulong Shen Zhenguo Liu Noah Weisleder Xiaoming He
author_facet	Shuting Zhao Zhaobin Xu Hai Wang Benjamin E. Reese Liubov V. Gushchina Meng Jiang Pranay Agarwal Jiangsheng Xu Mingjun Zhang Rulong Shen Zhenguo Liu Noah Weisleder Xiaoming He
author_sort	Shuting Zhao
title	Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_short	Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_full	Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_fullStr	Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_full_unstemmed	Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
title_sort	bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/366e57a1bda54b80a00b5fe9ce11e6aa
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Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction

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