5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

5-Fluorouracil (5-FU) is a commonly used chemo drug to treat cancer patients. Using in vitro 5-FU treated organoids and in vivo 5-FU treated human cancer data, the authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 frequently observed in untreated cancers

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Bibliographic Details
Main Authors: Sharon Christensen, Bastiaan Van der Roest, Nicolle Besselink, Roel Janssen, Sander Boymans, John W. M. Martens, Marie-Laure Yaspo, Peter Priestley, Ewart Kuijk, Edwin Cuppen, Arne Van Hoeck
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/367df1c239a3400ab814acaa85f4ccbc
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Summary:5-Fluorouracil (5-FU) is a commonly used chemo drug to treat cancer patients. Using in vitro 5-FU treated organoids and in vivo 5-FU treated human cancer data, the authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 frequently observed in untreated cancers

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