Dynamics of spatiotemporal line defects and chaos control in complex excitable systems

Abstract Spatiotemporal pattern formation governs dynamics and functions in various biological systems. In the heart, excitable waves can form complex oscillatory and chaotic patterns even at an abnormally higher frequency than normal heart beats, which increase the risk of fatal heart conditions by...

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Autores principales:	Marcel Hörning, François Blanchard, Akihiro Isomura, Kenichi Yoshikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/368e71808d7046ba94a6a31e57f8f9a3
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spelling	oai:doaj.org-article:368e71808d7046ba94a6a31e57f8f9a32021-12-02T11:52:39ZDynamics of spatiotemporal line defects and chaos control in complex excitable systems10.1038/s41598-017-08011-z2045-2322https://doaj.org/article/368e71808d7046ba94a6a31e57f8f9a32017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08011-zhttps://doaj.org/toc/2045-2322Abstract Spatiotemporal pattern formation governs dynamics and functions in various biological systems. In the heart, excitable waves can form complex oscillatory and chaotic patterns even at an abnormally higher frequency than normal heart beats, which increase the risk of fatal heart conditions by inhibiting normal blood circulation. Previous studies suggested that line defects (nodal lines) play a critical role in stabilizing those undesirable patterns. However, it remains unknown if the line defects are static or dynamically changing structures in heart tissue. Through in vitro experiments of heart tissue observation, we reveal the spatiotemporal dynamics of line defects in rotating spiral waves. We combined a novel signaling over-sampling technique with a multi-dimensional Fourier analysis, showing that line defects can translate, merge, collapse and form stable singularities with even and odd parity while maintaining a stable oscillation of the spiral wave in the tissue. These findings provide insights into a broad class of complex periodic systems, with particular impact to the control and understanding of heart diseases.Marcel HörningFrançois BlanchardAkihiro IsomuraKenichi YoshikawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcel Hörning François Blanchard Akihiro Isomura Kenichi Yoshikawa Dynamics of spatiotemporal line defects and chaos control in complex excitable systems
description	Abstract Spatiotemporal pattern formation governs dynamics and functions in various biological systems. In the heart, excitable waves can form complex oscillatory and chaotic patterns even at an abnormally higher frequency than normal heart beats, which increase the risk of fatal heart conditions by inhibiting normal blood circulation. Previous studies suggested that line defects (nodal lines) play a critical role in stabilizing those undesirable patterns. However, it remains unknown if the line defects are static or dynamically changing structures in heart tissue. Through in vitro experiments of heart tissue observation, we reveal the spatiotemporal dynamics of line defects in rotating spiral waves. We combined a novel signaling over-sampling technique with a multi-dimensional Fourier analysis, showing that line defects can translate, merge, collapse and form stable singularities with even and odd parity while maintaining a stable oscillation of the spiral wave in the tissue. These findings provide insights into a broad class of complex periodic systems, with particular impact to the control and understanding of heart diseases.
format	article
author	Marcel Hörning François Blanchard Akihiro Isomura Kenichi Yoshikawa
author_facet	Marcel Hörning François Blanchard Akihiro Isomura Kenichi Yoshikawa
author_sort	Marcel Hörning
title	Dynamics of spatiotemporal line defects and chaos control in complex excitable systems
title_short	Dynamics of spatiotemporal line defects and chaos control in complex excitable systems
title_full	Dynamics of spatiotemporal line defects and chaos control in complex excitable systems
title_fullStr	Dynamics of spatiotemporal line defects and chaos control in complex excitable systems
title_full_unstemmed	Dynamics of spatiotemporal line defects and chaos control in complex excitable systems
title_sort	dynamics of spatiotemporal line defects and chaos control in complex excitable systems
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/368e71808d7046ba94a6a31e57f8f9a3
work_keys_str_mv	AT marcelhorning dynamicsofspatiotemporallinedefectsandchaoscontrolincomplexexcitablesystems AT francoisblanchard dynamicsofspatiotemporallinedefectsandchaoscontrolincomplexexcitablesystems AT akihiroisomura dynamicsofspatiotemporallinedefectsandchaoscontrolincomplexexcitablesystems AT kenichiyoshikawa dynamicsofspatiotemporallinedefectsandchaoscontrolincomplexexcitablesystems
_version_	1718394977112817664

Dynamics of spatiotemporal line defects and chaos control in complex excitable systems

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