5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

5-Fluorouracil (5-FU) is a commonly used chemo drug to treat cancer patients. Using in vitro 5-FU treated organoids and in vivo 5-FU treated human cancer data, the authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 frequently observed in untreated cancers

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Autores principales:	Sharon Christensen, Bastiaan Van der Roest, Nicolle Besselink, Roel Janssen, Sander Boymans, John W. M. Martens, Marie-Laure Yaspo, Peter Priestley, Ewart Kuijk, Edwin Cuppen, Arne Van Hoeck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/367df1c239a3400ab814acaa85f4ccbc
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spelling	oai:doaj.org-article:367df1c239a3400ab814acaa85f4ccbc2021-12-02T15:35:57Z5-Fluorouracil treatment induces characteristic T>G mutations in human cancer10.1038/s41467-019-12594-82041-1723https://doaj.org/article/367df1c239a3400ab814acaa85f4ccbc2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12594-8https://doaj.org/toc/2041-17235-Fluorouracil (5-FU) is a commonly used chemo drug to treat cancer patients. Using in vitro 5-FU treated organoids and in vivo 5-FU treated human cancer data, the authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 frequently observed in untreated cancersSharon ChristensenBastiaan Van der RoestNicolle BesselinkRoel JanssenSander BoymansJohn W. M. MartensMarie-Laure YaspoPeter PriestleyEwart KuijkEdwin CuppenArne Van HoeckNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sharon Christensen Bastiaan Van der Roest Nicolle Besselink Roel Janssen Sander Boymans John W. M. Martens Marie-Laure Yaspo Peter Priestley Ewart Kuijk Edwin Cuppen Arne Van Hoeck 5-Fluorouracil treatment induces characteristic T>G mutations in human cancer
description	5-Fluorouracil (5-FU) is a commonly used chemo drug to treat cancer patients. Using in vitro 5-FU treated organoids and in vivo 5-FU treated human cancer data, the authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 frequently observed in untreated cancers
format	article
author	Sharon Christensen Bastiaan Van der Roest Nicolle Besselink Roel Janssen Sander Boymans John W. M. Martens Marie-Laure Yaspo Peter Priestley Ewart Kuijk Edwin Cuppen Arne Van Hoeck
author_facet	Sharon Christensen Bastiaan Van der Roest Nicolle Besselink Roel Janssen Sander Boymans John W. M. Martens Marie-Laure Yaspo Peter Priestley Ewart Kuijk Edwin Cuppen Arne Van Hoeck
author_sort	Sharon Christensen
title	5-Fluorouracil treatment induces characteristic T>G mutations in human cancer
title_short	5-Fluorouracil treatment induces characteristic T>G mutations in human cancer
title_full	5-Fluorouracil treatment induces characteristic T>G mutations in human cancer
title_fullStr	5-Fluorouracil treatment induces characteristic T>G mutations in human cancer
title_full_unstemmed	5-Fluorouracil treatment induces characteristic T>G mutations in human cancer
title_sort	5-fluorouracil treatment induces characteristic t>g mutations in human cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/367df1c239a3400ab814acaa85f4ccbc
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5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

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