ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex

2-oxoglutarate links mitochondrial metabolism to oxygen sensing, gene transcription and epigenetic modifications. Here, the authors describe a mutagenesis screen to find genes that control 2-oxoglutarate levels, and identify ABHD11 as a mitochondrial regulator of 2-oxoglutarate abundance.

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Autores principales:	Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza, James A. Nathan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/368ff8225df849cf9afb4ff9c4c9c5e7
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spelling	oai:doaj.org-article:368ff8225df849cf9afb4ff9c4c9c5e72021-12-02T16:28:07ZABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex10.1038/s41467-020-17862-62041-1723https://doaj.org/article/368ff8225df849cf9afb4ff9c4c9c5e72020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17862-6https://doaj.org/toc/2041-17232-oxoglutarate links mitochondrial metabolism to oxygen sensing, gene transcription and epigenetic modifications. Here, the authors describe a mutagenesis screen to find genes that control 2-oxoglutarate levels, and identify ABHD11 as a mitochondrial regulator of 2-oxoglutarate abundance.Peter S. J. BaileyBrian M. OrtmannAnthony W. MartinelliJack W. HoughtonAna S. H. CostaStephen P. BurrRobin AntrobusChristian FrezzaJames A. NathanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter S. J. Bailey Brian M. Ortmann Anthony W. Martinelli Jack W. Houghton Ana S. H. Costa Stephen P. Burr Robin Antrobus Christian Frezza James A. Nathan ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
description	2-oxoglutarate links mitochondrial metabolism to oxygen sensing, gene transcription and epigenetic modifications. Here, the authors describe a mutagenesis screen to find genes that control 2-oxoglutarate levels, and identify ABHD11 as a mitochondrial regulator of 2-oxoglutarate abundance.
format	article
author	Peter S. J. Bailey Brian M. Ortmann Anthony W. Martinelli Jack W. Houghton Ana S. H. Costa Stephen P. Burr Robin Antrobus Christian Frezza James A. Nathan
author_facet	Peter S. J. Bailey Brian M. Ortmann Anthony W. Martinelli Jack W. Houghton Ana S. H. Costa Stephen P. Burr Robin Antrobus Christian Frezza James A. Nathan
author_sort	Peter S. J. Bailey
title	ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
title_short	ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
title_full	ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
title_fullStr	ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
title_full_unstemmed	ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
title_sort	abhd11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/368ff8225df849cf9afb4ff9c4c9c5e7
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ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex

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