Dietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract

Abstract Host diet is a major determinant of the composition and function of the intestinal microbiome. Less understood is the importance of diet on ingested strains with probiotic significance. We investigated the population dynamics of exogenous Lactobacillus plantarum and its interactions with in...

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Autores principales:	Xiaochen Yin, Bokyung Lee, Jose Zaragoza, Maria L. Marco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/367523a58c5a4ba6b87975aa65f63725
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spelling	oai:doaj.org-article:367523a58c5a4ba6b87975aa65f637252021-12-02T16:06:35ZDietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract10.1038/s41598-017-07428-w2045-2322https://doaj.org/article/367523a58c5a4ba6b87975aa65f637252017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07428-whttps://doaj.org/toc/2045-2322Abstract Host diet is a major determinant of the composition and function of the intestinal microbiome. Less understood is the importance of diet on ingested strains with probiotic significance. We investigated the population dynamics of exogenous Lactobacillus plantarum and its interactions with intestinal bacteria in mice undergoing switches between high-fat, high-sugar (HFHSD) and low-fat, plant-polysaccharide rich (LFPPD) diets. The survival and persistence of ingested L. plantarum WCFS1 was significantly improved during mouse consumption of HFHSD and was negatively associated with the numbers of indigenous Lactobacillus species. Diet also rapidly changed the composition of the indigenous microbiota, but with some taxa differentially affected between HFHSD periods. L. plantarum was not integrated into indigenous bacterial community networks according to co-occurrence patterns but still conferred distinct effects on bacterial species diversity and microbiota stability largely in a diet-dependent manner. Metagenome predictions supported the premise that L. plantarum dampens the effects of diet on the microbiome. This strain also consistently altered the predicted genetic content in the distal gut by enriching for genes encoding glyosyltransferases and bile salt hydrolases. Our findings demonstrate the interactions between ingested, transient probiotic bacteria and intestinal bacterial communities and how they can differ depending on host diet.Xiaochen YinBokyung LeeJose ZaragozaMaria L. MarcoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaochen Yin Bokyung Lee Jose Zaragoza Maria L. Marco Dietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract
description	Abstract Host diet is a major determinant of the composition and function of the intestinal microbiome. Less understood is the importance of diet on ingested strains with probiotic significance. We investigated the population dynamics of exogenous Lactobacillus plantarum and its interactions with intestinal bacteria in mice undergoing switches between high-fat, high-sugar (HFHSD) and low-fat, plant-polysaccharide rich (LFPPD) diets. The survival and persistence of ingested L. plantarum WCFS1 was significantly improved during mouse consumption of HFHSD and was negatively associated with the numbers of indigenous Lactobacillus species. Diet also rapidly changed the composition of the indigenous microbiota, but with some taxa differentially affected between HFHSD periods. L. plantarum was not integrated into indigenous bacterial community networks according to co-occurrence patterns but still conferred distinct effects on bacterial species diversity and microbiota stability largely in a diet-dependent manner. Metagenome predictions supported the premise that L. plantarum dampens the effects of diet on the microbiome. This strain also consistently altered the predicted genetic content in the distal gut by enriching for genes encoding glyosyltransferases and bile salt hydrolases. Our findings demonstrate the interactions between ingested, transient probiotic bacteria and intestinal bacterial communities and how they can differ depending on host diet.
format	article
author	Xiaochen Yin Bokyung Lee Jose Zaragoza Maria L. Marco
author_facet	Xiaochen Yin Bokyung Lee Jose Zaragoza Maria L. Marco
author_sort	Xiaochen Yin
title	Dietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract
title_short	Dietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract
title_full	Dietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract
title_fullStr	Dietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract
title_full_unstemmed	Dietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract
title_sort	dietary perturbations alter the ecological significance of ingested lactobacillus plantarum in the digestive tract
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/367523a58c5a4ba6b87975aa65f63725
work_keys_str_mv	AT xiaochenyin dietaryperturbationsaltertheecologicalsignificanceofingestedlactobacillusplantaruminthedigestivetract AT bokyunglee dietaryperturbationsaltertheecologicalsignificanceofingestedlactobacillusplantaruminthedigestivetract AT josezaragoza dietaryperturbationsaltertheecologicalsignificanceofingestedlactobacillusplantaruminthedigestivetract AT marialmarco dietaryperturbationsaltertheecologicalsignificanceofingestedlactobacillusplantaruminthedigestivetract
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Dietary perturbations alter the ecological significance of ingested Lactobacillus plantarum in the digestive tract

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