Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

Abstract Background Parental body mass index (BMI) is associated with pregnancy outcomes. But the effect of parental prepregnancy BMI on offspring conceived via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), especially the birth defect, remains to be determined. This study...

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Autores principales:	Ruixue Chen, Lifen Chen, Yifeng Liu, Feixia Wang, Siwen Wang, Yun Huang, Kai-Lun Hu, Yuzhi Fan, Ruoyan Liu, Runjv Zhang, Dan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Body mass index Obesity Assisted reproductive technology Neonatal outcome Birth defect Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/3696bf5a7857417a94930b186daab5cc
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spelling	oai:doaj.org-article:3696bf5a7857417a94930b186daab5cc2021-11-28T12:29:51ZAssociation of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study10.1186/s12884-021-04261-y1471-2393https://doaj.org/article/3696bf5a7857417a94930b186daab5cc2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12884-021-04261-yhttps://doaj.org/toc/1471-2393Abstract Background Parental body mass index (BMI) is associated with pregnancy outcomes. But the effect of parental prepregnancy BMI on offspring conceived via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), especially the birth defect, remains to be determined. This study aimed to investigate the associations of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles. Methods We conducted a retrospective cohort study including 5741 couples in their first fresh IVF/ICSI cycles admitted to Women’s Hospital, School of Medicine, Zhejiang University from January 2013 to July 2016. The primary outcome was birth defects, which was classified according to the International Classification of Diseases, 10th Revision. Secondary outcomes included preterm delivery rate, infant gender, birth weight, small-for-gestational age (SGA) and large-for-gestational age (LGA). Multilevel regression analyses were used to assess the associations of parental prepregnancy BMI with neonatal outcomes and birth defect. Results In singletons, couples with prepregnancy BMI ≥25 kg/m2 had higher odds of LGA than those with BMI < 25 kg/m2. The birth defect rate was significantly higher when paternal prepregnancy BMI ≥25 kg/m2 in IVF cycles (aOR 1.82, 95% CI 1.06–3.10) and maternal BMI ≥25 kg/m2 in ICSI cycles (aOR 4.89, 95% CI 1.45–16.53). For subcategories of birth defects, only the odds of congenital malformations of musculoskeletal system was significantly increased in IVF offspring with paternal BMI ≥25 kg/m2 (aOR 4.55, 95% CI 1.32–15.71). For twins, there was no significant difference among four groups, except for the lower birth weight of IVF female infants. Conclusions Parental prepregnancy BMI ≥25 kg/m2 is associated with higher incidence of LGA in IVF/ICSI singletons. Paternal prepregnancy BMI ≥25 kg/m2 was likely to have higher risk of birth defect in IVF offspring than those with BMI < 25 kg/m2, particularly in the musculoskeletal system. It is essential for overweight or obesity couples to lose weight before IVF/ICSI treatments.Ruixue ChenLifen ChenYifeng LiuFeixia WangSiwen WangYun HuangKai-Lun HuYuzhi FanRuoyan LiuRunjv ZhangDan ZhangBMCarticleBody mass indexObesityAssisted reproductive technologyNeonatal outcomeBirth defectGynecology and obstetricsRG1-991ENBMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Body mass index Obesity Assisted reproductive technology Neonatal outcome Birth defect Gynecology and obstetrics RG1-991
spellingShingle	Body mass index Obesity Assisted reproductive technology Neonatal outcome Birth defect Gynecology and obstetrics RG1-991 Ruixue Chen Lifen Chen Yifeng Liu Feixia Wang Siwen Wang Yun Huang Kai-Lun Hu Yuzhi Fan Ruoyan Liu Runjv Zhang Dan Zhang Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
description	Abstract Background Parental body mass index (BMI) is associated with pregnancy outcomes. But the effect of parental prepregnancy BMI on offspring conceived via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), especially the birth defect, remains to be determined. This study aimed to investigate the associations of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles. Methods We conducted a retrospective cohort study including 5741 couples in their first fresh IVF/ICSI cycles admitted to Women’s Hospital, School of Medicine, Zhejiang University from January 2013 to July 2016. The primary outcome was birth defects, which was classified according to the International Classification of Diseases, 10th Revision. Secondary outcomes included preterm delivery rate, infant gender, birth weight, small-for-gestational age (SGA) and large-for-gestational age (LGA). Multilevel regression analyses were used to assess the associations of parental prepregnancy BMI with neonatal outcomes and birth defect. Results In singletons, couples with prepregnancy BMI ≥25 kg/m2 had higher odds of LGA than those with BMI < 25 kg/m2. The birth defect rate was significantly higher when paternal prepregnancy BMI ≥25 kg/m2 in IVF cycles (aOR 1.82, 95% CI 1.06–3.10) and maternal BMI ≥25 kg/m2 in ICSI cycles (aOR 4.89, 95% CI 1.45–16.53). For subcategories of birth defects, only the odds of congenital malformations of musculoskeletal system was significantly increased in IVF offspring with paternal BMI ≥25 kg/m2 (aOR 4.55, 95% CI 1.32–15.71). For twins, there was no significant difference among four groups, except for the lower birth weight of IVF female infants. Conclusions Parental prepregnancy BMI ≥25 kg/m2 is associated with higher incidence of LGA in IVF/ICSI singletons. Paternal prepregnancy BMI ≥25 kg/m2 was likely to have higher risk of birth defect in IVF offspring than those with BMI < 25 kg/m2, particularly in the musculoskeletal system. It is essential for overweight or obesity couples to lose weight before IVF/ICSI treatments.
format	article
author	Ruixue Chen Lifen Chen Yifeng Liu Feixia Wang Siwen Wang Yun Huang Kai-Lun Hu Yuzhi Fan Ruoyan Liu Runjv Zhang Dan Zhang
author_facet	Ruixue Chen Lifen Chen Yifeng Liu Feixia Wang Siwen Wang Yun Huang Kai-Lun Hu Yuzhi Fan Ruoyan Liu Runjv Zhang Dan Zhang
author_sort	Ruixue Chen
title	Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_short	Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_full	Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_fullStr	Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_full_unstemmed	Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_sort	association of parental prepregnancy bmi with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/3696bf5a7857417a94930b186daab5cc
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Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

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