Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

PB1-mediated oligomerization of p62/SQSTM1 is essential for its function as a selective autophagy receptor. Here the authors present the cryo-EM structures of human and Arabidopsis PB1 domain helical assemblies and find that a conserved double arginine finger in the PB1 domain is important for p62 p...

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Autores principales:	Arjen J. Jakobi, Stefan T. Huber, Simon A. Mortensen, Sebastian W. Schultz, Anthimi Palara, Tanja Kuhm, Birendra Kumar Shrestha, Trond Lamark, Wim J. H. Hagen, Matthias Wilmanns, Terje Johansen, Andreas Brech, Carsten Sachse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3681d17d79a54c59a34880abff981baa
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spelling	oai:doaj.org-article:3681d17d79a54c59a34880abff981baa2021-12-02T15:33:31ZStructural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake10.1038/s41467-020-14343-82041-1723https://doaj.org/article/3681d17d79a54c59a34880abff981baa2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14343-8https://doaj.org/toc/2041-1723PB1-mediated oligomerization of p62/SQSTM1 is essential for its function as a selective autophagy receptor. Here the authors present the cryo-EM structures of human and Arabidopsis PB1 domain helical assemblies and find that a conserved double arginine finger in the PB1 domain is important for p62 polymerisation and lysosomal targeting of p62.Arjen J. JakobiStefan T. HuberSimon A. MortensenSebastian W. SchultzAnthimi PalaraTanja KuhmBirendra Kumar ShresthaTrond LamarkWim J. H. HagenMatthias WilmannsTerje JohansenAndreas BrechCarsten SachseNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arjen J. Jakobi Stefan T. Huber Simon A. Mortensen Sebastian W. Schultz Anthimi Palara Tanja Kuhm Birendra Kumar Shrestha Trond Lamark Wim J. H. Hagen Matthias Wilmanns Terje Johansen Andreas Brech Carsten Sachse Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
description	PB1-mediated oligomerization of p62/SQSTM1 is essential for its function as a selective autophagy receptor. Here the authors present the cryo-EM structures of human and Arabidopsis PB1 domain helical assemblies and find that a conserved double arginine finger in the PB1 domain is important for p62 polymerisation and lysosomal targeting of p62.
format	article
author	Arjen J. Jakobi Stefan T. Huber Simon A. Mortensen Sebastian W. Schultz Anthimi Palara Tanja Kuhm Birendra Kumar Shrestha Trond Lamark Wim J. H. Hagen Matthias Wilmanns Terje Johansen Andreas Brech Carsten Sachse
author_facet	Arjen J. Jakobi Stefan T. Huber Simon A. Mortensen Sebastian W. Schultz Anthimi Palara Tanja Kuhm Birendra Kumar Shrestha Trond Lamark Wim J. H. Hagen Matthias Wilmanns Terje Johansen Andreas Brech Carsten Sachse
author_sort	Arjen J. Jakobi
title	Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
title_short	Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
title_full	Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
title_fullStr	Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
title_full_unstemmed	Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
title_sort	structural basis of p62/sqstm1 helical filaments and their role in cellular cargo uptake
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3681d17d79a54c59a34880abff981baa
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Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

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