Potential role of phytochemicals in metabolic syndrome prevention and therapy

Francesco Francini-Pesenti,1 Paolo Spinella,1 Lorenzo A Calò2 1Department of Medicine (DIMED), Nutrition Unit, University of Padova-Azienda Ospedaliera, Padova, Italy; 2Department of Medicine (DIMED), Nephrology, Dialysis and Transplantation Unit, University of Padova-Azienda Ospedaliera,...

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Autores principales:	Francini-Pesenti F, Spinella P, Calò LA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Metabolic Syndrome bioactive substances nutrition cardiovascular risk Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/367d6fff8d23466a84ebe831d3f37b8e
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spelling	oai:doaj.org-article:367d6fff8d23466a84ebe831d3f37b8e2021-12-02T05:36:18ZPotential role of phytochemicals in metabolic syndrome prevention and therapy1178-7007https://doaj.org/article/367d6fff8d23466a84ebe831d3f37b8e2019-10-01T00:00:00Zhttps://www.dovepress.com/potential-role-of-phytochemicals-in-metabolic-syndrome-prevention-and--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Francesco Francini-Pesenti,1 Paolo Spinella,1 Lorenzo A Calò2 1Department of Medicine (DIMED), Nutrition Unit, University of Padova-Azienda Ospedaliera, Padova, Italy; 2Department of Medicine (DIMED), Nephrology, Dialysis and Transplantation Unit, University of Padova-Azienda Ospedaliera, Padova, ItalyCorrespondence: Lorenzo A Cal&#x00F2Department of Medicine, Nephrology, Dialysis and Transplantation Unit, University of Padova-Azienda Ospedaliera, Via Giustiniani 2, Padova 35128, ItalyTel +39 049 821 3071Fax +39 049 821 7921Email renzcalo@unipd.itAbstract: Metabolic syndrome (MetS) is a set of cardiovascular risk factors which severely increases the risk of type II diabetes, renal disease and cardiovascular disease. Over the last decades, the role of dietary bioactive substances in features of MetS has been extensively investigated. Due to their multiple properties, these plant-derived natural compounds have demonstrated to provide positive effects in obesity, diabetes, renal and in cardiovascular disease. Catechins of green tea and caffeine reduce body mass index and waist circumference. Catechins, anthocyanins and proanthocyanidins of cocoa reduce blood pressure and blood glucose. Curcumin and silymarin exert hepatoprotective effects. Monacolins of red yeast rice are effective cholesterol-lowering agents. However, inconsistent or conflicting results have been found in clinical trials when other promising compounds in vitro or in animal studies, such as policosanol, curcumin or silymarin, were used. Low oral bioavailability of substances, ineffective dosages, inadequate treatment duration and insufficient statistical approach may explain the lack of effectiveness observed in some human studies. Further clinical studies are needed to better understand the role of bioactive compounds in the prevention and management of MetS.Keywords: metabolic syndrome, bioactive substances, nutrition, cardiovascular riskFrancini-Pesenti FSpinella PCalò LADove Medical PressarticleMetabolic Syndromebioactive substancesnutritioncardiovascular riskSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1987-2002 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metabolic Syndrome bioactive substances nutrition cardiovascular risk Specialties of internal medicine RC581-951
spellingShingle	Metabolic Syndrome bioactive substances nutrition cardiovascular risk Specialties of internal medicine RC581-951 Francini-Pesenti F Spinella P Calò LA Potential role of phytochemicals in metabolic syndrome prevention and therapy
description	Francesco Francini-Pesenti,1 Paolo Spinella,1 Lorenzo A Calò2 1Department of Medicine (DIMED), Nutrition Unit, University of Padova-Azienda Ospedaliera, Padova, Italy; 2Department of Medicine (DIMED), Nephrology, Dialysis and Transplantation Unit, University of Padova-Azienda Ospedaliera, Padova, ItalyCorrespondence: Lorenzo A Cal&#x00F2Department of Medicine, Nephrology, Dialysis and Transplantation Unit, University of Padova-Azienda Ospedaliera, Via Giustiniani 2, Padova 35128, ItalyTel +39 049 821 3071Fax +39 049 821 7921Email renzcalo@unipd.itAbstract: Metabolic syndrome (MetS) is a set of cardiovascular risk factors which severely increases the risk of type II diabetes, renal disease and cardiovascular disease. Over the last decades, the role of dietary bioactive substances in features of MetS has been extensively investigated. Due to their multiple properties, these plant-derived natural compounds have demonstrated to provide positive effects in obesity, diabetes, renal and in cardiovascular disease. Catechins of green tea and caffeine reduce body mass index and waist circumference. Catechins, anthocyanins and proanthocyanidins of cocoa reduce blood pressure and blood glucose. Curcumin and silymarin exert hepatoprotective effects. Monacolins of red yeast rice are effective cholesterol-lowering agents. However, inconsistent or conflicting results have been found in clinical trials when other promising compounds in vitro or in animal studies, such as policosanol, curcumin or silymarin, were used. Low oral bioavailability of substances, ineffective dosages, inadequate treatment duration and insufficient statistical approach may explain the lack of effectiveness observed in some human studies. Further clinical studies are needed to better understand the role of bioactive compounds in the prevention and management of MetS.Keywords: metabolic syndrome, bioactive substances, nutrition, cardiovascular risk
format	article
author	Francini-Pesenti F Spinella P Calò LA
author_facet	Francini-Pesenti F Spinella P Calò LA
author_sort	Francini-Pesenti F
title	Potential role of phytochemicals in metabolic syndrome prevention and therapy
title_short	Potential role of phytochemicals in metabolic syndrome prevention and therapy
title_full	Potential role of phytochemicals in metabolic syndrome prevention and therapy
title_fullStr	Potential role of phytochemicals in metabolic syndrome prevention and therapy
title_full_unstemmed	Potential role of phytochemicals in metabolic syndrome prevention and therapy
title_sort	potential role of phytochemicals in metabolic syndrome prevention and therapy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/367d6fff8d23466a84ebe831d3f37b8e
work_keys_str_mv	AT francinipesentif potentialroleofphytochemicalsinmetabolicsyndromepreventionandtherapy AT spinellap potentialroleofphytochemicalsinmetabolicsyndromepreventionandtherapy AT calola potentialroleofphytochemicalsinmetabolicsyndromepreventionandtherapy
_version_	1718400288614776832

Potential role of phytochemicals in metabolic syndrome prevention and therapy

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