High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia

SOD-like activity of CeO2 nanoparticles (Ce NPs) is driven by Ce3+/Ce4+, high oxidative stress can oxidize Ce3+ to reduce the ratio of Ce3+/Ce4+, inactivating the SOD activity of Ce NPs. Herein, we found Au@Ce NPs, assembled by Au NPs and Ce NPs, exhibited high-performance of SOD mimetic enzyme acti...

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Autores principales:	Yuxiang Sun, Xin Liu, Lei Wang, Li Xu, Kunliang Liu, Lei Xu, Fangfang Shi, Yu Zhang, Ning Gu, Fei Xiong
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Superoxide dismutase Au nanoparticles CeO2 nanoparticles Reactive oxygen species Acute myeloid leukemia Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3679e350d6114dc68287f4824cc145e7
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spelling	oai:doaj.org-article:3679e350d6114dc68287f4824cc145e72021-11-26T04:36:42ZHigh-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia2452-199X10.1016/j.bioactmat.2021.08.012https://doaj.org/article/3679e350d6114dc68287f4824cc145e72022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003893https://doaj.org/toc/2452-199XSOD-like activity of CeO2 nanoparticles (Ce NPs) is driven by Ce3+/Ce4+, high oxidative stress can oxidize Ce3+ to reduce the ratio of Ce3+/Ce4+, inactivating the SOD activity of Ce NPs. Herein, we found Au@Ce NPs, assembled by Au NPs and Ce NPs, exhibited high-performance of SOD mimetic enzyme activity even upon the oxidation of H2O2. Ce NPs supported by nano-Au can acquire the electrons from Au NPs through the enhanced localized surface plasmon resonance (LSPR), maintaining the stability of Ce3+/Ce4+ and SOD-like activity. Meanwhile, Au@Ce NPs retained the peroxidase function and catalase function. As a result, Au@Ce NPs effectively scavenged O2•- and the derived ROS in AML cells, which are the important signaling source that drives AML cell proliferation and accelerates cell cycle progression. When HL-60 cells were treated by Au@Ce NPs, the removal of endogenous ROS signal significantly arrested cell cycle at G1 phase and suppressed the cell proliferation by blocking the mitogen-activated protein kinases (MAPKs) signaling and the Akt/Cyclin D1 cell cycle signaling. Importantly, this treatment strategy showed therapeutic effect for subcutaneous transplantation of AML model as well as a satisfactory result in diminishing the leukocyte infiltration of liver and spleen particularly. Thus, assembled Au@Ce NPs show the high-performance SOD-like activity, promising the potential in treating AML and regulating abnormal ROS in other diseases safely and efficiently.Yuxiang SunXin LiuLei WangLi XuKunliang LiuLei XuFangfang ShiYu ZhangNing GuFei XiongKeAi Communications Co., Ltd.articleSuperoxide dismutaseAu nanoparticlesCeO2 nanoparticlesReactive oxygen speciesAcute myeloid leukemiaMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 117-130 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Superoxide dismutase Au nanoparticles CeO2 nanoparticles Reactive oxygen species Acute myeloid leukemia Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Superoxide dismutase Au nanoparticles CeO2 nanoparticles Reactive oxygen species Acute myeloid leukemia Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Yuxiang Sun Xin Liu Lei Wang Li Xu Kunliang Liu Lei Xu Fangfang Shi Yu Zhang Ning Gu Fei Xiong High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia
description	SOD-like activity of CeO2 nanoparticles (Ce NPs) is driven by Ce3+/Ce4+, high oxidative stress can oxidize Ce3+ to reduce the ratio of Ce3+/Ce4+, inactivating the SOD activity of Ce NPs. Herein, we found Au@Ce NPs, assembled by Au NPs and Ce NPs, exhibited high-performance of SOD mimetic enzyme activity even upon the oxidation of H2O2. Ce NPs supported by nano-Au can acquire the electrons from Au NPs through the enhanced localized surface plasmon resonance (LSPR), maintaining the stability of Ce3+/Ce4+ and SOD-like activity. Meanwhile, Au@Ce NPs retained the peroxidase function and catalase function. As a result, Au@Ce NPs effectively scavenged O2•- and the derived ROS in AML cells, which are the important signaling source that drives AML cell proliferation and accelerates cell cycle progression. When HL-60 cells were treated by Au@Ce NPs, the removal of endogenous ROS signal significantly arrested cell cycle at G1 phase and suppressed the cell proliferation by blocking the mitogen-activated protein kinases (MAPKs) signaling and the Akt/Cyclin D1 cell cycle signaling. Importantly, this treatment strategy showed therapeutic effect for subcutaneous transplantation of AML model as well as a satisfactory result in diminishing the leukocyte infiltration of liver and spleen particularly. Thus, assembled Au@Ce NPs show the high-performance SOD-like activity, promising the potential in treating AML and regulating abnormal ROS in other diseases safely and efficiently.
format	article
author	Yuxiang Sun Xin Liu Lei Wang Li Xu Kunliang Liu Lei Xu Fangfang Shi Yu Zhang Ning Gu Fei Xiong
author_facet	Yuxiang Sun Xin Liu Lei Wang Li Xu Kunliang Liu Lei Xu Fangfang Shi Yu Zhang Ning Gu Fei Xiong
author_sort	Yuxiang Sun
title	High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia
title_short	High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia
title_full	High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia
title_fullStr	High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia
title_full_unstemmed	High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia
title_sort	high-performance sod mimetic enzyme au@ce for arresting cell cycle and proliferation of acute myeloid leukemia
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/3679e350d6114dc68287f4824cc145e7
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High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia

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