Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients

Roger A Goldberg,1,2 Sabri Raza,1 Eric Walford,1 William J Feuer,1 Jeffrey L Goldberg1,3 1Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA; 2Tufts-New England Eye Center/Ophthalmic Consultants of Boston, Boston, MA, USA; 3Shiley Eye Center, University of California San Diego, San D...

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Autores principales:	Goldberg RA, Raza S, Walford E, Feuer WJ, Goldberg JL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/36983bcd37f4432ba5cebd082930e586
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spelling	oai:doaj.org-article:36983bcd37f4432ba5cebd082930e5862021-12-02T07:07:52ZFuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients1177-5483https://doaj.org/article/36983bcd37f4432ba5cebd082930e5862014-09-01T00:00:00Zhttp://www.dovepress.com/fuchs-endothelial-corneal-dystrophy-clinical-characteristics-of-surgic-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Roger A Goldberg,1,2 Sabri Raza,1 Eric Walford,1 William J Feuer,1 Jeffrey L Goldberg1,3 1Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA; 2Tufts-New England Eye Center/Ophthalmic Consultants of Boston, Boston, MA, USA; 3Shiley Eye Center, University of California San Diego, San Diego, CA, USA Purpose: To review the patient and clinical characteristics of patients with Fuchs endothelial corneal dystrophy (FECD). Methods: Review of records for every patient who presented to the Bascom Palmer Eye Institute between 2003 and 2009 whose visit was coded for endothelial corneal dystrophy (International Classification of Diseases, Ninth Revision [ICD9] 371.57), bullous keratopathy (ICD9 371.23), or who underwent a corneal surgery with or without cataract extraction. Demographic, clinical, and ancillary testing data were collected from the time of presentation, diagnosis, and follow-up, and the use, timing, and type of surgical interventions was documented, with 6-month and final visual acuities recorded. Results: A total of 2,370 charts were included in this study, of which 966 patients had a diagnosis of FECD. Of these, 197 patients (21%) received a corneal transplantation procedure. The surgery most often performed was penetrating keratoplasty with or without cataract extraction (66%), followed by endothelial keratoplasty with or without cataract extraction (34%). The risk factors for surgery include worse visual acuity at presentation (20/60 Snellen visual acuity in surgical patients versus 20/40 Snellen visual acuity in nonsurgical patients, P<0.001), greater average central corneal thickness (635 µm versus 592 µm, P<0.001), loss of visual acuity over time (two lines lost versus zero lines lost, P<0.001), increasing age (P<0.001), and male sex (P=0.008). Over half of patients (52%) did not receive surgery despite poor vision. Conclusion: During this time period, FECD did not have a consistent pattern for management or treatment, and despite advances in surgical techniques, most patients were still managed without surgery. Keywords: Fuchs corneal dystrophy, bullous keratopathy, penetrating keratoplasty, endothelial keratoplastyGoldberg RARaza SWalford EFeuer WJGoldberg JLDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1761-1766 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Goldberg RA Raza S Walford E Feuer WJ Goldberg JL Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients
description	Roger A Goldberg,1,2 Sabri Raza,1 Eric Walford,1 William J Feuer,1 Jeffrey L Goldberg1,3 1Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA; 2Tufts-New England Eye Center/Ophthalmic Consultants of Boston, Boston, MA, USA; 3Shiley Eye Center, University of California San Diego, San Diego, CA, USA Purpose: To review the patient and clinical characteristics of patients with Fuchs endothelial corneal dystrophy (FECD). Methods: Review of records for every patient who presented to the Bascom Palmer Eye Institute between 2003 and 2009 whose visit was coded for endothelial corneal dystrophy (International Classification of Diseases, Ninth Revision [ICD9] 371.57), bullous keratopathy (ICD9 371.23), or who underwent a corneal surgery with or without cataract extraction. Demographic, clinical, and ancillary testing data were collected from the time of presentation, diagnosis, and follow-up, and the use, timing, and type of surgical interventions was documented, with 6-month and final visual acuities recorded. Results: A total of 2,370 charts were included in this study, of which 966 patients had a diagnosis of FECD. Of these, 197 patients (21%) received a corneal transplantation procedure. The surgery most often performed was penetrating keratoplasty with or without cataract extraction (66%), followed by endothelial keratoplasty with or without cataract extraction (34%). The risk factors for surgery include worse visual acuity at presentation (20/60 Snellen visual acuity in surgical patients versus 20/40 Snellen visual acuity in nonsurgical patients, P<0.001), greater average central corneal thickness (635 µm versus 592 µm, P<0.001), loss of visual acuity over time (two lines lost versus zero lines lost, P<0.001), increasing age (P<0.001), and male sex (P=0.008). Over half of patients (52%) did not receive surgery despite poor vision. Conclusion: During this time period, FECD did not have a consistent pattern for management or treatment, and despite advances in surgical techniques, most patients were still managed without surgery. Keywords: Fuchs corneal dystrophy, bullous keratopathy, penetrating keratoplasty, endothelial keratoplasty
format	article
author	Goldberg RA Raza S Walford E Feuer WJ Goldberg JL
author_facet	Goldberg RA Raza S Walford E Feuer WJ Goldberg JL
author_sort	Goldberg RA
title	Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients
title_short	Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients
title_full	Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients
title_fullStr	Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients
title_full_unstemmed	Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients
title_sort	fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/36983bcd37f4432ba5cebd082930e586
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Fuchs endothelial corneal dystrophy: clinical characteristics of surgical and nonsurgical patients

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