The Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis

Background: Timely and accurate diagnosis of tuberculosis (TB) remains a major challenge. Lipoarabinomannan (LAM) is a specific component of the cell envelope of Mycobacterium tuberculosis and is also a potential biomarker for the diagnosis of TB. Recently, the Fujifilm SILVAMP TB LAM test (FujiLAM)...

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Autores principales:	Zhenzhen Li, Xiang Tong, Sitong Liu, Jirong Yue, Hong Fan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tuberculosis FujiLAM sensitivity specificity meta-analysis Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/36867a4b7d5f4f7baf8f56a9ea007d47
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spelling	oai:doaj.org-article:36867a4b7d5f4f7baf8f56a9ea007d472021-11-30T23:57:49ZThe Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis2296-256510.3389/fpubh.2021.757133https://doaj.org/article/36867a4b7d5f4f7baf8f56a9ea007d472021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.757133/fullhttps://doaj.org/toc/2296-2565Background: Timely and accurate diagnosis of tuberculosis (TB) remains a major challenge. Lipoarabinomannan (LAM) is a specific component of the cell envelope of Mycobacterium tuberculosis and is also a potential biomarker for the diagnosis of TB. Recently, the Fujifilm SILVAMP TB LAM test (FujiLAM), as a novel urine lateral flow LAM test, was developed for the diagnosis of TB and is convenient and timely. Because of a difference in the diagnostic value of FujiLAM in the original studies, we conducted a meta-analysis to comprehensively assess the diagnostic value of FujiLAM in TB.Data Sources: We performed a literature search using the PubMed and EMBASE databases and commercial Internet search engines to identify studies.Methods: Searches of databases using relevant terms (“tuberculosis” or “TB”) and (“Fujifilm SILVAMP TB LAM” or “FujiLAM”) were performed. Screening, study reviewing, data extracting and assessing data quality was performed independently by two reviewers. We calculated the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio. To minimize potential heterogeneity, we performed subgroup analyses.Results: Nine articles were included in the meta-analysis. When using the microbiological reference standard (MRS), the results showed that the sensitivity and specificity of FujiLAM were 0.70 and 0.93, respectively, in adults with TB, while the sensitivity and specificity of FujiLAM in children with TB were 0.51 and 0.87. When using a comprehensive reference standard (CRS), the sensitivity and specificity of FujiLAM in adults with TB were 0.59 and 0.96, respectively, while the results showed that the sensitivity and specificity of FujiLAM in children with TB were 0.27 and 0.86, respectively. Subgroup analysis showed that FujiLAM had higher diagnostic sensitivity in patients with human immunodeficiency virus infection or CD4 cell counts < 200 cells/μL, both in adults and children.Conclusions: This meta-analysis suggests that FujiLAM has a high value in the diagnosis of adults with TB.Zhenzhen LiXiang TongSitong LiuJirong YueHong FanFrontiers Media S.A.articletuberculosisFujiLAMsensitivityspecificitymeta-analysisPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tuberculosis FujiLAM sensitivity specificity meta-analysis Public aspects of medicine RA1-1270
spellingShingle	tuberculosis FujiLAM sensitivity specificity meta-analysis Public aspects of medicine RA1-1270 Zhenzhen Li Xiang Tong Sitong Liu Jirong Yue Hong Fan The Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis
description	Background: Timely and accurate diagnosis of tuberculosis (TB) remains a major challenge. Lipoarabinomannan (LAM) is a specific component of the cell envelope of Mycobacterium tuberculosis and is also a potential biomarker for the diagnosis of TB. Recently, the Fujifilm SILVAMP TB LAM test (FujiLAM), as a novel urine lateral flow LAM test, was developed for the diagnosis of TB and is convenient and timely. Because of a difference in the diagnostic value of FujiLAM in the original studies, we conducted a meta-analysis to comprehensively assess the diagnostic value of FujiLAM in TB.Data Sources: We performed a literature search using the PubMed and EMBASE databases and commercial Internet search engines to identify studies.Methods: Searches of databases using relevant terms (“tuberculosis” or “TB”) and (“Fujifilm SILVAMP TB LAM” or “FujiLAM”) were performed. Screening, study reviewing, data extracting and assessing data quality was performed independently by two reviewers. We calculated the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio. To minimize potential heterogeneity, we performed subgroup analyses.Results: Nine articles were included in the meta-analysis. When using the microbiological reference standard (MRS), the results showed that the sensitivity and specificity of FujiLAM were 0.70 and 0.93, respectively, in adults with TB, while the sensitivity and specificity of FujiLAM in children with TB were 0.51 and 0.87. When using a comprehensive reference standard (CRS), the sensitivity and specificity of FujiLAM in adults with TB were 0.59 and 0.96, respectively, while the results showed that the sensitivity and specificity of FujiLAM in children with TB were 0.27 and 0.86, respectively. Subgroup analysis showed that FujiLAM had higher diagnostic sensitivity in patients with human immunodeficiency virus infection or CD4 cell counts < 200 cells/μL, both in adults and children.Conclusions: This meta-analysis suggests that FujiLAM has a high value in the diagnosis of adults with TB.
format	article
author	Zhenzhen Li Xiang Tong Sitong Liu Jirong Yue Hong Fan
author_facet	Zhenzhen Li Xiang Tong Sitong Liu Jirong Yue Hong Fan
author_sort	Zhenzhen Li
title	The Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis
title_short	The Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis
title_full	The Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis
title_fullStr	The Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis
title_full_unstemmed	The Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis
title_sort	value of fujilam in the diagnosis of tuberculosis: a systematic review and meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/36867a4b7d5f4f7baf8f56a9ea007d47
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The Value of FujiLAM in the Diagnosis of Tuberculosis: A Systematic Review and Meta-Analysis

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