Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial
Abstract This study aimed to provide insights into the relationship between lipid levels and new-onset diabetes (NOD) in 14,864 Chinese hypertensive patients without diabetes (6056 men and 8808 women) aged 45–75 years from the China Stroke Primary Prevention Trial (CSPPT, led by Nanfang Hospital, Gu...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/3699b55f7c0e4c04a0a0aafc8c44f589 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:3699b55f7c0e4c04a0a0aafc8c44f589 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:3699b55f7c0e4c04a0a0aafc8c44f5892021-12-02T15:05:29ZLipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial10.1038/s41598-017-07355-w2045-2322https://doaj.org/article/3699b55f7c0e4c04a0a0aafc8c44f5892017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07355-whttps://doaj.org/toc/2045-2322Abstract This study aimed to provide insights into the relationship between lipid levels and new-onset diabetes (NOD) in 14,864 Chinese hypertensive patients without diabetes (6056 men and 8808 women) aged 45–75 years from the China Stroke Primary Prevention Trial (CSPPT, led by Nanfang Hospital, Guangzhou, China). NOD (defined as fasting plasma glucose (FPG) ≥ 7.0 mmol/L at the end of study or self-reported physician diagnosis of diabetes or self-reported use of hypoglycemic agents during follow-up) was analyzed using multivariate analysis. Follow-up was censored on August 24, 2014. Among the 14,864 subjects, 1615 developed NOD (10.9%, men = 10.8% and women = 10.9%). Increased triglycerides (TG) [odds ratio (OR) = 1.18; 95% confidence interval (CI): 1.13–1.25, P < 0.001], TG/HDL (OR = 1.12; 95%CI: 1.08–1.17, P < 0.001), and decreased high density lipoprotein (HDL) (OR = 0.79; 95%CI: 0.67–0.93, P = 0.005) were associated with NOD, independently from age, gender, body mass index, clinical center, systolic blood pressure, diastolic blood pressure, FPG, smoking, and drinking. Compared to subjects with the methylenetetrahydrofolate reductase (MTHFR) 677 CC and TT genotypes, those with the CT genotype had a higher risk of NOD (OR = 1.54; 95%CI: 1.30–1.81, P for interaction = 0.044) in subjects with high TG. These results suggested that TG and TG/HDL were independent risk factors for NOD in this Chinese hypertensive population. HDL was a protective factor for NOD.Leliang LiPing LiJuan YangXiao HuangHuihui BaoChunyan ZhangYun SongMin ZhaoMeng JiYi WangGeng QianGenfu TangShanqun JiangQiang DongYan ZhangJianping LiXiping XuBinyan WangYong HuoXiaoshu ChengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Leliang Li Ping Li Juan Yang Xiao Huang Huihui Bao Chunyan Zhang Yun Song Min Zhao Meng Ji Yi Wang Geng Qian Genfu Tang Shanqun Jiang Qiang Dong Yan Zhang Jianping Li Xiping Xu Binyan Wang Yong Huo Xiaoshu Cheng Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial |
| description |
Abstract This study aimed to provide insights into the relationship between lipid levels and new-onset diabetes (NOD) in 14,864 Chinese hypertensive patients without diabetes (6056 men and 8808 women) aged 45–75 years from the China Stroke Primary Prevention Trial (CSPPT, led by Nanfang Hospital, Guangzhou, China). NOD (defined as fasting plasma glucose (FPG) ≥ 7.0 mmol/L at the end of study or self-reported physician diagnosis of diabetes or self-reported use of hypoglycemic agents during follow-up) was analyzed using multivariate analysis. Follow-up was censored on August 24, 2014. Among the 14,864 subjects, 1615 developed NOD (10.9%, men = 10.8% and women = 10.9%). Increased triglycerides (TG) [odds ratio (OR) = 1.18; 95% confidence interval (CI): 1.13–1.25, P < 0.001], TG/HDL (OR = 1.12; 95%CI: 1.08–1.17, P < 0.001), and decreased high density lipoprotein (HDL) (OR = 0.79; 95%CI: 0.67–0.93, P = 0.005) were associated with NOD, independently from age, gender, body mass index, clinical center, systolic blood pressure, diastolic blood pressure, FPG, smoking, and drinking. Compared to subjects with the methylenetetrahydrofolate reductase (MTHFR) 677 CC and TT genotypes, those with the CT genotype had a higher risk of NOD (OR = 1.54; 95%CI: 1.30–1.81, P for interaction = 0.044) in subjects with high TG. These results suggested that TG and TG/HDL were independent risk factors for NOD in this Chinese hypertensive population. HDL was a protective factor for NOD. |
| format |
article |
| author |
Leliang Li Ping Li Juan Yang Xiao Huang Huihui Bao Chunyan Zhang Yun Song Min Zhao Meng Ji Yi Wang Geng Qian Genfu Tang Shanqun Jiang Qiang Dong Yan Zhang Jianping Li Xiping Xu Binyan Wang Yong Huo Xiaoshu Cheng |
| author_facet |
Leliang Li Ping Li Juan Yang Xiao Huang Huihui Bao Chunyan Zhang Yun Song Min Zhao Meng Ji Yi Wang Geng Qian Genfu Tang Shanqun Jiang Qiang Dong Yan Zhang Jianping Li Xiping Xu Binyan Wang Yong Huo Xiaoshu Cheng |
| author_sort |
Leliang Li |
| title |
Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial |
| title_short |
Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial |
| title_full |
Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial |
| title_fullStr |
Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial |
| title_full_unstemmed |
Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial |
| title_sort |
lipid levels and new-onset diabetes in a hypertensive population: the china stroke primary prevention trial |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/3699b55f7c0e4c04a0a0aafc8c44f589 |
| work_keys_str_mv |
AT leliangli lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT pingli lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT juanyang lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT xiaohuang lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT huihuibao lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT chunyanzhang lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT yunsong lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT minzhao lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT mengji lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT yiwang lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT gengqian lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT genfutang lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT shanqunjiang lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT qiangdong lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT yanzhang lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT jianpingli lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT xipingxu lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT binyanwang lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT yonghuo lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial AT xiaoshucheng lipidlevelsandnewonsetdiabetesinahypertensivepopulationthechinastrokeprimarypreventiontrial |
| _version_ |
1718388821679144960 |