Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

Dietary protein dilution, where protein is reduced and replaced by other nutrient sources without caloric restriction, promotes metabolic health via the hepatokine Fgf21. Here, the authors show that essential amino acids threonine and tryptophan are necessary and sufficient to induce these effects.

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Autores principales:	Yann W. Yap, Patricia M. Rusu, Andrea Y. Chan, Barbara C. Fam, Andreas Jungmann, Samantha M. Solon-Biet, Christopher K. Barlow, Darren J. Creek, Cheng Huang, Ralf B. Schittenhelm, Bruce Morgan, Dieter Schmoll, Bente Kiens, Matthew D. W. Piper, Mathias Heikenwälder, Stephen J. Simpson, Stefan Bröer, Sofianos Andrikopoulos, Oliver J. Müller, Adam J. Rose
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36856bb21e41464a998b62244a235694
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spelling	oai:doaj.org-article:36856bb21e41464a998b62244a2356942021-12-02T17:30:52ZRestriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution10.1038/s41467-020-16568-z2041-1723https://doaj.org/article/36856bb21e41464a998b62244a2356942020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16568-zhttps://doaj.org/toc/2041-1723Dietary protein dilution, where protein is reduced and replaced by other nutrient sources without caloric restriction, promotes metabolic health via the hepatokine Fgf21. Here, the authors show that essential amino acids threonine and tryptophan are necessary and sufficient to induce these effects.Yann W. YapPatricia M. RusuAndrea Y. ChanBarbara C. FamAndreas JungmannSamantha M. Solon-BietChristopher K. BarlowDarren J. CreekCheng HuangRalf B. SchittenhelmBruce MorganDieter SchmollBente KiensMatthew D. W. PiperMathias HeikenwälderStephen J. SimpsonStefan BröerSofianos AndrikopoulosOliver J. MüllerAdam J. RoseNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yann W. Yap Patricia M. Rusu Andrea Y. Chan Barbara C. Fam Andreas Jungmann Samantha M. Solon-Biet Christopher K. Barlow Darren J. Creek Cheng Huang Ralf B. Schittenhelm Bruce Morgan Dieter Schmoll Bente Kiens Matthew D. W. Piper Mathias Heikenwälder Stephen J. Simpson Stefan Bröer Sofianos Andrikopoulos Oliver J. Müller Adam J. Rose Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
description	Dietary protein dilution, where protein is reduced and replaced by other nutrient sources without caloric restriction, promotes metabolic health via the hepatokine Fgf21. Here, the authors show that essential amino acids threonine and tryptophan are necessary and sufficient to induce these effects.
format	article
author	Yann W. Yap Patricia M. Rusu Andrea Y. Chan Barbara C. Fam Andreas Jungmann Samantha M. Solon-Biet Christopher K. Barlow Darren J. Creek Cheng Huang Ralf B. Schittenhelm Bruce Morgan Dieter Schmoll Bente Kiens Matthew D. W. Piper Mathias Heikenwälder Stephen J. Simpson Stefan Bröer Sofianos Andrikopoulos Oliver J. Müller Adam J. Rose
author_facet	Yann W. Yap Patricia M. Rusu Andrea Y. Chan Barbara C. Fam Andreas Jungmann Samantha M. Solon-Biet Christopher K. Barlow Darren J. Creek Cheng Huang Ralf B. Schittenhelm Bruce Morgan Dieter Schmoll Bente Kiens Matthew D. W. Piper Mathias Heikenwälder Stephen J. Simpson Stefan Bröer Sofianos Andrikopoulos Oliver J. Müller Adam J. Rose
author_sort	Yann W. Yap
title	Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
title_short	Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
title_full	Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
title_fullStr	Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
title_full_unstemmed	Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
title_sort	restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/36856bb21e41464a998b62244a235694
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Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

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