Tadalafil Modulates Intracerebroventricular Streptozotocin-Induced Cognition and Memory Impairment in the Young and Middle-Aged Rats

Background: Learning and memory may decline due to Alzheimer’s disease (AD) in older adults. A reduction in cyclic guanosine monophosphate concentration and an increase in phosphodiesterase activity have been reported in the process of aging. Althoughphosphodiesterase (PDE) type 5 inhibitor, Tadalaf...

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Autores principales:	Siamak Shahidi, Masoumeh Asadbegi, Nasrin Hashemi-Firouzi, Alireza Komaki, Minoo Mahmoodi
Formato:	article
Lenguaje:	EN
Publicado:	Tabriz University of Medical Sciences 2021
Materias:	aging cognition memory rat streptozotocin tadalafil Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/367a07e32fb547a58191f8f2152b75f7
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spelling	oai:doaj.org-article:367a07e32fb547a58191f8f2152b75f72021-11-29T05:52:36ZTadalafil Modulates Intracerebroventricular Streptozotocin-Induced Cognition and Memory Impairment in the Young and Middle-Aged Rats2383-288610.34172/PS.2021.8https://doaj.org/article/367a07e32fb547a58191f8f2152b75f72021-12-01T00:00:00Zhttps://ps.tbzmed.ac.ir/PDF/ps-27-511.pdfhttps://doaj.org/toc/2383-2886Background: Learning and memory may decline due to Alzheimer’s disease (AD) in older adults. A reduction in cyclic guanosine monophosphate concentration and an increase in phosphodiesterase activity have been reported in the process of aging. Althoughphosphodiesterase (PDE) type 5 inhibitor, Tadalafil is used to treat erectile dysfunction; PDE inhibitors possibly prevent cognition impairment in aging. This study was designed to investigate the effects of tadalafil on memory in middle-aged and young healthy and AD rats. Methods: Memory impairment was induced by intracerebroventricular (ICV) administration of streptozotocin (STZ; 3 mg/kg) in AD rats. Male Wistar rats (middle-aged and young) were distributed into six groups as follows: two control, two AD, and two AD+tadalafil (1 mg/kg)groups. Saline or tadalafil was administered once a day orally for 40 consecutive days. Animals were tested using novel object recognition (NOR), passive avoidance learning (PAL), and Morris water maze (MWM) tests. Results: Aged AD rats exhibited a significant impairment in cognition in the NOR test and impaired learning and memory in PAL and MWM tests compared with the control aged rats. Tadalafil treatment in aged AD rats significantly improved the discrimination index in the NORtest, decreased the time spent in the dark compartment in the PAL test, and increased time spent in the target quadrant in MWM tests compared with aged AD rats. In young AD rats, treatment with tadalafil significantly enhanced cognition, learning, and memory in the NOR, PAL, andMWM tests compared with young AD rats treated with saline. Conclusion: Tadalafil treatment in aged rats improves cognition and memory after STZ-induced(ICV) memory impairment. It can be concluded that chronic treatment with tadalafil is protective against cognitive, learning, and memory impairment in both young and aged subjects.Siamak ShahidiMasoumeh AsadbegiNasrin Hashemi-FirouziAlireza KomakiMinoo MahmoodiTabriz University of Medical SciencesarticleagingcognitionmemoryratstreptozotocintadalafilPharmacy and materia medicaRS1-441ENPharmaceutical Sciences, Vol 27, Iss 4, Pp 511-520 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging cognition memory rat streptozotocin tadalafil Pharmacy and materia medica RS1-441
spellingShingle	aging cognition memory rat streptozotocin tadalafil Pharmacy and materia medica RS1-441 Siamak Shahidi Masoumeh Asadbegi Nasrin Hashemi-Firouzi Alireza Komaki Minoo Mahmoodi Tadalafil Modulates Intracerebroventricular Streptozotocin-Induced Cognition and Memory Impairment in the Young and Middle-Aged Rats
description	Background: Learning and memory may decline due to Alzheimer’s disease (AD) in older adults. A reduction in cyclic guanosine monophosphate concentration and an increase in phosphodiesterase activity have been reported in the process of aging. Althoughphosphodiesterase (PDE) type 5 inhibitor, Tadalafil is used to treat erectile dysfunction; PDE inhibitors possibly prevent cognition impairment in aging. This study was designed to investigate the effects of tadalafil on memory in middle-aged and young healthy and AD rats. Methods: Memory impairment was induced by intracerebroventricular (ICV) administration of streptozotocin (STZ; 3 mg/kg) in AD rats. Male Wistar rats (middle-aged and young) were distributed into six groups as follows: two control, two AD, and two AD+tadalafil (1 mg/kg)groups. Saline or tadalafil was administered once a day orally for 40 consecutive days. Animals were tested using novel object recognition (NOR), passive avoidance learning (PAL), and Morris water maze (MWM) tests. Results: Aged AD rats exhibited a significant impairment in cognition in the NOR test and impaired learning and memory in PAL and MWM tests compared with the control aged rats. Tadalafil treatment in aged AD rats significantly improved the discrimination index in the NORtest, decreased the time spent in the dark compartment in the PAL test, and increased time spent in the target quadrant in MWM tests compared with aged AD rats. In young AD rats, treatment with tadalafil significantly enhanced cognition, learning, and memory in the NOR, PAL, andMWM tests compared with young AD rats treated with saline. Conclusion: Tadalafil treatment in aged rats improves cognition and memory after STZ-induced(ICV) memory impairment. It can be concluded that chronic treatment with tadalafil is protective against cognitive, learning, and memory impairment in both young and aged subjects.
format	article
author	Siamak Shahidi Masoumeh Asadbegi Nasrin Hashemi-Firouzi Alireza Komaki Minoo Mahmoodi
author_facet	Siamak Shahidi Masoumeh Asadbegi Nasrin Hashemi-Firouzi Alireza Komaki Minoo Mahmoodi
author_sort	Siamak Shahidi
title	Tadalafil Modulates Intracerebroventricular Streptozotocin-Induced Cognition and Memory Impairment in the Young and Middle-Aged Rats
title_short	Tadalafil Modulates Intracerebroventricular Streptozotocin-Induced Cognition and Memory Impairment in the Young and Middle-Aged Rats
title_full	Tadalafil Modulates Intracerebroventricular Streptozotocin-Induced Cognition and Memory Impairment in the Young and Middle-Aged Rats
title_fullStr	Tadalafil Modulates Intracerebroventricular Streptozotocin-Induced Cognition and Memory Impairment in the Young and Middle-Aged Rats
title_full_unstemmed	Tadalafil Modulates Intracerebroventricular Streptozotocin-Induced Cognition and Memory Impairment in the Young and Middle-Aged Rats
title_sort	tadalafil modulates intracerebroventricular streptozotocin-induced cognition and memory impairment in the young and middle-aged rats
publisher	Tabriz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/367a07e32fb547a58191f8f2152b75f7
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Tadalafil Modulates Intracerebroventricular Streptozotocin-Induced Cognition and Memory Impairment in the Young and Middle-Aged Rats

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