Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma

The primary aim of this study was to examine the correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognostic significance in nasopharyngeal carcinoma (NPC). The study tissues were collected from 285 patients with NPC and normal mucosal tissues were obtained fr...

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Autores principales:	Yan Wang, Jie Sun, Ninghua Yao
Formato:	article
Lenguaje:	EN
Publicado:	PAGEPress Publications 2021
Materias:	AKT mTOR P70S6 nasopharyngeal carcinoma prognosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3692a3acfc854eb8a41cda5444dbd4fc
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spelling	oai:doaj.org-article:3692a3acfc854eb8a41cda5444dbd4fc2021-11-17T07:41:24ZCorrelation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma10.4081/ejh.2021.33041121-760X2038-8306https://doaj.org/article/3692a3acfc854eb8a41cda5444dbd4fc2021-11-01T00:00:00Zhttps://ejh.it/index.php/ejh/article/view/3304https://doaj.org/toc/1121-760Xhttps://doaj.org/toc/2038-8306 The primary aim of this study was to examine the correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognostic significance in nasopharyngeal carcinoma (NPC). The study tissues were collected from 285 patients with NPC and normal mucosal tissues were obtained from 289 individuals with normal nasopharynxes. Immunohistochemical staining was used to detected the expression of the AKT, mTOR, and p70 ribosomal S6 kinase (P70S6K) proteins. Follow-up was performed for between 8 and 60 months. Spearman’s rank correlation analysis was performed to evaluate the correlation of the expression of the AKT, mTOR, and P70S6K proteins in NPC tissues. Kaplan-Meier curves were plotted to show the survival of patients with NPC. A Cox proportional hazards model was used to explore the independent risk factors for prognosis. The expression of the AKT, mTOR, and P70S6K proteins in NPC tissues was higher than that in healthy nasopharyngeal mucosal tissues, and was correlated with T-staging, N-staging, clinical stage, distant metastasis, and differentiation. The positive expression of the AKT, mTOR, and P70S6K proteins was higher in patients with stage III/IV NPC, low differentiation, and metastasis. The survival rates of patients with NPC with AKT-positive, mTOR-positive, and P70S6K-positive expression were considerably lower than those without the expression of these proteins. Distant metastasis and the overexpression of the AKT, mTOR, and P70S6 proteins were independent risk factors for the prognosis of patients with NPC. The results obtained from this study indicated an association between the AKT/mTOR signaling pathway and the progression of NPC. The upregulation of the AKT/mTOR pathway in patients with NPC is a predictor of poor prognosis. Yan WangJie SunNinghua YaoPAGEPress PublicationsarticleAKTmTORP70S6nasopharyngeal carcinomaprognosisBiology (General)QH301-705.5ENEuropean Journal of Histochemistry , Vol 65, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AKT mTOR P70S6 nasopharyngeal carcinoma prognosis Biology (General) QH301-705.5
spellingShingle	AKT mTOR P70S6 nasopharyngeal carcinoma prognosis Biology (General) QH301-705.5 Yan Wang Jie Sun Ninghua Yao Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma
description	The primary aim of this study was to examine the correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognostic significance in nasopharyngeal carcinoma (NPC). The study tissues were collected from 285 patients with NPC and normal mucosal tissues were obtained from 289 individuals with normal nasopharynxes. Immunohistochemical staining was used to detected the expression of the AKT, mTOR, and p70 ribosomal S6 kinase (P70S6K) proteins. Follow-up was performed for between 8 and 60 months. Spearman’s rank correlation analysis was performed to evaluate the correlation of the expression of the AKT, mTOR, and P70S6K proteins in NPC tissues. Kaplan-Meier curves were plotted to show the survival of patients with NPC. A Cox proportional hazards model was used to explore the independent risk factors for prognosis. The expression of the AKT, mTOR, and P70S6K proteins in NPC tissues was higher than that in healthy nasopharyngeal mucosal tissues, and was correlated with T-staging, N-staging, clinical stage, distant metastasis, and differentiation. The positive expression of the AKT, mTOR, and P70S6K proteins was higher in patients with stage III/IV NPC, low differentiation, and metastasis. The survival rates of patients with NPC with AKT-positive, mTOR-positive, and P70S6K-positive expression were considerably lower than those without the expression of these proteins. Distant metastasis and the overexpression of the AKT, mTOR, and P70S6 proteins were independent risk factors for the prognosis of patients with NPC. The results obtained from this study indicated an association between the AKT/mTOR signaling pathway and the progression of NPC. The upregulation of the AKT/mTOR pathway in patients with NPC is a predictor of poor prognosis.
format	article
author	Yan Wang Jie Sun Ninghua Yao
author_facet	Yan Wang Jie Sun Ninghua Yao
author_sort	Yan Wang
title	Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma
title_short	Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma
title_full	Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma
title_fullStr	Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma
title_full_unstemmed	Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma
title_sort	correlation of the akt/mtor signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma
publisher	PAGEPress Publications
publishDate	2021
url	https://doaj.org/article/3692a3acfc854eb8a41cda5444dbd4fc
work_keys_str_mv	AT yanwang correlationoftheaktmtorsignalingpathwaywiththeclinicopathologicalfeaturesandprognosisofnasopharyngealcarcinoma AT jiesun correlationoftheaktmtorsignalingpathwaywiththeclinicopathologicalfeaturesandprognosisofnasopharyngealcarcinoma AT ninghuayao correlationoftheaktmtorsignalingpathwaywiththeclinicopathologicalfeaturesandprognosisofnasopharyngealcarcinoma
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Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma

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