Peculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome

Acute respiratory distress syndrome (ARDS) was reproduced in nonlinear male rats by intratracheal instillation of 45—55 thousand, lysate rat neutrophils (method patented in RF); the control group was injected with saline solution. The animals were taken from the experiment at 1, 3 and 6 days, the ex...

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Autores principales:	E. V. Prutkina, A. V. Sepp, N. N. Tsybikov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	experimental distress syndrome matrix metalloproteinase-9 cells of the lungs Science Q
Acceso en línea:	https://doaj.org/article/367bc28aa87d46ab8fdf7054ead6b441
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spelling	oai:doaj.org-article:367bc28aa87d46ab8fdf7054ead6b4412021-11-23T06:14:26ZPeculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome2541-94202587-9596https://doaj.org/article/367bc28aa87d46ab8fdf7054ead6b4412013-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1417https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Acute respiratory distress syndrome (ARDS) was reproduced in nonlinear male rats by intratracheal instillation of 45—55 thousand, lysate rat neutrophils (method patented in RF); the control group was injected with saline solution. The animals were taken from the experiment at 1, 3 and 6 days, the expression of matrix metallopro-teinase-9 (MMP-9) by cells of the lungs was determined, by immunohistochemistry at each days. The expression of MMP-9 was found in neutrophils, macrophages, fibroblasts, endothelium and. type 2 alveolocytes in the both groups. In the control group the expression, of MMP-9 was found equally low in the all cells, except type 2 alveolocytes. It was decreased in type 2 alveolocytes on day 6. A significant increase in the expression of MMP-9 was found in neutrophils, macrophages, fibroblasts endothelium and type 2 alveolocytes in the exudative stage of ARDS. In the proliferative stage the expression of MMP-9 was high in all the cells, decreasing only in type 2 alveolocytes. In the fibrotic stage of expression of MMP-9 returned to the level of the control group in macrophages, type 2 alveolocytes, the endothelium; in neutrophils and fibroblasts it remained high.E. V. PrutkinaA. V. SeppN. N. TsybikovScientific Сentre for Family Health and Human Reproduction Problemsarticleexperimental distress syndromematrix metalloproteinase-9cells of the lungsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 1, Pp 121-124 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	experimental distress syndrome matrix metalloproteinase-9 cells of the lungs Science Q
spellingShingle	experimental distress syndrome matrix metalloproteinase-9 cells of the lungs Science Q E. V. Prutkina A. V. Sepp N. N. Tsybikov Peculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome
description	Acute respiratory distress syndrome (ARDS) was reproduced in nonlinear male rats by intratracheal instillation of 45—55 thousand, lysate rat neutrophils (method patented in RF); the control group was injected with saline solution. The animals were taken from the experiment at 1, 3 and 6 days, the expression of matrix metallopro-teinase-9 (MMP-9) by cells of the lungs was determined, by immunohistochemistry at each days. The expression of MMP-9 was found in neutrophils, macrophages, fibroblasts, endothelium and. type 2 alveolocytes in the both groups. In the control group the expression, of MMP-9 was found equally low in the all cells, except type 2 alveolocytes. It was decreased in type 2 alveolocytes on day 6. A significant increase in the expression of MMP-9 was found in neutrophils, macrophages, fibroblasts endothelium and type 2 alveolocytes in the exudative stage of ARDS. In the proliferative stage the expression of MMP-9 was high in all the cells, decreasing only in type 2 alveolocytes. In the fibrotic stage of expression of MMP-9 returned to the level of the control group in macrophages, type 2 alveolocytes, the endothelium; in neutrophils and fibroblasts it remained high.
format	article
author	E. V. Prutkina A. V. Sepp N. N. Tsybikov
author_facet	E. V. Prutkina A. V. Sepp N. N. Tsybikov
author_sort	E. V. Prutkina
title	Peculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome
title_short	Peculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome
title_full	Peculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome
title_fullStr	Peculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome
title_full_unstemmed	Peculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome
title_sort	peculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/367bc28aa87d46ab8fdf7054ead6b441
work_keys_str_mv	AT evprutkina peculiaritiesofsynthesisofmatrixmetalloproteinase9inthelungsduringexperimentaldevelopmentofdistresssyndrome AT avsepp peculiaritiesofsynthesisofmatrixmetalloproteinase9inthelungsduringexperimentaldevelopmentofdistresssyndrome AT nntsybikov peculiaritiesofsynthesisofmatrixmetalloproteinase9inthelungsduringexperimentaldevelopmentofdistresssyndrome
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Peculiarities of synthesis of matrix metalloproteinase-9 in the lungs during experimental development of distress syndrome

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